(Q33799555)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20147746%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

review article

3 references

2 November 2020

6 November 2020

Chemical inducers of autophagy that enhance the clearance of mutant proteins in neurodegenerative diseases (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20147746%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

1 reference

2 November 2020

5 references

25 April 2019

20 June 2019

30 June 2019

8 September 2019

14 September 2019

regulation of gene expression

1 reference

8 September 2019

1 reference

14 September 2019

1 reference

6 November 2020

Maria Jimenez-Sanchez

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20147746%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

Sovan Sarkar

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20147746%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

author name string

Maurizio Renna

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20147746%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

David C Rubinsztein

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20147746%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

language of work or name

English

0 references

publication date

10 February 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20147746%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

18 January 2020

9 April 2010

2 references

2 November 2020

6 November 2020

8 references

25 April 2019

20 June 2019

30 June 2019

8 September 2019

14 September 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20147746%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

2 November 2020

6 November 2020

285

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20147746%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

issue

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20147746%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

page(s)

11061-11067

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20147746%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution-NonCommercial

18 January 2020

copyright license

7 references

25 April 2019

20 June 2019

30 June 2019

8 September 2019

14 September 2019

2 November 2020

6 November 2020

on focus list of Wikimedia project

ScienceSource

0 references

cites work

Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856980

Autophagy, Immunity, and Microbial Adaptations

4 July 2018

1 reference

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Mammalian macroautophagy at a glance

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856980

The inositol 1,4,5-trisphosphate receptor regulates autophagy through its interaction with Beclin 1.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856980

ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856980

ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856980

Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856980

Lithium induces clearance of protease resistant prion protein in prion-infected cells by induction of autophagy

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856980

Autophagy induction by trehalose counteracts cellular prion infection

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856980

Methodological considerations for assessing autophagy modulators: a study with calcium phosphate precipitates

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856980

An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856980

Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856980

Induction of macroautophagy by exogenously introduced calcium

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856980

Huntington's disease: from pathology and genetics to potential therapies

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856980

Autophagy fights disease through cellular self-digestion

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856980

Lithium delays progression of amyotrophic lateral sclerosis

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856980

The itinerary of autophagosomes: from peripheral formation to kiss-and-run fusion with lysosomes

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856980

Small molecule regulators of autophagy identified by an image-based high-throughput screen

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856980

HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856980

Small molecules enhance autophagy and reduce toxicity in Huntington's disease models.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856980

Potential therapeutic applications of autophagy

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856980

Regulation of autophagy by the inositol trisphosphate receptor

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856980

Control of macroautophagy by calcium, calmodulin-dependent kinase kinase-beta, and Bcl-2.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856980

Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856980

The roles of intracellular protein-degradation pathways in neurodegeneration

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856980

TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856980

Loss of autophagy in the central nervous system causes neurodegeneration in mice

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856980

Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856980

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856980

Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856980

Lithium induces autophagy by inhibiting inositol monophosphatase

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856980

Increased susceptibility of cytoplasmic over nuclear polyglutamine aggregates to autophagic degradation

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856980

Dynein mutations impair autophagic clearance of aggregate-prone proteins

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856980

Lithium neuroprotection: molecular mechanisms and clinical implications

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856980

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856980

Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856980

Protein aggregation and neurodegenerative disease

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856980

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856980

Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington disease

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856980

Raised intracellular glucose concentrations reduce aggregation and cell death caused by mutant huntingtin exon 1 by decreasing mTOR phosphorylation and inducing autophagy

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856980

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856980

A common mechanism of action for three mood-stabilizing drugs

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856980

Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856980

Lessons from animal models of Huntington's disease

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856980

Phospholipase C(epsilon): a novel Ras effector

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856980

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856980

Glutamine repeats and neurodegeneration

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856980

Persistent activation of Gsalpha through limited proteolysis by calpain

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856980

Inositol trisphosphate and calcium signalling

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856980

Loss of wild-type huntingtin influences motor dysfunction and survival in the YAC128 mouse model of Huntington disease

4 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R109.072181

α-Synuclein Is Degraded by Both Autophagy and the Proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R109.072181

Rapamycin alleviates toxicity of different aggregate-prone proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R109.072181

Autophagic clearance of aggregate-prone proteins associated with neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R109.072181

The pharmacology of mTOR inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R109.072181

Autophagy regulates the processing of amino terminal huntingtin fragments

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R109.072181

Rapamycin pre-treatment protects against apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R109.072181

Valproate decreases inositol biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R109.072181

A rational mechanism for combination treatment of Huntington's disease using lithium and rapamycin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R109.072181

Novel targets for Huntington's disease in an mTOR-independent autophagy pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R109.072181

In search of an "autophagomometer".

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R109.072181

Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R109.072181

Glycogen synthase kinase-3beta inhibitors prevent cellular polyglutamine toxicity caused by the Huntington's disease mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R109.072181

Small molecule enhancers of rapamycin-induced TOR inhibition promote autophagy, reduce toxicity in Huntington's disease models and enhance killing of mycobacteria by macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R109.072181

Dependence of hepatocytic autophagy on intracellularly sequestered calcium

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20147746

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.R109.072181

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20147746%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20147746%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

1 reference