(Q33828730)

29 July 2017

title

β-Adrenergic receptor subtype signaling in heart: from bench to bedside (English)

1 reference

29 July 2017

Anthony Yiu Ho Woo

1

1 reference

29 July 2017

Rui-ping Xiao

series ordinal

2

1 reference

29 July 2017

language of work or name

1 reference

30 January 2012

1 reference

Acta Pharmacologica Sinica

29 July 2017

published in

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29 July 2017

volume

33

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29 July 2017

issue

3

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29 July 2017

page(s)

335-341

1 reference

https://scigraph.springernature.com/pub.10.1038/aps.2011.201

29 July 2017

exact match

0 references

cites work

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28 July 2018

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Comparative molecular field analysis of fenoterol derivatives: A platform towards highly selective and effective beta(2)-adrenergic receptor agonists

28 July 2018

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Therapeutic efficacy of a combination of a beta1-adrenoreceptor (AR) blocker and beta2-AR agonist in a rat model of postmyocardial infarction dilated heart failure exceeds that of a beta1-AR blocker plus angiotensin-converting enzyme inhibitor

28 July 2018

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28 July 2018

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28 July 2018

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Stereochemistry of an agonist determines coupling preference of beta2-adrenoceptor to different G proteins in cardiomyocytes

28 July 2018

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28 July 2018

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A GRK5 polymorphism that inhibits beta-adrenergic receptor signaling is protective in heart failure

28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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GPCR functional selectivity has therapeutic impact

28 July 2018

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Collateral efficacy in drug discovery: taking advantage of the good (allosteric) nature of 7TM receptors

28 July 2018

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How many drug targets are there?

28 July 2018

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28 July 2018

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28 July 2018

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Akt mediates the cross-talk between beta-adrenergic and insulin receptors in neonatal cardiomyocytes.

28 July 2018

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Beneficial effects of chronic pharmacological manipulation of beta-adrenoreceptor subtype signaling in rodent dilated ischemic cardiomyopathy

28 July 2018

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28 July 2018

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Phosphorylation of G protein-coupled receptors: GPCR kinases in heart disease

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077138

Loss of beta-adrenoceptor response in myocytes overexpressing the Na+/Ca(2+)-exchanger

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077138

Comparison of carvedilol and metoprolol on clinical outcomes in patients with chronic heart failure in the Carvedilol Or Metoprolol European Trial (COMET): randomised controlled trial

28 July 2018

1 reference

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Linkage of beta1-adrenergic stimulation to apoptotic heart cell death through protein kinase A-independent activation of Ca2+/calmodulin kinase II.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077138

Specific beta(2)AR blocker ICI 118,551 actively decreases contraction through a G(i)-coupled form of the beta(2)AR in myocytes from failing human heart.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077138

Effect of carvedilol on survival in severe chronic heart failure

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077138

Cardiac beta ARK1 inhibition prolongs survival and augments beta blocker therapy in a mouse model of severe heart failure

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077138

Dual modulation of cell survival and cell death by beta(2)-adrenergic signaling in adult mouse cardiac myocytes

28 July 2018

1 reference

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The conserved phosphoinositide 3-kinase pathway determines heart size in mice

28 July 2018

1 reference

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Preservation of myocardial beta-adrenergic receptor signaling delays the development of heart failure after myocardial infarction

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077138

Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomised Intervention Trial in Congestive Heart Failure (MERIT-HF)

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077138

Progressive hypertrophy and heart failure in beta1-adrenergic receptor transgenic mice.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077138

Reciprocal in vivo regulation of myocardial G protein-coupled receptor kinase expression by beta-adrenergic receptor stimulation and blockade

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077138

G protein-coupled receptors. III. New roles for receptor kinases and beta-arrestins in receptor signaling and desensitization

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077138

Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077138

Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077138

Mechanism of beta-adrenergic receptor desensitization in cardiac hypertrophy is increased beta-adrenergic receptor kinase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077138

G-protein-coupled receptor kinase activity is increased in hypertension

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077138

The renin-angiotensin system in left ventricular remodeling

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077138

Effect of angiotensin-converting enzyme inhibitors on ventricular remodeling and survival following myocardial infarction

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077138

Reduced beta 1 receptor messenger RNA abundance in the failing human heart

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077138

Physiological effects of inverse agonists in transgenic mice with myocardial overexpression of the beta 2-adrenoceptor

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077138

Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077138

Increase of the 40,000-mol wt pertussis toxin substrate (G protein) in the failing human heart

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077138

Beta 1- and beta 2-adrenergic receptor-mediated adenylate cyclase stimulation in nonfailing and failing human ventricular myocardium

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077138

Role of beta gamma subunits of G proteins in targeting the beta-adrenergic receptor kinase to membrane-bound receptors

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077138

Vasospastic phenomena in patients treated with beta-adrenoceptor blocking agents

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077138

Epidemiology, pathophysiology, and etiology of congestive heart failure in older adults

28 July 2018

1 reference

https://api.crossref.org/works/10.1038%2FAPS.2011.201

Executive Summary: Heart Disease and Stroke Statistics—2010 Update

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FAPS.2011.201

Activity of the sympathetic nervous system and renin-angiotensin system assessed by plasma hormone levels and their relation to hemodynamic abnormalities in congestive heart failure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FAPS.2011.201

