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Aquaporins: important but elusive drug targets.
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Europe PubMed Central
PMC publication ID
4067137
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24625825%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 March 2020
review article
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Europe PubMed Central
title
Aquaporins: important but elusive drug targets
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
4067137
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24625825%20AND%20SRC:MED&resulttype=core&format=json
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10 March 2020
author
Marios Papadopoulos
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3
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Europe PubMed Central
PMC publication ID
4067137
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24625825%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 March 2020
Alan S Verkman
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object named as
Alan S Verkman
1 reference
stated in
Europe PubMed Central
PMC publication ID
4067137
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24625825%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 March 2020
author name string
Marc O Anderson
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2
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Europe PubMed Central
PMC publication ID
4067137
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24625825%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 March 2020
publication date
14 March 2014
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Europe PubMed Central
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4067137
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retrieved
10 March 2020
published in
Nature Reviews Drug Discovery
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stated in
Europe PubMed Central
PMC publication ID
4067137
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24625825%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 March 2020
volume
13
1 reference
stated in
Europe PubMed Central
PMC publication ID
4067137
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24625825%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 March 2020
issue
4
1 reference
stated in
Europe PubMed Central
PMC publication ID
4067137
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24625825%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 March 2020
page(s)
259-277
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Europe PubMed Central
PMC publication ID
4067137
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24625825%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 March 2020
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In silico study of Aquaporin V: Effects and affinity of the central pore-occluding lipid
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Early responses to adenoviral-mediated transfer of the aquaporin-1 cDNA for radiation-induced salivary hypofunction
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Enzymatic deglycosylation converts pathogenic neuromyelitis optica anti-aquaporin-4 immunoglobulin G into therapeutic antibody.
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Neuromyelitis optica IgG does not alter aquaporin-4 water permeability, plasma membrane M1/M23 isoform content, or supramolecular assembly
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Noble metal-dithiocarbamates precious allies in the fight against cancer.
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Chemokine-dependent T cell migration requires aquaporin-3-mediated hydrogen peroxide uptake
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Aquaporin 2-increased renal cell proliferation is associated with cell volume regulation.
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Targeting aquaporin function: potent inhibition of aquaglyceroporin-3 by a gold-based compound
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Congenital nephrogenic diabetes insipidus: the current state of affairs
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Complement-dependent cytotoxicity in neuromyelitis optica requires aquaporin-4 protein assembly in orthogonal arrays
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Small-molecule inhibitors of NMO-IgG binding to aquaporin-4 reduce astrocyte cytotoxicity in neuromyelitis optica.
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Anti-aquaporin-4 monoclonal antibody blocker therapy for neuromyelitis optica.
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4 July 2018
Light inactivation of water transport and protein-protein interactions of aquaporin-Killer Red chimeras
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Aquaporin-5: a marker protein for proliferation and migration of human breast cancer cells
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Aquaporin-9 protein is the primary route of hepatocyte glycerol uptake for glycerol gluconeogenesis in mice
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Hyperosmotic stress induces aquaporin-dependent cell shrinkage, polyphosphate synthesis, amino acid accumulation, and global gene expression changes in Trypanosoma cruzi.
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4 July 2018
Glial-conditional deletion of aquaporin-4 (Aqp4) reduces blood-brain water uptake and confers barrier function on perivascular astrocyte endfeet
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4 July 2018
Vasopressin-independent targeting of aquaporin-2 by selective E-prostanoid receptor agonists alleviates nephrogenic diabetes insipidus.
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Abundance of tegument surface proteins in the human blood fluke Schistosoma mansoni determined by QconCAT proteomics.
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Functional characterization of three aquaglyceroporins from Trypanosoma brucei in osmoregulation and glycerol transport.
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4 July 2018
Interleukin 6 signaling promotes anti-aquaporin 4 autoantibody production from plasmablasts in neuromyelitis optica.
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4 July 2018
Aquaporin 0 enhances gap junction coupling via its cell adhesion function and interaction with connexin 50.
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4 July 2018
AAV2-mediated transfer of the human aquaporin-1 cDNA restores fluid secretion from irradiated miniature pig parotid glands
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4 July 2018
Aquaporin-3 mediates hydrogen peroxide uptake to regulate downstream intracellular signaling
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4 July 2018
Structural insights into eukaryotic aquaporin regulation.
