(Q33811207)

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Chiral kinase inhibitors

scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

29 July 2017

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Europe PubMed Central

Chiral kinase inhibitors (English)

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

1 reference

based on heuristic

inferred from title

Craig J. Thomas

object named as

Craig J Thomas

3

1 reference

ORCID Public Data File 2021

author name string

Jian-kang Jiang

1

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Min Shen

2

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Mathew B Boxer

4

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

publication date

1 January 2011

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Current Topics in Medicinal Chemistry

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Europe PubMed Central

PubMed publication ID

29 July 2017

11

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

7

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

800-809

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Structure-guided design of potent and selective pyrimidylpyrrole inhibitors of extracellular signal-regulated kinase (ERK) using conformational control

1 reference

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The p38alpha kinase plays a central role in inflammation

1 reference

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1 reference

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Successful structure-based design of recent p38 MAP kinase inhibitors.

1 reference

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Factors underlying sensitivity of cancers to small-molecule kinase inhibitors

1 reference

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Structural bioinformatics-based prediction of exceptional selectivity of p38 MAP kinase inhibitor PH-797804

1 reference

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Inhibitor hijacking of Akt activation

1 reference

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Dissecting specificity in the Janus kinases: the structures of JAK-specific inhibitors complexed to the JAK1 and JAK2 protein tyrosine kinase domains

1 reference

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Examining the chirality, conformation and selective kinase inhibition of 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile (CP-690,550)

1 reference

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Small molecule p38 MAP kinase inhibitors for the treatment of inflammatory diseases: novel structures and developments during 2006-2008.

1 reference

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Targeting the PI3K-AKT-mTOR pathway: progress, pitfalls, and promises

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4 July 2018

Identification of 4-aminopyrazolylpyrimidines as potent inhibitors of Trk kinases

1 reference

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Therapeutic targeting of Janus kinases

1 reference

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4 July 2018

High-throughput kinase profiling as a platform for drug discovery

1 reference

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Concurrent inhibition of kit- and FcepsilonRI-mediated signaling: coordinated suppression of mast cell activation

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The p38 mitogen-activated protein kinase (MAPK) pathway in rheumatoid arthritis

1 reference

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A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development

1 reference

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Targeting protein multiple conformations: a structure-based strategy for kinase drug design

1 reference

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Recent advances of MEK inhibitors and their clinical progress

1 reference

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Recent progress in the development of ATP-competitive and allosteric Akt kinase inhibitors

1 reference

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4 July 2018

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1 reference

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4 July 2018

Syntheses of potent, selective, and orally bioavailable indazole-pyridine series of protein kinase B/Akt inhibitors with reduced hypotension

1 reference

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4 July 2018

Flipped out: structure-guided design of selective pyrazolylpyrrole ERK inhibitors

1 reference

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4 July 2018

Chemistry and biology of resorcylic acid lactones

1 reference

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4 July 2018

A structural comparison of inhibitor binding to PKB, PKA and PKA-PKB chimera

1 reference

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4 July 2018

Role of a cysteine residue in the active site of ERK and the MAPKK family

1 reference

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4 July 2018

Discovery of 2-pyrimidyl-5-amidothiophenes as potent inhibitors for AKT: synthesis and SAR studies

1 reference

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4 July 2018

Tyrphostins and other tyrosine kinase inhibitors

1 reference

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4 July 2018

Discovery of novel isothiazole inhibitors of the TrkA kinase: structure-activity relationship, computer modeling, optimization, and identification of highly potent antagonists

1 reference

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4 July 2018

Akt/PKB signaling in cancer: a function in cell motility and invasion

1 reference

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4 July 2018

New approaches to the treatment of inflammatory disorders small molecule inhibitors of p38 MAP kinase.

1 reference

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4 July 2018

Inhibition of PI3K/Akt signaling: an emerging paradigm for targeted cancer therapy

1 reference

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4 July 2018

AKT crystal structure and AKT-specific inhibitors

1 reference

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4 July 2018

The Akt/PKB pathway: molecular target for cancer drug discovery

1 reference

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4 July 2018

Perturbations of the AKT signaling pathway in human cancer

1 reference

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4 July 2018

Insulin-sensitive protein kinases (atypical protein kinase C and protein kinase B/Akt): actions and defects in obesity and type II diabetes

1 reference

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4 July 2018

Pathway to the clinic: inhibition of P38 MAP kinase. A review of ten chemotypes selected for development

1 reference

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4 July 2018

P38 MAP kinase inhibitors: evolution of imidazole-based and pyrido-pyrimidin-2-one lead classes

1 reference

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4 July 2018

The biology of p38 kinase: a central role in inflammation

1 reference

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4 July 2018

p38 MAP kinase inhibitors: many are made, but few are chosen.

