(Q33819340)

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A Novel Small Molecule GDNF Receptor RET Agonist, BT13, Promotes Neurite Growth from Sensory Neurons in Vitro and Attenuates Experimental Neuropathy in the Rat.

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29 July 2017

A Novel Small Molecule GDNF Receptor RET Agonist, BT13, Promotes Neurite Growth from Sensory Neurons in Vitro and Attenuates Experimental Neuropathy in the Rat. (English)

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29 July 2017

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3 June 2020

Maxim M Bespalov

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3 June 2020

Peregrine B. Osborne

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3 June 2020

Viljami Jokinen

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Viljami Jokinen

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Oleg Kambur

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Ilida Suleymanova

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Ilida Suleymanova

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Agnes W Wong

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3 June 2020

Gunnar Karelson

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Mati Karelson

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3 June 2020

Janet R Keast

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3 June 2020

Eija A Kalso

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Mart Saarma

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3 June 2020

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21 June 2017

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29 July 2017

Frontiers in Pharmacology

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3 June 2020

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3 June 2020

365

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3 June 2020

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1 reference

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Pharmacokinetics and pharmacodynamics of multiple doses of BG00010, a neurotrophic factor with anti-hyperalgesic effects, in patients with sciatica

1 reference

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GDNF Overexpression from the Native Locus Reveals its Role in the Nigrostriatal Dopaminergic System Function

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Neuropathic pain as part of chronic widespread pain: environmental and genetic influences

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4 July 2018

First-In-Human, Double-Blind, Placebo-Controlled, Randomized, Dose-Escalation Study of BG00010, a Glial Cell Line-Derived Neurotrophic Factor Family Member, in Subjects with Unilateral Sciatica

1 reference

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4 July 2018

Peripherally increased artemin is a key regulator of TRPA1/V1 expression in primary afferent neurons

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4 July 2018

Parkin cooperates with GDNF/RET signaling to prevent dopaminergic neuron degeneration

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4 July 2018

Neurite outgrowth in normal and injured primary sensory neurons reveals different regulation by nerve growth factor (NGF) and artemin

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4 July 2018

Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis

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4 July 2018

RET recognition of GDNF-GFRα1 ligand by a composite binding site promotes membrane-proximal self-association

1 reference

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4 July 2018

Treating small fiber neuropathy by topical application of a small molecule modulator of ligand-induced GFRα/RET receptor signaling.

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4 July 2018

Neuropathic pain in the general population: a systematic review of epidemiological studies.

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4 July 2018

Artemin induced functional recovery and reinnervation after partial nerve injury

1 reference

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4 July 2018

Characterization of bladder sensory neurons in the context of myelination, receptors for pain modulators, and acute responses to bladder inflammation

1 reference

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4 July 2018

Artemin, a glial cell line-derived neurotrophic factor family member, induces TRPM8-dependent cold pain

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Tanezumab reduces osteoarthritic hip pain: results of a randomized, double-blind, placebo-controlled phase III trial

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Co-cultures provide a new tool to probe communication between adult sensory neurons and urothelium

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4 July 2018

Nerve growth factor-mediated regulation of pain signalling and proposed new intervention strategies in clinical pain management

1 reference

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4 July 2018

GDNF induces mechanical hyperalgesia in muscle by reducing I(BK) in isolectin B4-positive nociceptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5478727

4 July 2018

Neurotrophic actions initiated by proNGF in adult sensory neurons may require peri-somatic glia to drive local cleavage to NGF

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5478727

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Epidemiology of neuropathic pain and its impact on quality of life

1 reference

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4 July 2018

Overexpression of GDNF in the uninjured DRG exerts analgesic effects on neuropathic pain following segmental spinal nerve ligation in mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5478727

4 July 2018

Taking pain out of NGF: a "painless" NGF mutant, linked to hereditary sensory autonomic neuropathy type V, with full neurotrophic activity

1 reference

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4 July 2018

Growth factors and neuropathic pain

1 reference

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4 July 2018

Heparan sulfate proteoglycan syndecan-3 is a novel receptor for GDNF, neurturin, and artemin

1 reference

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4 July 2018

1 reference

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4 July 2018

The Prevalence of Neuropathic Pain: Clinical Evaluation Compared with Screening Tools in a Community Population

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5478727

4 July 2018

Topographically specific regeneration of sensory axons in the spinal cord

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5478727

4 July 2018

Sciatic nerve injury in adult rats causes distinct changes in the central projections of sensory neurons expressing different glial cell line-derived neurotrophic factor family receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5478727

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Persephin signaling through GFRalpha1: the potential for the treatment of Parkinson's disease

1 reference

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4 July 2018

Conditioning lesions enhance growth state only in sensory neurons lacking calcitonin gene-related peptide and isolectin B4-binding.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5478727

4 July 2018

Heparin-binding determinants of GDNF reduce its tissue distribution but are beneficial for the protection of nigral dopaminergic neurons

