(Q33851778)

English

IL-21 and IL-6 are critical for different aspects of B cell immunity and redundantly induce optimal follicular helper CD4 T cell (Tfh) differentiation

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scholarly article

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Europe PubMed Central

PubMed publication ID

29 July 2017

IL-21 and IL-6 are critical for different aspects of B cell immunity and redundantly induce optimal follicular helper CD4 T cell (Tfh) differentiation (English)

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

8

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Shane Crotty

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

author name string

Danelle Eto

1

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Christopher Lao

2

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Daniel DiToro

3

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Burton Barnett

4

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Tania C Escobar

5

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Robin Kageyama

6

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Isharat Yusuf

7

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

language of work or name

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publication date

14 March 2011

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

6

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

3

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

e17739

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

copyright license

Creative Commons Attribution 4.0 International

14 March 2011

1 reference

April 2022 Public Data File from Crossref

copyright status

0 references

Follicular helper CD4 T cells (TFH)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056724

5 July 2018

Phosphoinositide 3-kinase activity in T cells regulates the magnitude of the germinal center reaction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056724

5 July 2018

Follicular helper T cell differentiation requires continuous antigen presentation that is independent of unique B cell signaling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056724

5 July 2018

Germinal center T follicular helper cell IL-4 production is dependent on signaling lymphocytic activation molecule receptor (CD150)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056724

5 July 2018

In vivo regulation of Bcl6 and T follicular helper cell development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056724

5 July 2018

Differentiation of effector CD4 T cell populations (*)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056724

5 July 2018

IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056724

5 July 2018

IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056724

5 July 2018

Effectors and memories: Bcl-6 and Blimp-1 in T and B lymphocyte differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056724

5 July 2018

Analysis of interleukin-21-induced Prdm1 gene regulation reveals functional cooperation of STAT3 and IRF4 transcription factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056724

5 July 2018

B cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056724

5 July 2018

Bcl6 mediates the development of T follicular helper cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056724

5 July 2018

Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056724

5 July 2018

The T cell STAT signaling network is reprogrammed within hours of bacteremia via secondary signals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056724

5 July 2018

IL-6 produced by immune complex-activated follicular dendritic cells promotes germinal center reactions, IgG responses and somatic hypermutation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056724

5 July 2018

A vital role for interleukin-21 in the control of a chronic viral infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056724

5 July 2018

IL-21 is required to control chronic viral infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056724

5 July 2018

IL-4-producing CD4+ T cells in reactive lymph nodes during helminth infection are T follicular helper cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056724

5 July 2018

T follicular helper cells differentiate from Th2 cells in response to helminth antigens

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056724

5 July 2018

Cytokine-secreting follicular T cells shape the antibody repertoire

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056724

5 July 2018

The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+ T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056724

5 July 2018

Interleukin-6/STAT3 signaling regulates the ability of naive T cells to acquire B-cell help capacities

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056724

5 July 2018

The effects of IL-6 on CD4 T cell responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056724

5 July 2018

SAP-controlled T-B cell interactions underlie germinal centre formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056724

5 July 2018

A fundamental role for interleukin-21 in the generation of T follicular helper cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056724

5 July 2018

Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056724

5 July 2018

Development and characterization of IL-21-producing CD4+ T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056724

5 July 2018

Regulation and functions of Blimp-1 in T and B lymphocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056724

5 July 2018

STAT3-mediated up-regulation of BLIMP1 Is coordinated with BCL6 down-regulation to control human plasma cell differentiation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056724

5 July 2018

T follicular helper (TFH) cells in normal and dysregulated immune responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056724

5 July 2018

Interleukin-21: Basic Biology and Implications for Cancer and Autoimmunity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056724

5 July 2018

IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056724

5 July 2018

Germinal-center organization and cellular dynamics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056724

5 July 2018

Essential autocrine regulation by IL-21 in the generation of inflammatory T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056724

5 July 2018

IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056724

5 July 2018

IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056724

5 July 2018

Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056724

5 July 2018

Immunization-induced perturbation of human blood plasma cell pool: progressive maturation, IL-6 responsiveness, and high PRDI-BF1/BLIMP1 expression are critical distinctions between antigen-specific and nonspecific plasma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056724

