(Q33819356)

29 July 2017

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title

RAS inhibitors in hematologic cancers: biologic considerations and clinical applications (English)

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29 July 2017

Beaupre DM

1

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29 July 2017

Kurzrock R

series ordinal

2

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29 July 2017

publication date

1 January 1999

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Investigational New Drugs

29 July 2017

published in

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29 July 2017

volume

17

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29 July 2017

issue

2

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29 July 2017

page(s)

137-143

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https://scigraph.springernature.com/pub.10.1023/a:1006319116226

29 July 2017

exact match

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cites work

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Role of interleukin-1 inhibitory molecules in therapy of acute and chronic myelogenous leukemia

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12 December 2020

The Ras antagonist S-farnesylthiosalicylic acid induces inhibition of MAPK activation

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12 December 2020

[Gene diagnosis of pancreatic adenocarcinoma]

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Differential effects of monoterpenes and lovastatin on RAS processing

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Suppression of chronic myelogenous leukemia colony growth by interleukin-1 (IL-1) receptor antagonist and soluble IL-1 receptors: a novel application for inhibitors of IL-1 activity

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12 December 2020

Genetic analysis is consistent with the hypothesis that NF1 limits myeloid cell growth through p21ras

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Inhibitors of prenyl transferases.

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Expression of normal and mutant ras proteins in human acute leukemia

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Development of highly potent inhibitors of Ras farnesyltransferase possessing cellular and in vivo activity.

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RAS and leukemia: from basic mechanisms to gene-directed therapy

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Ras and myelodysplasia: lessons from the last decade.

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K-ras oncogene activation in adenocarcinoma of the human pancreas. A study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis and allele-specific oligonucleotide hybridization

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12 December 2020

Aberrant expression of p21RAS but not p120GAP is a common feature of myelodysplasia

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12 December 2020

Low frequency of ras oncogene mutations in Philadelphia-positive acute leukemia and report of a novel mutation H61 Leu in a single case

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12 December 2020

Clinical development plan: l-perillyl alcohol

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12 December 2020

Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice

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12 December 2020

A human gastric carcinoma contains a single mutated and an amplified normal allele of the Ki-ras oncogene

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12 December 2020

Inhibitors of Ras farnesyltransferases

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12 December 2020

Inhibition of acute myelogenous leukemia blast proliferation by interleukin-1 (IL-1) receptor antagonist and soluble IL-1 receptors

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12 December 2020

Protein farnesyltransferase inhibitors block the growth of ras-dependent tumors in nude mice

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12 December 2020

Direct demonstration of geranylgeranylation and farnesylation of Ki-Ras in vivo

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12 December 2020

The ras/cholesterol connection: implications for ras oncogenicity.

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12 December 2020

The Bcr-Abl tyrosine kinase activates mitogenic signaling pathways and stimulates G1-to-S phase transition in hematopoietic cells

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12 December 2020

Homozygous inactivation of the NF1 gene in bone marrow cells from children with neurofibromatosis type 1 and malignant myeloid disorders

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12 December 2020

Detection of high incidence of H-RAS oncogene point mutations in acute myelogenous leukemia

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12 December 2020

Mutations of the N-ras gene in juvenile chronic myelogenous leukemia

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12 December 2020

BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein

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12 December 2020

Peptidomimetic inhibitors of Ras farnesylation and function in whole cells

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12 December 2020

Benzodiazepine peptidomimetic BZA-5B interrupts the MAP kinase activation pathway in H-Ras-transformed Rat-1 cells, but not in untransformed cells.

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12 December 2020

Chemotherapy of pancreatic cancer with the monoterpene perillyl alcohol

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12 December 2020

Mutations and expression of the ras family genes in leukemias

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12 December 2020

Selective inhibition of ras-dependent transformation by a farnesyltransferase inhibitor

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12 December 2020

Overexpression of the N-ras proto-oncogene, not somatic mutational activation, associated with malignant tumors in transgenic mice

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12 December 2020

ras gene Amplification and malignant transformation

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12 December 2020

N- and K-ras oncogenes in plasma cell dyscrasias.

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12 December 2020

Mutations of the NF1 gene in children with juvenile myelomonocytic leukemia without clinical evidence of neurofibromatosis, type 1.

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12 December 2020

N-ras gene point mutations in childhood acute lymphocytic leukemia correlate with a poor prognosis

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12 December 2020

The molecular genetics of Philadelphia chromosome-positive leukemias

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12 December 2020

Transformation and stimulation of DNA synthesis in NIH-3T3 cells are a titratable function of normal p21N-ras expression.

