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Pharmacological manipulations of CNS sirtuins: potential effects on metabolic homeostasis.
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Europe PubMed Central
PMC publication ID
2871985
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20138996%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 January 2020
review article
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stated in
Europe PubMed Central
title
Pharmacological manipulations of CNS sirtuins: potential effects on metabolic homeostasis
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
2871985
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20138996%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 January 2020
author
Giorgio Ramadori
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMC publication ID
2871985
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20138996%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 January 2020
author name string
Roberto Coppari
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMC publication ID
2871985
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20138996%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 January 2020
publication date
6 February 2010
1 reference
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Europe PubMed Central
PMC publication ID
2871985
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20138996%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 January 2020
published in
Pharmacological Research
1 reference
stated in
Europe PubMed Central
PMC publication ID
2871985
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20138996%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 January 2020
volume
62
1 reference
stated in
Europe PubMed Central
PMC publication ID
2871985
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20138996%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 January 2020
issue
1
1 reference
stated in
Europe PubMed Central
PMC publication ID
2871985
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20138996%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 January 2020
page(s)
48-54
1 reference
stated in
Europe PubMed Central
PMC publication ID
2871985
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20138996%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 January 2020
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Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha
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5 July 2018
Genomic instability and aging-like phenotype in the absence of mammalian SIRT6
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5 July 2018
Identifying hypothalamic pathways controlling food intake, body weight, and glucose homeostasis
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Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins
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5 July 2018
Obesity and metabolic syndrome in circadian Clock mutant mice
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5 July 2018
Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase
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Mechanism of human SIRT1 activation by resveratrol
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Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1
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5 July 2018
Calorie restriction--the SIR2 connection
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871985
retrieved
5 July 2018
Substrate-specific activation of sirtuins by resveratrol
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871985
retrieved
5 July 2018
SIRT3, a mitochondrial sirtuin deacetylase, regulates mitochondrial function and thermogenesis in brown adipocytes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871985
retrieved
5 July 2018
Accumulation of free ADP-ribose from mitochondria mediates oxidative stress-induced gating of TRPM2 cation channels
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871985
retrieved
5 July 2018
Distinct pathways of insulin-regulated versus diabetes-regulated gene expression: an in vivo analysis in MIRKO mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871985
retrieved
5 July 2018
Sir2 mediates longevity in the fly through a pathway related to calorie restriction
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871985
retrieved
5 July 2018
An accelerated assay for the identification of lifespan-extending interventions in Drosophila melanogaster
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871985
retrieved
5 July 2018
Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871985
retrieved
5 July 2018
Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871985
retrieved
5 July 2018
Sirtuin activators mimic caloric restriction and delay ageing in metazoans
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871985
retrieved
5 July 2018
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871985
retrieved
5 July 2018
Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871985
retrieved
5 July 2018
Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871985
retrieved
5 July 2018
Mammalian SIRT1 represses forkhead transcription factors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871985
retrieved
5 July 2018
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871985
retrieved
5 July 2018
The retardation of aging by caloric restriction: its significance in the transgenic era.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871985
retrieved
5 July 2018
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871985
retrieved
5 July 2018
Minireview: lipid metabolism, metabolic diseases, and peroxisome proliferator-activated receptors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871985
retrieved
5 July 2018
Regulation of hepatic fasting response by PPARgamma coactivator-1alpha (PGC-1): requirement for hepatocyte nuclear factor 4alpha in gluconeogenesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871985
retrieved
5 July 2018
The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871985
retrieved
5 July 2018
How does calorie restriction work?
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871985
retrieved
5 July 2018
The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871985
retrieved
5 July 2018
Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871985
retrieved
5 July 2018
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871985
retrieved
5 July 2018
Obesity and the regulation of energy balance
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871985
retrieved
5 July 2018
A cytosolic NAD-dependent deacetylase, Hst2p, can modulate nucleolar and telomeric silencing in yeast
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871985
retrieved
5 July 2018
Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871985
retrieved
5 July 2018
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871985
retrieved
5 July 2018
The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871985
retrieved
5 July 2018
Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871985
retrieved
5 July 2018
The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871985
retrieved
5 July 2018
Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871985
retrieved
29 October 2018
SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871985
retrieved
29 October 2018
Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871985
retrieved
29 October 2018
Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871985
retrieved
29 October 2018
Divergence of melanocortin pathways in the control of food intake and energy expenditure.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871985
retrieved
29 October 2018
A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871985
retrieved
29 October 2018
SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871985
retrieved
29 October 2018
Nutritional regulation of hepatic heme biosynthesis and porphyria through PGC-1alpha
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871985
retrieved
29 October 2018
Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871985
retrieved
29 October 2018
The hypothalamic arcuate nucleus: a key site for mediating leptin's effects on glucose homeostasis and locomotor activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871985
retrieved
29 October 2018
Hypothalamic sensing of circulating fatty acids is required for glucose homeostasis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871985
retrieved
29 October 2018
Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871985
retrieved
29 October 2018
Nutrient availability regulates SIRT1 through a forkhead-dependent pathway.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871985
retrieved
29 October 2018
Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871985
retrieved
29 October 2018
Longevity regulation by Drosophila Rpd3 deacetylase and caloric restriction.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871985
retrieved
29 October 2018
Constitutive nuclear factor-kappa B activity is required for central neuron survival.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871985
retrieved
29 October 2018
Increase in activity during calorie restriction requires Sirt1
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/20138996
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Partnership of PGC-1alpha and HNF4alpha in the regulation of lipoprotein metabolism
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/20138996
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Metabolite of SIR2 reaction modulates TRPM2 ion channel
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/20138996
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1016/J.PHRS.2010.02.002
1 reference
stated in
Europe PubMed Central
PMC publication ID
2871985
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20138996%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 January 2020
PMC publication ID
2871985
1 reference
stated in
Europe PubMed Central
PMC publication ID
2871985
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20138996%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 January 2020
PubMed publication ID
20138996
1 reference
stated in
Europe PubMed Central
PMC publication ID
2871985
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20138996%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 January 2020
ResearchGate publication ID
41413509
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