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4 July 2018
Characterization of a novel organelle in Toxoplasma gondii with similar composition and function to the plant vacuole
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4 July 2018
Increased brain edema in aqp4-null mice in an experimental model of subarachnoid hemorrhage
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4 July 2018
Intra-cerebral injection of neuromyelitis optica immunoglobulin G and human complement produces neuromyelitis optica lesions in mice.
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4 July 2018
Aquaporin-1 tunes pain perception by interaction with Na(v)1.8 Na+ channels in dorsal root ganglion neurons
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4 July 2018
Aquaglyceroporin 9 in brain pathologies
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4 July 2018
Nitric oxide conduction by the brain aquaporin AQP4.
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4 July 2018
Automated cell-based assay for screening of aquaporin inhibitors.
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4 July 2018
Crystal Structure of a Yeast Aquaporin at 1.15 Å Reveals a Novel Gating Mechanism
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4 July 2018
Crystal structure of human aquaporin 4 at 1.8 A and its mechanism of conductance
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4 July 2018
Relative CO2/NH3 selectivities of AQP1, AQP4, AQP5, AmtB, and RhAG
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Determinants of aquaporin-4 assembly in orthogonal arrays revealed by live-cell single-molecule fluorescence imaging
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Aquaporin-4 orthogonal arrays of particles are the target for neuromyelitis optica autoantibodies
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Structural function of MIP/aquaporin 0 in the eye lens; genetic defects lead to congenital inherited cataracts
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4 July 2018
Role of aquaporin-7 and aquaporin-9 in glycerol metabolism; involvement in obesity
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4 July 2018
Dynamics and energetics of permeation through aquaporins. What do we learn from molecular dynamics simulations?
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4 July 2018
Hsp90 inhibitor partially corrects nephrogenic diabetes insipidus in a conditional knock-in mouse model of aquaporin-2 mutation
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4 July 2018
Congenital nephrogenic diabetes insipidus: what can we learn from mouse models?
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4 July 2018
Membrane proteins: molecular dynamics simulations.
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4 July 2018
A cautionary note on cosmetics containing ingredients that increase aquaporin-3 expression
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4 July 2018
Aquaporins--new players in cancer biology
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4 July 2018
Greatly improved neurological outcome after spinal cord compression injury in AQP4-deficient mice.
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4 July 2018
Is TEA an inhibitor for human Aquaporin-1?
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
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4 July 2018
Aquaporins and cell migration.
1 reference
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PubMed Central
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4 July 2018
Aquaporin-3 facilitates epidermal cell migration and proliferation during wound healing
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
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4 July 2018
Prevention of skin tumorigenesis and impairment of epidermal cell proliferation by targeted aquaporin-3 gene disruption
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PubMed Central
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4 July 2018
Pathogenic potential of IgG binding to water channel extracellular domain in neuromyelitis optica
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
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4 July 2018
The structural basis of water permeation and proton exclusion in aquaporins
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PubMed Central
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4 July 2018
The spectrum of neuromyelitis optica
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PubMed Central
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4 July 2018
Aquaporin 9 is the major pathway for glycerol uptake by mouse erythrocytes, with implications for malarial virulence
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
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4 July 2018
Impaired enterocyte proliferation in aquaporin-3 deficiency in mouse models of colitis
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
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4 July 2018
Expression of the water channel protein aquaporin-9 in malignant brain tumors
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
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4 July 2018
Anatomical and functional analysis of aquaporin 1, a water channel in primary afferent neurons
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
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4 July 2018
Identification of arylsulfonamides as Aquaporin 4 inhibitors
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PubMed Central
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4 July 2018
The structure of aquaporins
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
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4 July 2018
Increased migration and metastatic potential of tumor cells expressing aquaporin water channels
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
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4 July 2018
The barrier for proton transport in aquaporins as a challenge for electrostatic models: the role of protein relaxation in mutational calculations
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
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4 July 2018
Hereditary polyuric disorders: new concepts and differential diagnosis.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
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4 July 2018
Aquaporin-1 transports NO across cell membranes
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
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4 July 2018
Origins of proton transport behavior from selectivity domain mutations of the aquaporin-1 channel
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
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4 July 2018
Acetazolamide inhibits osmotic water permeability by interaction with aquaporin-1.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
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4 July 2018
