(Q33812686)

29 July 2017

title

Application of a fluorescence-based continuous-flow bioassay to screen for diversity of cytochrome P450 BM3 mutant libraries (English)

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29 July 2017

Jelle Reinen

1

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29 July 2017

Suilan Ferman

2

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29 July 2017

Eduardo Vottero

3

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29 July 2017

Nico P E Vermeulen

4

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29 July 2017

Jan N M Commandeur

5

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29 July 2017

publication date

1 February 2011

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Journal of Biomolecular Screening

29 July 2017

published in

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29 July 2017

volume

16

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29 July 2017

issue

2

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29 July 2017

page(s)

239-250

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Structure and chemistry of cytochrome P450.

29 July 2017

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P450 BM3: the very model of a modern flavocytochrome

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Protein engineering of Bacillus megaterium CYP102. The oxidation of polycyclic aromatic hydrocarbons

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Altering the regioselectivity of the subterminal fatty acid hydroxylase P450 BM-3 towards gamma- and delta-positions

21 January 2018

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Rational design of a minimal and highly enriched CYP102A1 mutant library with improved regio-, stereo- and chemoselectivity

21 January 2018

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Stereoselective hydroxylation of an achiral cyclopentanecarboxylic acid derivative using engineered P450s BM-3.

21 January 2018

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Application of drug metabolising mutants of cytochrome P450 BM3 (CYP102A1) as biocatalysts for the generation of reactive metabolites

21 January 2018

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Trimethoprim: novel reactive intermediates and bioactivation pathways by cytochrome p450s

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Generation of human metabolites of 7-ethoxycoumarin by bacterial cytochrome P450 BM3.

21 January 2018

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Generation of the human metabolite piceatannol from the anticancer-preventive agent resveratrol by bacterial cytochrome P450 BM3.

21 January 2018

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Enantioselective alpha-hydroxylation of 2-arylacetic acid derivatives and buspirone catalyzed by engineered cytochrome P450 BM-3.

21 January 2018

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A panel of cytochrome P450 BM3 variants to produce drug metabolites and diversify lead compounds

21 January 2018

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Regio- and enantioselective alkane hydroxylation with engineered cytochromes P450 BM-3.

21 January 2018

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Sensitive assay for laboratory evolution of hydroxylases toward aromatic and heterocyclic compounds.

21 January 2018

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Colorimetric high-throughput assay for alkene epoxidation catalyzed by cytochrome P450 BM-3 variant 139-3.

21 January 2018

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High throughput assay for cytochrome P450 BM3 for screening libraries of substrates and combinatorial mutants

21 January 2018

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Evaluation of alkoxyresorufins as fluorescent substrates for cytochrome P450 BM3 and site-directed mutants.

21 January 2018

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Development of a novel cytochrome p450 bioaffinity detection system coupled online to gradient reversed-phase high-performance liquid chromatography.

21 January 2018

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New cloning vectors and techniques for easy and rapid restriction mapping.

21 January 2018

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Determination and identification of estrogenic compounds generated with biosynthetic enzymes using hyphenated screening assays, high resolution mass spectrometry and off-line NMR.

21 January 2018

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Cytochrome P450 3A-mediated metabolism of buspirone in human liver microsomes

21 January 2018

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Automated software-guided identification of new buspirone metabolites using capillary LC coupled to ion trap and TOF mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110394180

Identification of Critical Residues in Novel Drug Metabolizing Mutants of Cytochrome P450 BM3 Using Random Mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110394180

21 January 2018

Identifiers

DOI

10.1177/1087057110394180

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29 July 2017

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