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12 December 2020

Analysis of RAS oncogene mutations in human lymphoid malignancies

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12 December 2020

Limonene-induced regression of mammary carcinomas

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12 December 2020

The inhibition of protein prenyltransferases by oxygenated metabolites of limonene and perillyl alcohol

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12 December 2020

Mammary carcinoma regression induced by perillyl alcohol, a hydroxylated analog of limonene

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12 December 2020

The catalytic domain of the neurofibromatosis type 1 gene product stimulates ras GTPase and complements ira mutants of S. cerevisiae

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12 December 2020

Autocrine interleukin-1beta production in leukemia: evidence for the involvement of mutated RAS.

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12 December 2020

Benzodiazepine peptidomimetics: potent inhibitors of Ras farnesylation in animal cells

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12 December 2020

Nf1 deficiency causes Ras-mediated granulocyte/macrophage colony stimulating factor hypersensitivity and chronic myeloid leukaemia

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12 December 2020

Farnesyltransferase inhibitors block the neurofibromatosis type I (NF1) malignant phenotype

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12 December 2020

RAS mutations are rare events in Philadelphia chromosome-negative/bcr gene rearrangement-negative chronic myelogenous leukemia, but are prevalent in chronic myelomonocytic leukemia

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12 December 2020

Potent, cell active, non-thiol tetrapeptide inhibitors of farnesyltransferase.

1 reference

12 December 2020

RAS gene mutations in acute and chronic myelocytic leukemias, chronic myeloproliferative disorders, and myelodysplastic syndromes

1 reference

12 December 2020

Structure-activity relationships among monoterpene inhibitors of protein isoprenylation and cell proliferation

1 reference

12 December 2020

Antitumor effect of a farnesyl protein transferase inhibitor in mammary and lymphoid tumors overexpressing N-ras in transgenic mice

1 reference

12 December 2020

ras activation in experimental carcinogenesis.

1 reference

12 December 2020

The pattern of mutational involvement of RAS genes in human hematologic malignancies determined by DNA amplification and direct sequencing

1 reference

12 December 2020

Malignant transformation of human fibroblasts by a transfected N-ras oncogene.

1 reference

12 December 2020

Regression of rat primary mammary tumors following dietary d-limonene

1 reference

12 December 2020

Phase I clinical trial of perillyl alcohol administered daily.

1 reference

12 December 2020

Regulation of Bcl-2 gene expression by BCR-ABL is mediated by Ras.

1 reference

12 December 2020

Pediatric myelodysplasia: a study of 68 children and a new prognostic scoring system

1 reference

12 December 2020

Proliferation of human malignant astrocytomas is dependent on Ras activation.

1 reference

12 December 2020

Clinical trials referral resource. Clinical trials with perillyl alcohol

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12 December 2020

Farnesol modification of Kirsten-ras exon 4B protein is essential for transformation

1 reference

12 December 2020

Oncogenes in multiple myeloma: point mutation of N-ras

1 reference

12 December 2020

Alterations of myc, myb, and rasHa proto-oncogenes in cancers are frequent and show clinical correlation

1 reference

12 December 2020

The BCR-ABL tyrosine kinase inhibits apoptosis by activating a Ras-dependent signaling pathway

1 reference

12 December 2020

Ras CAAX peptidomimetic FTI 276 selectively blocks tumor growth in nude mice of a human lung carcinoma with K-Ras mutation and p53 deletion.

1 reference

12 December 2020

K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors

1 reference

12 December 2020

Monosomy 7 myeloproliferative disease in children with neurofibromatosis, type 1: epidemiology and molecular analysis.

1 reference

12 December 2020

Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: synergistic action of oncogenes in vivo

1 reference

12 December 2020

Induction of apoptosis in liver tumors by the monoterpene perillyl alcohol

1 reference

12 December 2020

Cancer chemoprevention and therapy by monoterpenes

1 reference

12 December 2020

Genetic requirement for Ras in the transformation of fibroblasts and hematopoietic cells by the Bcr-Abl oncogene

1 reference

12 December 2020

Bisubstrate inhibitors of farnesyltransferase: a novel class of specific inhibitors of ras transformed cells.

1 reference

12 December 2020

Loss of NF1 results in activation of the Ras signaling pathway and leads to aberrant growth in haematopoietic cells

1 reference

12 December 2020

Role of p21 RAS in p210 bcr-abl transformation of murine myeloid cells.

1 reference

12 December 2020

Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes

1 reference

12 December 2020

Identifiers

DOI

10.1023/A:1006319116226

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Dimensions Publication ID

29 July 2017

1027769688

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