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FAPS.2011.201

Meta-analysis: angiotensin-receptor blockers in chronic heart failure and high-risk acute myocardial infarction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FAPS.2011.201

A beta1-adrenergic receptor CaM kinase II-dependent pathway mediates cardiac myocyte fetal gene induction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FAPS.2011.201

Increased nitration of sarcoplasmic reticulum Ca2+-ATPase in human heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FAPS.2011.201

Altered expression of beta-adrenergic receptor kinase and beta 1-adrenergic receptors in the failing human heart.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FAPS.2011.201

Strain-dependent beta-adrenergic receptor function influences myocardial responses to isoproterenol stimulation in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FAPS.2011.201

Restoration of beta-adrenergic receptor signaling and contractile function in heart failure by disruption of the betaARK1/phosphoinositide 3-kinase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FAPS.2011.201

Level of beta-adrenergic receptor kinase 1 inhibition determines degree of cardiac dysfunction after chronic pressure overload-induced heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FAPS.2011.201

Enhanced G(i) signaling selectively negates beta2-adrenergic receptor (AR)--but not beta1-AR-mediated positive inotropic effect in myocytes from failing rat hearts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FAPS.2011.201

Beta-blockers in heart failure: are pharmacological differences clinically important?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FAPS.2011.201

Differential kinetic and spatial patterns of beta-arrestin and G protein-mediated ERK activation by the angiotensin II receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FAPS.2011.201

Cardioprotective and survival benefits of long-term combined therapy with beta2 adrenoreceptor (AR) agonist and beta1 AR blocker in dilated cardiomyopathy postmyocardial infarction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FAPS.2011.201

Comparative molecular field analysis of the binding of the stereoisomers of fenoterol and fenoterol derivatives to the beta2 adrenergic receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FAPS.2011.201

Functional selectivity of GPCR ligand stereoisomers: new pharmacological opportunities

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FAPS.2011.201

Gi-biased β2AR signaling links GRK2 upregulation to heart failure

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4077138

Activation of beta-adrenergic receptor kinase during myocardial ischemia

29 October 2018

1 reference

12 December 2020

Effects of metoprolol on myocardial beta-adrenoceptors and Gi alpha-proteins in patients with congestive heart failure

1 reference

12 December 2020

Influence of isoproterenol and ouabain on excitation-contraction coupling, cross-bridge function, and energetics in failing human myocardium

1 reference

12 December 2020

Coupling of beta2-adrenoceptor to Gi proteins and its physiological relevance in murine cardiac myocytes

1 reference

12 December 2020

The Cardiac Insufficiency Bisoprolol Study II (CIBIS-II): a randomised trial

1 reference

12 December 2020

The enigma of beta2-adrenergic receptor Gi signaling in the heart: the good, the bad, and the ugly

1 reference

12 December 2020

Pharmacological stimulation of beta2-adrenergic receptors (beta2AR) enhances therapeutic effectiveness of beta1AR blockade in rodent dilated ischemic cardiomyopathy

1 reference

12 December 2020

Activation of CaMKIIdeltaC is a common intermediate of diverse death stimuli-induced heart muscle cell apoptosis

1 reference

12 December 2020

β2-Adrenergic receptor-induced transactivation of epidermal growth factor receptor and platelet-derived growth factor receptor via Src kinase promotes rat cardiomyocyte survival

1 reference

12 December 2020

Expression of beta-arrestins and beta-adrenergic receptor kinases in the failing human heart

1 reference

12 December 2020

Myocardial-directed overexpression of the human beta(1)-adrenergic receptor in transgenic mice

1 reference

12 December 2020

Na+/Ca2+ exchange linking beta2-adrenergic G(i) signaling to heart failure: associated defect of adrenergic contractile support

1 reference

12 December 2020

Propranolol-induced bronchoconstriction: A non-specific side-effect of β-adrenergic blocking therapy

1 reference

12 December 2020

Decreased Catecholamine Sensitivity and β-Adrenergic-Receptor Density in Failing Human Hearts

1 reference

12 December 2020

Beta 1- and beta 2-adrenergic-receptor subpopulations in nonfailing and failing human ventricular myocardium: coupling of both receptor subtypes to muscle contraction and selective beta 1-receptor down-regulation in heart failure

1 reference

12 December 2020

Beneficial effects of metoprolol in idiopathic dilated cardiomyopathy. Metoprolol in Dilated Cardiomyopathy (MDC) Trial Study Group

1 reference

12 December 2020

Radioimmunochemical quantification of Gi alpha in right and left ventricles from patients with ischaemic and dilated cardiomyopathy and predominant left ventricular failure

1 reference

12 December 2020

Progressive ventricular remodeling in response to diffuse isoproterenol-induced myocardial necrosis in rats

1 reference

12 December 2020

Beta 2-adrenergic receptor-stimulated increase in cAMP in rat heart cells is not coupled to changes in Ca2+ dynamics, contractility, or phospholamban phosphorylation

1 reference

12 December 2020

Functional coupling of the beta 2-adrenoceptor to a pertussis toxin-sensitive G protein in cardiac myocytes

1 reference

12 December 2020

Identifiers

DOI

10.1038/APS.2011.201

1 reference

Dimensions Publication ID

29 July 2017

0 references

1 reference

29 July 2017

1 reference