Impaired pain sensation in mice lacking Aquaporin-1 water channels
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
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4 July 2018
Dihydroxyacetone and methylglyoxal as permeants of the Plasmodium aquaglyceroporin inhibit parasite proliferation
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
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4 July 2018
Point mutations in the aromatic/arginine region in aquaporin 1 allow passage of urea, glycerol, ammonia, and protons
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
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4 July 2018
Transfer of the AQP1 cDNA for the correction of radiation-induced salivary hypofunction.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
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4 July 2018
Differential expression of aquaporin 7 in adipose tissue of lean and obese high fat consumers.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
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4 July 2018
Disruption of aquaporin-11 produces polycystic kidneys following vacuolization of the proximal tubule
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
retrieved
4 July 2018
IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
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4 July 2018
Aquaporin 7 deficiency is associated with development of obesity through activation of adipose glycerol kinase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
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4 July 2018
The dynamics and energetics of water permeation and proton exclusion in aquaporins
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
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4 July 2018
ZINC--a free database of commercially available compounds for virtual screening
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
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4 July 2018
A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
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4 July 2018
Expression of aquaporin water channels in mouse spinal cord
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
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4 July 2018
Redistribution of aquaporin-4 in human glioblastoma correlates with loss of agrin immunoreactivity from brain capillary basal laminae
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
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4 July 2018
What really prevents proton transport through aquaporin? Charge self-energy versus proton wire proposals
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
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4 July 2018
Delayed K+ clearance associated with aquaporin-4 mislocalization: phenotypic defects in brains of alpha-syntrophin-null mice
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
retrieved
4 July 2018
Sevenfold-reduced osmotic water permeability in primary astrocyte cultures from AQP-4-deficient mice, measured by a fluorescence quenching method
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
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4 July 2018
Glycerol replacement corrects defective skin hydration, elasticity, and barrier function in aquaporin-3-deficient mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
retrieved
4 July 2018
AQP3 deficiency in humans and the molecular basis of a novel blood group system, GIL
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
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4 July 2018
Aquaporin Z of Escherichia coli: reassessment of its regulation and physiological role
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
retrieved
4 July 2018
Cloning and identification of a new member of water channel (AQP10) as an aquaglyceroporin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
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4 July 2018
Localization of aquaporin-5 in sweat glands and functional analysis using knockout mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
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4 July 2018
Aquaporin deletion in mice reduces intraocular pressure and aqueous fluid production
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
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4 July 2018
New roles for old holes: ion channel function in aquaporin-1
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
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4 July 2018
Aquaporin-4 expression is increased in oedematous human brain tumours.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
retrieved
4 July 2018
Structural basis of water-specific transport through the AQP1 water channel
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
retrieved
4 July 2018
Defective urinary concentrating ability due to a complete deficiency of aquaporin-1.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
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4 July 2018
Green fluorescent protein-based halide indicators with improved chloride and iodide affinities
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
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4 July 2018
Impaired hearing in mice lacking aquaporin-4 water channels
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
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4 July 2018
Structure of a glycerol-conducting channel and the basis for its selectivity
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
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4 July 2018
Structural determinants of water permeation through aquaporin-1
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
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4 July 2018
Tear secretion by lacrimal glands in transgenic mice lacking water channels AQP1, AQP3, AQP4 and AQP5.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
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4 July 2018
Skeletal muscle function and water permeability in aquaporin-4 deficient mice
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
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4 July 2018
Missense mutations in MIP underlie autosomal dominant 'polymorphic' and lamellar cataracts linked to 12q
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
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4 July 2018
Inhibition of aquaporin-1 water permeability by tetraethylammonium: involvement of the loop E pore region
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
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4 July 2018
Pharmacological chaperones rescue cell-surface expression and function of misfolded V2 vasopressin receptor mutants
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
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4 July 2018
Nephrogenic diabetes insipidus in mice lacking aquaporin-3 water channels.