5 July 2018

IL-21 induces differentiation of human naive and memory B cells into antibody-secreting plasma cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056724

5 July 2018

Follicular B helper T cells in antibody responses and autoimmunity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056724

5 July 2018

The role of ICOS in the CXCR5+ follicular B helper T cell maintenance in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056724

5 July 2018

Regulation of plasma-cell development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056724

5 July 2018

Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of Blimp-1 and Bcl-6

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056724

5 July 2018

T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056724

5 July 2018

Immunological memory in humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056724

5 July 2018

Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056724

5 July 2018

Principles of interleukin (IL)-6-type cytokine signalling and its regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056724

5 July 2018

SAP is required for generating long-term humoral immunity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056724

5 July 2018

A critical role for IL-21 in regulating immunoglobulin production

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056724

5 July 2018

Subspecialization of CXCR5+ T cells: B helper activity is focused in a germinal center-localized subset of CXCR5+ T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056724

5 July 2018

CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056724

5 July 2018

Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056724

5 July 2018

Interleukin 6 influences germinal center development and antibody production via a contribution of C3 complement component

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056724

5 July 2018

A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056724

5 July 2018

Endogenous interleukin 6 production in multiple myeloma patients treated with chimeric monoclonal anti-IL6 antibodies indicates the existence of a positive feed-back loop

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056724

5 July 2018

Impaired immune and acute-phase responses in interleukin-6-deficient mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056724

5 July 2018

Germinal centers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056724

5 July 2018

Interleukin-6 in human multiple myeloma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056724

5 July 2018

Biologic effects of anti-interleukin-6 murine monoclonal antibody in advanced multiple myeloma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056724

5 July 2018

Identification of a T cell-derived b cell growth factor distinct from interleukin 2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056724

5 July 2018

Serological, biochemical, and functional identity of B cell-stimulatory factor 1 and B cell differentiation factor for IgG1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056724

5 July 2018

Cytokine-induced proliferation and immunoglobulin production of human B lymphocytes triggered through their CD40 antigen

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056724

5 July 2018

The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0017739

21 January 2018

Role of CXCR5 and CCR7 in follicular Th cell positioning and appearance of a programmed cell death gene-1high germinal center-associated subpopulation.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0017739

21 January 2018

SAP regulation of follicular helper CD4 T cell development and humoral immunity is independent of SLAM and Fyn kinase.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0017739

21 January 2018

Early commitment of naïve human CD4(+) T cells to the T follicular helper (T(FH)) cell lineage is induced by IL-12.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0017739

21 January 2018

Inhibition of Th1 Differentiation by IL-6 Is Mediated by SOCS1

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0017739

21 January 2018

IL-21 inhibits IFN-gamma production in developing Th1 cells through the repression of Eomesodermin expression

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0017739

21 January 2018

Cytokine-mediated regulation of human B cell differentiation into Ig-secreting cells: predominant role of IL-21 produced by CXCR5+ T follicular helper cells.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0017739

21 January 2018

Interleukin-6 is a growth factor for nonmalignant human plasmablasts.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0017739

21 January 2018

Critical role for Stat3 in T-dependent terminal differentiation of IgG B cells.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0017739

21 January 2018

BCL-6 expression during B-cell activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056724

29 October 2018

B and T Lymphocyte Attenuator Suppresses IL-21 Production from Follicular Th Cells and Subsequent Humoral Immune Responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/21423809

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Balanced expression of CXCR5 and CCR7 on follicular T helper cells determines their transient positioning to lymph node follicles and is essential for efficient B-cell help

1 reference

https://pubmed.ncbi.nlm.nih.gov/21423809

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reactive plasmacytoses are expansions of plasmablasts retaining the capacity to differentiate into plasma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21423809

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transcriptional repressor Blimp-1 regulates T cell homeostasis and function

1 reference

https://pubmed.ncbi.nlm.nih.gov/21423809

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Follicular B helper T cell activity is confined to CXCR5(hi)ICOS(hi) CD4 T cells and is independent of CD57 expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/21423809

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0017739

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

2011PLoSO...617739E

0 references

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

ResearchGate publication ID

0 references

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