(Q33811937)

29 July 2017

title

In vitro and in vivo pharmacokinetic characterizations of AMG 900, an orally bioavailable small molecule inhibitor of aurora kinases (English)

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29 July 2017

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Liyue Huang

1

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29 July 2017

Xuhai Be

2

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29 July 2017

Loren Berry

3

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29 July 2017

Earl Moore

4

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29 July 2017

Brett Janosky

5

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29 July 2017

Mary Wells

6

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29 July 2017

Wei-Jian Pan

7

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29 July 2017

Zhiyang Zhao

8

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29 July 2017

Min-Hwa Jasmine Lin

9

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29 July 2017

language of work or name

English

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publication date

4 February 2011

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29 July 2017

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29 July 2017

volume

41

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29 July 2017

issue

5

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29 July 2017

page(s)

400-408

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Aurora kinases: shining lights on the therapeutic horizon?

29 July 2017

cites work

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https://api.crossref.org/works/10.3109%2F00498254.2010.548534

Interspecies scaling, allometry, physiological time, and the ground plan of pharmacokinetics.

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Metabolism and disposition of dasatinib after oral administration to humans

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Aurora kinases as anticancer drug targets

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https://api.crossref.org/works/10.3109%2F00498254.2010.548534

Relationship between passive permeability, efflux, and predictability of clearance from in vitro metabolic intrinsic clearance

21 January 2018

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https://api.crossref.org/works/10.3109%2F00498254.2010.548534

Overexpression and amplification of Aurora-A in hepatocellular carcinoma

21 January 2018

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Cell cycle-dependent expression and centrosome localization of a third human aurora/Ipl1-related protein kinase, AIK3

21 January 2018

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https://api.crossref.org/works/10.3109%2F00498254.2010.548534

21 January 2018

Aurora kinase inhibitors

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https://api.crossref.org/works/10.3109%2F00498254.2010.548534

Integration of in vitro data into allometric scaling to predict hepatic metabolic clearance in man: application to 10 extensively metabolized drugs

21 January 2018

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Current methods for predicting human food effect

21 January 2018

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Interspecies scaling: predicting volumes, mean residence time and elimination half-life. Some suggestions.

21 January 2018

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Interspecies scaling: predicting clearance of drugs in humans. Three different approaches

21 January 2018

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Predicting pharmacokinetics of drugs using physiologically based modeling--application to food effects

21 January 2018

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https://api.crossref.org/works/10.3109%2F00498254.2010.548534

Preclinical evaluation of AMG 900, a novel potent and highly selective pan-aurora kinase inhibitor with activity in taxane-resistant tumor cell lines

21 January 2018

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Discovery and development of aurora kinase inhibitors as anticancer agents

21 January 2018

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A unified model for predicting human hepatic, metabolic clearance from in vitro intrinsic clearance data in hepatocytes and microsomes

21 January 2018

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P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs

21 January 2018

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Intermittent target inhibition with dasatinib 100 mg once daily preserves efficacy and improves tolerability in imatinib-resistant and -intolerant chronic-phase chronic myeloid leukemia

21 January 2018

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Effects of food on the clinical pharmacokinetics of anticancer agents: underlying mechanisms and implications for oral chemotherapy

21 January 2018

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Overexpression of Aurora-A contributes to malignant development of human esophageal squamous cell carcinoma

21 January 2018

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A comprehensive quantitative and qualitative evaluation of extrapolation of intravenous pharmacokinetic parameters from rat, dog, and monkey to humans. I. Clearance.

21 January 2018

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A novel liquid chromatography/tandem mass spectrometry based depletion method for measuring red blood cell partitioning of pharmaceutical compounds in drug discovery

21 January 2018

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10.3109/00498254.2010.548534

21 January 2018

Identifiers

DOI

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29 July 2017

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