(Q33858600)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24977291%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

title

Factor VIIa binding to endothelial cell protein C receptor protects vascular barrier integrity in vivo (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24977291%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

0 references

Ramakrishnan Gopalakrishnan

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24977291%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

author name string

J Sundaram

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24977291%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

S Keshava

2

1 reference

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21 March 2020

C T Esmon

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24977291%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

U R Pendurthi

5

1 reference

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21 March 2020

L V M Rao

6

1 reference

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21 March 2020

publication date

1 May 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24977291%20AND%20SRC:MED&resulttype=core&format=json

Journal of Thrombosis and Haemostasis

21 March 2020

published in

1 reference

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21 March 2020

volume

12

1 reference

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21 March 2020

issue

5

1 reference

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21 March 2020

page(s)

690-700

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24977291%20AND%20SRC:MED&resulttype=core&format=json

Novel mechanisms for activated protein C cytoprotective activities involving noncanonical activation of protease-activated receptor 3.

21 March 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085578

Biased agonism of protease-activated receptor 1 by activated protein C caused by noncanonical cleavage at Arg46.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085578

Systematic review: benefits and harms of in-hospital use of recombinant factor VIIa for off-label indications

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085578

Recombinant factor VIIa: an assessment of evidence regarding its efficacy and safety in the off-label setting

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085578

Factor X/Xa elicits protective signaling responses in endothelial cells directly via PAR-2 and indirectly via endothelial protein C receptor-dependent recruitment of PAR-1

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085578

Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085578

The ligand occupancy of endothelial protein C receptor switches the protease-activated receptor 1-dependent signaling specificity of thrombin from a permeability-enhancing to a barrier-protective response in endothelial cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085578

Protease-activated receptor 1-selective antagonist SCH79797 inhibits cell proliferation and induces apoptosis by a protease-activated receptor 1-independent mechanism

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085578

Multifunctional specificity of the protein C/activated protein C Gla domain.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085578

Extraembryonic expression of EPCR is essential for embryonic viability

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085578

Endothelial barrier protection by activated protein C through PAR1-dependent sphingosine 1-phosphate receptor-1 crossactivation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085578

Activation of endothelial cell protease activated receptor 1 by the protein C pathway

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085578

Mechanisms regulating endothelial cell barrier function

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085578

Vascular endothelial-cadherin is an important determinant of microvascular integrity in vivo

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085578

Increased capillary permeability in haemophilia and afibrinogenaemia

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085578

Endothelial cell protein C receptor acts as a cellular receptor for factor VIIa on endothelium

28 July 2018

1 reference

Endothelial cell protein C receptor cellular localization and trafficking: potential functional implications

21 January 2018

1 reference

Binding of factor VIIa to the endothelial cell protein C receptor reduces its coagulant activity.

21 January 2018

1 reference

Factor VIIa bound to endothelial cell protein C receptor activates protease activated receptor-1 and mediates cell signaling and barrier protection

21 January 2018

1 reference

Coagulation factor Xa cleaves protease-activated receptor-1 and mediates signaling dependent on binding to the endothelial protein C receptor.

21 January 2018

1 reference

Endothelial cell protein C receptor-mediated redistribution and tissue-level accumulation of factor VIIa

21 January 2018

1 reference

Overexpressing endothelial cell protein C receptor alters the hemostatic balance and protects mice from endotoxin.

21 January 2018

1 reference

Concentration dependent dual effect of thrombin in endothelial cells via Par-1 and Pi3 Kinase

21 January 2018

1 reference

Organ-specific protection against lipopolysaccharide-induced vascular leak is dependent on the endothelial protein C receptor.

21 January 2018

1 reference

Broken barriers: a new take on sepsis pathogenesis.

21 January 2018

1 reference

Low-dose recombinant factor VIIa for trauma patients with coagulopathy

21 January 2018

1 reference

Protection of vascular barrier integrity by activated protein C in murine models depends on protease-activated receptor-1.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085578

Factor VIIa and its potential therapeutic use in bleeding-associated pathologies.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085578

Haemophilia, AIDS and lung epithelial permeability.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085578

Plasma elimination kinetics for factor VII are independent of its activation to factor VIIa and complex formation with plasma inhibitors

29 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24977291

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Gastric bleeding and increased gastric vascular permeability induced by platelet activating factor (PAF): effect of drugs that affect arachidonate metabolism

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24977291

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1111/JTH.12532

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24977291%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24977291%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

1 reference