1 reference
stated in
PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
retrieved
4 July 2018
Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
retrieved
4 July 2018
Requirement of aquaporin-1 for NaCl-driven water transport across descending vasa recta
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
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4 July 2018
Functional and molecular characterization of the human neutral solute channel aquaporin-9.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
retrieved
4 July 2018
Defective secretion of saliva in transgenic mice lacking aquaporin-5 water channels
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
retrieved
4 July 2018
Reduced water permeability and altered ultrastructure in thin descending limb of Henle in aquaporin-1 null mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
retrieved
4 July 2018
Direct immunogold labeling of aquaporin-4 in square arrays of astrocyte and ependymocyte plasma membranes in rat brain and spinal cord
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
retrieved
4 July 2018
Defective proximal tubular fluid reabsorption in transgenic aquaporin-1 null mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
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4 July 2018
Defective aquaporin-2 trafficking in nephrogenic diabetes insipidus and correction by chemical chaperones
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
retrieved
4 July 2018
Severely impaired urinary concentrating ability in transgenic mice lacking aquaporin-1 water channels
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
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4 July 2018
Aquaporins in complex tissues. II. Subcellular distribution in respiratory and glandular tissues of rat
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
retrieved
4 July 2018
Plasma membrane water permeability of cultured cells and epithelia measured by light microscopy with spatial filtering
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
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4 July 2018
Generation and phenotype of a transgenic knockout mouse lacking the mercurial-insensitive water channel aquaporin-4.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
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4 July 2018
Very high single channel water permeability of aquaporin-4 in baculovirus-infected insect cells and liposomes reconstituted with purified aquaporin-4.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
retrieved
4 July 2018
Specialized membrane domains for water transport in glial cells: high-resolution immunogold cytochemistry of aquaporin-4 in rat brain.
1 reference
stated in
PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
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4 July 2018
Cell volume and plasma membrane osmotic water permeability in epithelial cell layers measured by interferometry
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
retrieved
4 July 2018
A point mutation at cysteine 189 blocks the water permeability of rat kidney water channel CHIP28k
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
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4 July 2018
Requirement of human renal water channel aquaporin-2 for vasopressin-dependent concentration of urine
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
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4 July 2018
Cell volume measured by total internal reflection microfluorimetry: application to water and solute transport in cells transfected with water channel homologs
1 reference
stated in
PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
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4 July 2018
Functional characterization of the Escherichia coli glycerol facilitator, GlpF, in Xenopus oocytes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
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4 July 2018
Molecular cloning of a mercurial-insensitive water channel expressed in selected water-transporting tissues
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
retrieved
4 July 2018
Expression of mRNA coding for kidney and red cell water channels in Xenopus oocytes
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
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4 July 2018
Epinephrine stimulates fluid absorption across bovine retinal pigment epithelium
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
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4 July 2018
Appearance of water channels in Xenopus oocytes expressing red cell CHIP28 protein
1 reference
stated in
PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
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4 July 2018
Mutation in AQP5, encoding aquaporin 5, causes palmoplantar keratoderma Bothnia type
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
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30 October 2018
Aquaporin inhibition by gold(III) compounds: new insights
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
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30 October 2018
Aquaporin 5 promotes the proliferation and migration of human gastric carcinoma cells.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
retrieved
30 October 2018
Discovery of novel human aquaporin-1 blockers
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
retrieved
30 October 2018
Aquaporin-9 and urea transporter-A gene deletions affect urea transmembrane passage in murine hepatocytes.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
retrieved
30 October 2018
Homozygosity for aquaporin 7 G264V in three unrelated children with hyperglyceroluria and a mild platelet secretion defect.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
retrieved
30 October 2018
Defective macrophage function in aquaporin-3 deficiency
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
retrieved
30 October 2018
Water flux through human aquaporin 1: inhibition by intracellular furosemide and maximal response with high osmotic gradients.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
retrieved
30 October 2018
Protective role of aquaporin-4 water channels after contusion spinal cord injury
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
retrieved
30 October 2018
Expression of aquaporin 5 increases proliferation and metastasis potential of lung cancer.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
retrieved
30 October 2018
Inhibition of aquaporin-1 and aquaporin-4 water permeability by a derivative of the loop diuretic bumetanide acting at an internal pore-occluding binding site
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
retrieved
30 October 2018
Membrane tension regulates water transport in yeast
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
retrieved
