(Q33852418)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21426104%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

review article

1 reference

title

Synthesis of chemically modified bioactive peptides: recent advances, challenges and developments for medicinal chemistry (English)

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26 January 2020

2

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26 January 2020

Norbert Sewald

series ordinal

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21426104%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

author name string

Soledad Royo Gracia

series ordinal

1

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26 January 2020

publication date

1 October 2009

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21426104%20AND%20SRC:MED&resulttype=core&format=json

Future Medicinal Chemistry

26 January 2020

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21426104%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

volume

1

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26 January 2020

issue

7

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26 January 2020

page(s)

1289-1310

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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

26 January 2020

cites work

1 reference

Strategies to improve plasma half life time of peptide and protein drugs

21 January 2018

1 reference

21 January 2018

1 reference

GnRH analogues: applications in assisted reproductive techniques

21 January 2018

1 reference

Opportunities in somatostatin research: biological, chemical and therapeutic aspects

21 January 2018

1 reference

The choice of a tocolytic for the treatment of preterm labor: a critical evaluation of nifedipine versus atosiban

21 January 2018

1 reference

Desmopressin 30 years in clinical use: a safety review

21 January 2018

1 reference

Current and emerging management options for hereditary angioedema in the US.

21 January 2018

1 reference

Pramlintide in the treatment of diabetes mellitus

21 January 2018

1 reference

Pharmacology of exenatide (synthetic exendin-4): a potential therapeutic for improved glycemic control of type 2 diabetes

21 January 2018

1 reference

Direct antithrombins: new perspectives in cardiovascular medicine

21 January 2018

1 reference

21 January 2018

Bivalirudin: a review

1 reference

Glycoprotein IIb/IIIa antagonists in acute ischaemic stroke: current status and future directions.

21 January 2018

1 reference

Recombinant omega-conotoxin MVIIA possesses strong analgesic activity.

21 January 2018

1 reference

N-Methylated cyclic RGD peptides as highly active and selective alpha(V)beta(3) integrin antagonists

21 January 2018

1 reference

Nanomolar small molecule inhibitors for alphav(beta)6, alphav(beta)5, and alphav(beta)3 integrins

21 January 2018

1 reference

Peptides with anticancer use or potential.

21 January 2018

1 reference

The cyclization of peptides and depsipeptides

21 January 2018

1 reference

Amide bond formation and peptide coupling

21 January 2018

1 reference

Amide bond formation: beyond the myth of coupling reagents

21 January 2018

1 reference

An activated O --> N acyl transfer auxiliary: efficient amide-backbone substitution of hindered "difficult" peptides.

21 January 2018

1 reference

Cyclic tetrapeptides via the ring contraction strategy: chemical techniques useful for their identification.

21 January 2018

1 reference

Controlled production of amyloid beta peptide from a photo-triggered, water-soluble precursor "click peptide".

21 January 2018

1 reference

Solid-phase peptide synthesis: from standard procedures to the synthesis of difficult sequences.

21 January 2018

1 reference

Application of the O-N intramolecular acyl migration reaction in medicinal chemistry

21 January 2018

1 reference

Switch-peptides as folding precursors in self-assembling peptides and amyloid fibrillogenesis

21 January 2018

1 reference

Synthesis of oxytocin analogues with replacement of sulfur by carbon gives potent antagonists with increased stability

21 January 2018

1 reference

Dicarba analogues of the cyclic enkephalin peptides H-Tyr-c[D-Cys-Gly-Phe-D(or L)-Cys]NH(2) retain high opioid activity

21 January 2018

1 reference

Synthesis of stable and potent delta/mu opioid peptides: analogues of H-Tyr-c[D-Cys-Gly-Phe-D-Cys]-OH by ring-closing metathesis

21 January 2018

1 reference

Synthesis and bio-assay of RCM-derived Bowman-Birk inhibitor analogues

21 January 2018

1 reference

Synthesis of bicyclic alkene-/alkane-bridged nisin mimics by ring-closing metathesis and their biochemical evaluation as lipid II binders: toward the design of potential novel antibiotics.

21 January 2018

1 reference

Designing peptide receptor agonists and antagonists

21 January 2018

1 reference

Reversible backbone protection enables combinatorial solid-phase ring-closing metathesis reaction (RCM) in peptides.

21 January 2018

1 reference

Solid phase synthesis and structural analysis of novel A-chain dicarba analogs of human relaxin-3 (INSL7) that exhibit full biological activity

21 January 2018

1 reference

Peptidomimetics via copper-catalyzed azide-alkyne cycloadditions.

21 January 2018

1 reference

Synthesis and conformational analysis of a cyclic peptide obtained via i to i+4 intramolecular side-chain to side-chain azide-alkyne 1,3-dipolar cycloaddition

21 January 2018

1 reference

Side chain-to-side chain cyclization by click reaction

21 January 2018

1 reference

Head-to-tail peptide cyclodimerization by copper-catalyzed azide-alkyne cycloaddition

21 January 2018

1 reference

Efficient route to C2 symmetric heterocyclic backbone modified cyclic peptides

21 January 2018

1 reference

Click chemistry as a macrocyclization tool in the solid-phase synthesis of small cyclic peptides.

21 January 2018

1 reference

Copper(I)-catalyzed synthesis of azoles. DFT study predicts unprecedented reactivity and intermediates

21 January 2018

1 reference

Probing the bioactive conformation of an archetypal natural product HDAC inhibitor with conformationally homogeneous triazole-modified cyclic tetrapeptides.