1 reference

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4 July 2018

Spinal cord compression injury in adult rats initiates changes in dorsal horn remodeling that may correlate with development of neuropathic pain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5478727

4 July 2018

Brain derived neurotrophic factor (BDNF) contributes to the pain hypersensitivity following surgical incision in the rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5478727

4 July 2018

GDNF hyperalgesia is mediated by PLCgamma, MAPK/ERK, PI3K, CDK5 and Src family kinase signaling and dependent on the IB4-binding protein versican

1 reference

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4 July 2018

Persistent restoration of sensory function by immediate or delayed systemic artemin after dorsal root injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5478727

4 July 2018

Expression of receptors for glial cell line-derived neurotrophic factor family ligands in sacral spinal cord reveals separate targets of pelvic afferent fibers

1 reference

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Neurotrophic factor receptor RET: structure, cell biology, and inherited diseases

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4 July 2018

Cardiovascular and lifestyle risk factors in lumbar radicular pain or clinically defined sciatica: a systematic review

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4 July 2018

The function neutralizing anti-TrkA antibody MNAC13 reduces inflammatory and neuropathic pain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5478727

4 July 2018

GDNF family receptor complexes are emerging drug targets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5478727

4 July 2018

Laminin and growth factor receptor activation stimulates differential growth responses in subpopulations of adult DRG neurons

1 reference

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4 July 2018

Artemin overexpression in skin enhances expression of TRPV1 and TRPA1 in cutaneous sensory neurons and leads to behavioral sensitivity to heat and cold.

1 reference

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4 July 2018

Nerve growth factor, glial cell line-derived neurotrophic factor and neurturin prevent semaphorin 3A-mediated growth cone collapse in adult sensory neurons

1 reference

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4 July 2018

Structure of artemin complexed with its receptor GFRalpha3: convergent recognition of glial cell line-derived neurotrophic factors

1 reference

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4 July 2018

BDNF in sensory neurons and chronic pain

1 reference

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4 July 2018

Multiple actions of systemic artemin in experimental neuropathy

1 reference

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XIB4035, a novel nonpeptidyl small molecule agonist for GFRalpha-1.

1 reference

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4 July 2018

The GDNF family: signalling, biological functions and therapeutic value

1 reference

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4 July 2018

GFRalpha3 is expressed predominantly in nociceptive sensory neurons

1 reference

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4 July 2018

Released GFRalpha1 potentiates downstream signaling, neuronal survival, and differentiation via a novel mechanism of recruitment of c-Ret to lipid rafts.

1 reference

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4 July 2018

Potent analgesic effects of GDNF in neuropathic pain states.

1 reference

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4 July 2018

Positive and negative interactions of GDNF, NTN and ART in developing sensory neuron subpopulations, and their collaboration with neurotrophins

1 reference

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Regulation of cell fate decision of undifferentiated spermatogonia by GDNF.

1 reference

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4 July 2018

The glial cell line-derived neurotrophic factor family receptor components are differentially regulated within sensory neurons after nerve injury.

1 reference

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4 July 2018

Growth responses of different subpopulations of adult sensory neurons to neurotrophic factors in vitro.

1 reference

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4 July 2018

Distinct structural elements in GDNF mediate binding to GFRalpha1 and activation of the GFRalpha1-c-Ret receptor complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5478727

4 July 2018

A distinct subgroup of small DRG cells express GDNF receptor components and GDNF is protective for these neurons after nerve injury.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5478727

4 July 2018

The messenger RNAs for both glial cell line-derived neurotrophic factor receptors, c-ret and GDNFRalpha, are induced in the rat brain in response to kainate-induced excitation.

1 reference

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4 July 2018

IB4-binding DRG neurons switch from NGF to GDNF dependence in early postnatal life.

1 reference

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4 July 2018

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1 reference

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TrkB mediates BDNF/NT-3-dependent survival and proliferation in fibroblasts lacking the low affinity NGF receptor

1 reference

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4 July 2018

An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat

1 reference

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Tanezumab for the Treatment of Pain from Osteoarthritis of the Knee

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29 October 2018

Explicit Diversity Index (EDI): a novel measure for assessing the diversity of compound databases.

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29 October 2018

The neural cell adhesion molecule NCAM is an alternative signaling receptor for GDNF family ligands

1 reference

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29 October 2018

A new definition of neuropathic pain

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29 October 2018

Long-term safety and effectiveness of tanezumab as treatment for chronic low back pain

1 reference

https://pubmed.ncbi.nlm.nih.gov/28680400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of antiallodynic actions of ALE-0540, a novel nerve growth factor receptor antagonist, in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/28680400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nerve growth factors (NGF, BDNF) enhance axonal regeneration but are not required for survival of adult sensory neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/28680400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

RET(MEN 2B) is active in the endoplasmic reticulum before reaching the cell surface

1 reference

https://pubmed.ncbi.nlm.nih.gov/28680400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.3389/FPHAR.2017.00365

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28680400%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28680400%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28680400%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

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