30 October 2018
Potential utility of aquaporin modulators for therapy of brain disorders
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
retrieved
30 October 2018
Correlation between serum thyroxine and complements in patients with multiple sclerosis and neuromyelitis optica.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
retrieved
30 October 2018
Inhibition of aquaporin 4 by antiepileptic drugs
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
retrieved
30 October 2018
Hydrating skin by stimulating biosynthesis of aquaporins.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
retrieved
30 October 2018
Urearetics: a small molecule screen yields nanomolar potency inhibitors of urea transporter UT-B.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
retrieved
30 October 2018
Water transport by GLUT2 expressed in Xenopus laevis oocytes.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
retrieved
30 October 2018
Greatly impaired migration of implanted aquaporin-4-deficient astroglial cells in mouse brain toward a site of injury
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
retrieved
30 October 2018
Aquaporin-3-dependent cell migration and proliferation during corneal re-epithelialization
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
retrieved
30 October 2018
Accelerated progression of kaolin-induced hydrocephalus in aquaporin-4-deficient mice.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
retrieved
30 October 2018
Quaternary ammonium compounds as water channel blockers. Specificity, potency, and site of action.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
retrieved
30 October 2018
Increased seizure duration and slowed potassium kinetics in mice lacking aquaporin-4 water channels.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
retrieved
30 October 2018
Involvement of aquaporin-4 in astroglial cell migration and glial scar formation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
retrieved
30 October 2018
K+ waves in brain cortex visualized using a long-wavelength K+-sensing fluorescent indicator.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
retrieved
30 October 2018
Aquaporin-4 gene deletion in mice increases focal edema associated with staphylococcal brain abscess.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
retrieved
30 October 2018
NH3 and NH4+ permeability in aquaporin-expressing Xenopus oocytes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
retrieved
30 October 2018
Impairment of angiogenesis and cell migration by targeted aquaporin-1 gene disruption.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
retrieved
30 October 2018
Progressive adipocyte hypertrophy in aquaporin-7-deficient mice: adipocyte glycerol permeability as a novel regulator of fat accumulation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
retrieved
30 October 2018
Aquaporin-4 gene disruption in mice reduces brain swelling and mortality in pneumococcal meningitis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
retrieved
30 October 2018
Reduced cerebrospinal fluid production and intracranial pressure in mice lacking choroid plexus water channel Aquaporin-1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
retrieved
30 October 2018
Aquaporin-4 facilitates reabsorption of excess fluid in vasogenic brain edema.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
retrieved
30 October 2018
Effects of acetazolamide and anordiol on osmotic water permeability in AQP1-cRNA injected Xenopus oocyte.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
retrieved
30 October 2018
New potent inhibitors of aquaporins: silver and gold compounds inhibit aquaporins of plant and human origin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
retrieved
30 October 2018
Increased aquaporin 1 water channel expression in human brain tumours.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
retrieved
30 October 2018
Impaired stratum corneum hydration in mice lacking epidermal water channel aquaporin-3.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
retrieved
30 October 2018
Mildly abnormal retinal function in transgenic mice without Müller cell aquaporin-4 water channels
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
retrieved
30 October 2018
Aquaporin-5 dependent fluid secretion in airway submucosal glands
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
retrieved
30 October 2018
Neonatal mortality in an aquaporin-2 knock-in mouse model of recessive nephrogenic diabetes insipidus
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
retrieved
30 October 2018
Water channel (aquaporin 1) expression and distribution in mammary carcinomas and glioblastomas
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
retrieved
30 October 2018
The mercury-sensitive residue at cysteine 189 in the CHIP28 water channel.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4067137
retrieved
30 October 2018
Membrane stress causes inhibition of water channels in brush border membrane vesicles from kidney proximal tubule
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNRD4226
retrieved
31 March 2020
Specific aquaporins facilitate the diffusion of hydrogen peroxide across membranes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNRD4226
retrieved
31 March 2020
Inhibition of water and solute permeability in human red cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNRD4226
retrieved
31 March 2020
Novel therapeutic targets in Plasmodium falciparum: aquaglyceroporins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNRD4226
retrieved
31 March 2020
Evidence for the presence of aquaporin-3 in human red blood cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNRD4226
retrieved
31 March 2020
Physiology and pathophysiology of renal aquaporins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNRD4226
retrieved
31 March 2020
Downregulation in aquaporin 4 and aquaporin 8 expression of the colon associated with the induction of allergic diarrhea in a mouse model of food allergy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNRD4226
retrieved
31 March 2020
Identifiers
DOI
10.1038/NRD4226
1 reference
stated in
Europe PubMed Central
PMC publication ID
4067137
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24625825%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 March 2020
PMC publication ID
4067137
1 reference
stated in
Europe PubMed Central
PMC publication ID
4067137
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24625825%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 March 2020
PubMed publication ID
24625825
1 reference
stated in
Europe PubMed Central
PMC publication ID
4067137
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24625825%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 March 2020
ResearchGate publication ID
260808559
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