21 January 2018

1 reference

Conformationally homogeneous heterocyclic pseudotetrapeptides as three-dimensional scaffolds for rational drug design: receptor-selective somatostatin analogues

21 January 2018

1 reference

The Staudinger ligation-a gift to chemical biology.

21 January 2018

1 reference

Staudinger ligation: a peptide from a thioester and azide.

21 January 2018

1 reference

A "traceless" Staudinger ligation for the chemoselective synthesis of amide bonds

21 January 2018

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Staudinger ligation of peptides at non-glycyl residues

21 January 2018

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Reaction mechanism and kinetics of the traceless Staudinger ligation

21 January 2018

1 reference

Convergent glycopeptide synthesis by traceless Staudinger ligation and enzymatic coupling

21 January 2018

1 reference

Water-soluble phosphinothiols for traceless staudinger ligation and integration with expressed protein ligation

21 January 2018

1 reference

Electronic and steric effects on the rate of the traceless Staudinger ligation

21 January 2018

1 reference

Development of a functional backbone cyclic mimetic of the HIV-1 Tat arginine-rich motif

21 January 2018

1 reference

Effect of structural and conformation modifications, including backbone cyclization, of hydrophilic hexapeptides on their intestinal permeability and enzymatic stability

21 January 2018

1 reference

Human somatostatin receptor specificity of backbone-cyclic analogues containing novel sulfur building units

21 January 2018

1 reference

Insect neuropeptide antagonist. Part II. Synthesis and biological activity of backbone cyclic and precyclic PBAN antagonists

21 January 2018

1 reference

Synthesis of a novel macrocyclic library: discovery of an IGF-1R inhibitor

21 January 2018

1 reference

Design and synthesis of potent and selective alpha(4)beta(7) integrin antagonists

21 January 2018

1 reference

Integrins: molecular targets in cancer therapy

21 January 2018

1 reference

Peptide design using alpha,beta-dehydro amino acids: from beta-turns to helical hairpins

21 January 2018

1 reference

Control of peptide conformation by the Thorpe-Ingold effect (C alpha-tetrasubstitution).

21 January 2018

1 reference

Expanding the polypeptide backbone: hydrogen-bonded conformations in hybrid polypeptides containing the higher homologues of alpha-amino acids

21 January 2018

1 reference

The constrained amino acid beta-Acc confers potency and selectivity to integrin ligands

21 January 2018

1 reference

Recent progress of the synthetic studies of biologically active marine cyclic peptides and depsipeptides

21 January 2018

1 reference

Rapid optimization of a peptide inhibitor of malaria parasite invasion by comprehensive N-methyl scanning

21 January 2018

1 reference

Diketopiperazines as a tool for the study of transport across the blood-brain barrier (BBB) and their potential use as BBB-shuttles

21 January 2018

1 reference

Main chain hydrogen bond interactions in the binding of proline-rich gluten peptides to the celiac disease-associated HLA-DQ2 molecule.

21 January 2018

1 reference

N- and Calpha-methylation in biologically active peptides: synthesis, structural and functional aspects.

21 January 2018

1 reference

Structure-activity relationship and metabolic stability studies of backbone cyclization and N-methylation of melanocortin peptides

21 January 2018

1 reference

N-Methyl scan of somatostatin octapeptide agonists produces interesting effects on receptor subtype specificity

21 January 2018

1 reference

Highly potent and subtype selective ligands derived by N-methyl scan of a somatostatin antagonist.

21 January 2018

1 reference

Multiple N-methylation by a designed approach enhances receptor selectivity

21 January 2018

1 reference

Solid-phase synthesis and characterization of N-methyl-rich peptides.

21 January 2018

1 reference

Efficient, racemization-free peptide coupling of N-alkyl amino acids by using amino acid chlorides generated in situ--total syntheses of the cyclopeptides cyclosporin O and omphalotin A.

21 January 2018

1 reference

Convenient synthesis of N-methylamino acids compatible with Fmoc solid-phase peptide synthesis

21 January 2018

1 reference

Optimized selective N-methylation of peptides on solid support

21 January 2018

1 reference

N-methylated cyclic pentaalanine peptides as template structures

21 January 2018

1 reference

Conformational preference and potential templates of N-methylated cyclic pentaalanine peptides

21 January 2018

1 reference

N-methylation of peptides: a new perspective in medicinal chemistry

21 January 2018

1 reference

NMe amide as a synthetic surrogate for the thioester moiety in thiocoraline

21 January 2018

1 reference

Application of Ring-Closing Metathesis to the Synthesis of Rigidified Amino Acids and Peptides

21 January 2018

1 reference

β-Amino acid-containing hybrid peptides—new opportunities in peptidomimetics

21 January 2018

1 reference

Difficult Macrocyclizations: New Strategies for Synthesizing Highly Strained Cyclic Tetrapeptides

21 January 2018

1 reference

Synthesis of cyclic peptides via O–N-acyl migration

21 January 2018

1 reference

1,2,3-Triazoles as peptide bond isosteres: synthesis and biological evaluation of cyclotetrapeptide mimics

21 January 2018

1 reference

Improving Oral Bioavailability of Peptides by Multiple N-Methylation: Somatostatin Analogues

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.4155/FMC.09.97

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21426104%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

1 reference