(Q35055050)

6 August 2017

title

A panel of cytochrome P450 BM3 variants to produce drug metabolites and diversify lead compounds (English)

1 reference

6 August 2017

1 reference

6

Frances H Arnold

1 reference

6 August 2017

Andrew M Sawayama

1

1 reference

6 August 2017

Michael M Y Chen

2

1 reference

6 August 2017

Palaniappan Kulanthaivel

3

1 reference

6 August 2017

Ming-Shang Kuo

4

1 reference

6 August 2017

Horst Hemmerle

5

1 reference

6 August 2017

language of work or name

English

0 references

publication date

1 November 2009

1 reference

Chemistry—A European Journal

6 August 2017

published in

1 reference

6 August 2017

volume

15

1 reference

6 August 2017

issue

43

1 reference

6 August 2017

page(s)

11723-11729

1 reference

A predictably selective aliphatic C-H oxidation reaction for complex molecule synthesis

6 August 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3118466

A diverse family of thermostable cytochrome P450s created by recombination of stabilizing fragments

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3118466

Diversification of catalytic function in a synthetic family of chimeric cytochrome p450s

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3118466

Enantioselective alpha-hydroxylation of 2-arylacetic acid derivatives and buspirone catalyzed by engineered cytochrome P450 BM-3.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3118466

Enantioselective epoxidation of terminal alkenes to (R)- and (S)-epoxides by engineered cytochromes P450 BM-3.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3118466

Biocatalytic production of perillyl alcohol from limonene by using a novel Mycobacterium sp. cytochrome P450 alkane hydroxylase expressed in Pseudomonas putida

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3118466

Crystal structure of P450cin in a complex with its substrate, 1,8-cineole, a close structural homologue to D-camphor, the substrate for P450cam.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3118466

57 varieties: the human cytochromes P450.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3118466

THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3118466

A self-sufficient peroxide-driven hydroxylation biocatalyst

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3118466

Understanding and exploiting C-H bond activation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3118466

Laboratory evolution of peroxide-mediated cytochrome P450 hydroxylation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3118466

Cytochrome P-450 3A4: regulation and role in drug metabolism

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3118466

Directed evolution of a para-nitrobenzyl esterase for aqueous-organic solvents

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3118466

Construction of catalase deficient Escherichia coli strains for the production of uricase.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3118466

The properties of known drugs. 1. Molecular frameworks

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3118466

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)

8 July 2018

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3118466

8 July 2018

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/CHEM.200900643

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3118466

Astemizole. A review of its pharmacodynamic properties and therapeutic efficacy

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3118466

New antihistaminic N-heterocyclic 4-piperidinamines. 2. Synthesis and antihistaminic activity of 1-[(4-fluorophenyl)methyl]-N-(4-piperidinyl)-1H-benzimidazol-2-a mines

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3118466

Characterization of a catalytically self-sufficient 119,000-dalton cytochrome P-450 monooxygenase induced by barbiturates in Bacillus megaterium.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3118466

Verapamil. An updated review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in hypertension

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3118466

Expression and enzymatic activity of recombinant cytochrome P450 17 alpha-hydroxylase in Escherichia coli

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3118466

The metabolism of DL-[14C]verapamil in man

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3118466

Organometallic chemistry: C-H activation.

8 July 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.200900643

Alkane C–H activation and functionalization with homogeneous transition metal catalysts: a century of progress—a new millennium in prospect

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.200900643

Pharmacological characterization of 4-hydroxy-N-desmethyl tamoxifen, a novel active metabolite of tamoxifen

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.200900643

Selective hydroxylation of highly branched fatty acids and their derivatives by CYP102A1 from Bacillus megaterium.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.200900643

Phenylalanine 393 exerts thermodynamic control over the heme of flavocytochrome P450 BM3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.200900643

Structure-guided recombination creates an artificial family of cytochromes P450.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.200900643

Laboratory evolution of a soluble, self-sufficient, highly active alkane hydroxylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.200900643

Regio- and enantioselective alkane hydroxylation with engineered cytochromes P450 BM-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.200900643

Preparation of human metabolites of propranolol using laboratory-evolved bacterial cytochromes P450.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.200900643

A P450 BM-3 mutant hydroxylates alkanes, cycloalkanes, arenes and heteroarenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.200900643

Hydroxylation activity of P450 BM-3 mutant F87V towards aromatic compounds and its application to the synthesis of hydroquinone derivatives from phenolic compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.200900643

Engineered alkane-hydroxylating cytochrome P450(BM3) exhibiting nativelike catalytic properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.200900643

Total biosynthesis of hydrocortisone from a simple carbon source in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.200900643

High-throughput screen for aromatic hydroxylation

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3118466

Identification of Critical Residues in Novel Drug Metabolizing Mutants of Cytochrome P450 BM3 Using Random Mutagenesis

25 October 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.200900643

Alteration of mouse cytochrome P450coh substrate specificity by mutation of a single amino-acid residue

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.200900643

C-H bond functionalization in complex organic synthesis

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19774562

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The 2.6-A crystal structure of Pseudomonas putida cytochrome P-450

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19774562

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Rational re-design of the substrate binding site of flavocytochrome P450 BM3

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19774562

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1002/CHEM.200900643

1 reference

6 August 2017

1 reference

6 August 2017

1 reference