1 reference

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4 July 2018

Features of selective kinase inhibitors

1 reference

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Expression of nerve growth factor receptors and their prognostic value in human pancreatic cancer.

1 reference

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4 July 2018

The Akt/PKB family of protein kinases: a review of small molecule inhibitors and progress towards target validation

1 reference

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4 July 2018

Emerging role of Akt kinase/protein kinase B signaling in pathophysiology of diabetes and its complications

1 reference

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4 July 2018

Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors

1 reference

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Targeting the mitogen-activated protein kinase cascade to treat cancer

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Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumor activity in cancer cells overexpressing Akt.

1 reference

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The Akt pathway: molecular targets for anti-cancer drug development

1 reference

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Trends in the development of chiral drugs

1 reference

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4 July 2018

Protein kinase inhibitors: insights into drug design from structure.

1 reference

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4 July 2018

Targeting PI3K-AKT pathway for cancer therapy

1 reference

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4 July 2018

Pseudosubstrate peptides inhibit Akt and induce cell growth inhibition

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Molecular basis of neurotrophin-receptor interactions.

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Pharmacological inhibitors of the ERK signaling pathway: application as anticancer drugs

1 reference

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4 July 2018

Targeting the PI3K-Akt pathway in human cancer: rationale and promise

1 reference

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p38 mitogen-activated protein kinase inhibitors for the treatment of chronic cardiovascular disease

1 reference

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Nerve Growth Factor: Structure, Function and Therapeutic Implications for Alzheimers Disease

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4 July 2018

Mechanism of p38 MAP kinase activation in vivo.

1 reference

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4 July 2018

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1 reference

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Mutational analysis of the tyrosine kinome in colorectal cancers

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1 reference

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1 reference

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4 July 2018

A pivotal role for ERK in the oncogenic behaviour of malignant melanoma?

1 reference

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4 July 2018

Regulation of cell cycle progression and apoptosis by the Ras/Raf/MEK/ERK pathway (Review).

1 reference

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Emil Fischer--unequalled classicist, master of organic chemistry research, and inspired trailblazer of biological chemistry

1 reference

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1 reference

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4 July 2018

Pyridinylimidazole based p38 MAP kinase inhibitors

1 reference

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4 July 2018

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1 reference

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4 July 2018

Jacobus Henricus van 't Hoff; Hundred Years of Impact on Stereochemistry in the Netherlands I like to warmly acknowledge the help from Professor H. A. M. Snelders for his detailed analysis of Van 't Hoff's contributions and Professor W. Drenth for h

1 reference

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1 reference

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4 July 2018

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1 reference

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4 July 2018

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

1 reference

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4 July 2018

Physiology of nerve growth factor

1 reference

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4 July 2018

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1 reference

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4 July 2018

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1 reference

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1 reference

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1 reference

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30 October 2018

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1 reference

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30 October 2018

AKT signaling in normal and malignant cells

1 reference

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30 October 2018

Tumor cell sensitization to apoptotic stimuli by selective inhibition of specific Akt/PKB family members

1 reference

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30 October 2018

Discovery of 2,3,5-trisubstituted pyridine derivatives as potent Akt1 and Akt2 dual inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220195

30 October 2018

Prevention of Organ Allograft Rejection by a Specific Janus Kinase 3 Inhibitor

1 reference

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30 October 2018

Rational basis for Trk inhibition therapy for prostate cancer.

1 reference

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30 October 2018

3-Deoxy-D-myo-inositol 1-phosphate, 1-phosphonate, and ether lipid analogues as inhibitors of phosphatidylinositol-3-kinase signaling and cancer cell growth

1 reference

https://pubmed.ncbi.nlm.nih.gov/21291394

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Resorcylic acid lactones: naturally occurring potent and selective inhibitors of MEK

1 reference

https://pubmed.ncbi.nlm.nih.gov/21291394

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/21291394

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.2174/156802611795165052

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

ResearchGate publication ID

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