(Q33852488)

29 July 2017

title

Microwave-assisted synthesis of a pyrazolyl ketone library for evaluation as p38 MAPK inhibitors in Werner syndrome cells (English)

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29 July 2017

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Mark C Bagley

1

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29 July 2017

Terence Davis

2

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29 July 2017

Matthew C Dix

3

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29 July 2017

Paola Gs Murziani

4

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29 July 2017

Michal J Rokicki

5

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29 July 2017

David Kipling

6

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29 July 2017

publication date

1 February 2010

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Future Medicinal Chemistry

29 July 2017

published in

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29 July 2017

volume

2

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29 July 2017

issue

2

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29 July 2017

page(s)

203-213

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What geriatricians should know about the Werner syndrome

29 July 2017

cites work

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https://api.crossref.org/works/10.4155%2FFMC.09.160

Positional cloning of the Werner's syndrome gene

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What can progeroid syndromes tell us about human aging?

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Werner and Hutchinson-Gilford progeria syndromes: mechanistic basis of human progeroid diseases.

21 January 2018

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Replicative senescence: an old lives' tale?

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How might replicative senescence contribute to human ageing?

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.09.160

Prevention of accelerated cell aging in Werner syndrome using a p38 mitogen-activated protein kinase inhibitor.

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.09.160

Prevention of accelerated cell aging in the Werner syndrome

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.09.160

The role of cellular senescence in Werner syndrome: toward therapeutic intervention in human premature aging

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.09.160

Normal telomere erosion rates at the single cell level in Werner syndrome fibroblast cells.

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.09.160

Werner Syndrome as an example of inflamm-aging: possible therapeutic opportunities for a progeroid syndrome?

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.160

Microwave-assisted synthesis of N-pyrazole ureas and the p38alpha inhibitor BIRB 796 for study into accelerated cell ageing

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.09.160

Rapid synthesis of VX-745: p38 MAP kinase inhibition in Werner syndrome cells.

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.09.160

Microwave-assisted Ullmann C-S bond formation: synthesis of the P38alpha MAPK clinical candidate VX-745.

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.09.160

Synthesis of the highly selective p38 MAPK inhibitor UR-13756 for possible therapeutic use in Werner syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.160

Microwave-assisted synthesis of 5-aminopyrazol-4-yl ketones and the p38(MAPK) inhibitor RO3201195 for study in Werner syndrome cells

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.160

Microwave dielectric heating in synthetic organic chemistry

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.09.160

Microwave energy: a versatile tool for the biosciences

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.09.160

The impact of microwave synthesis on drug discovery.

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.09.160

Controlled microwave heating in modern organic synthesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.160

Discovery of S-[5-amino-1-(4-fluorophenyl)-1H-pyrazol-4-yl]-[3-(2,3-dihydroxypropoxy)phenyl]methanone (RO3201195), an orally bioavailable and highly selective inhibitor of p38 MAP kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.160

Elimination of protein kinase MK5/PRAK activity by targeted homologous recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.160

Unlocking the chemotherapeutic potential of beta-aminovinyl ketones and related compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.160

21 January 2018

Identifiers

DOI

10.4155/FMC.09.160

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29 July 2017

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