(Q36360425)

English

The ligand occupancy of endothelial protein C receptor switches the protease-activated receptor 1-dependent signaling specificity of thrombin from a permeability-enhancing to a barrier-protective response in endothelial cells

scientific article

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scholarly article

1 reference

Europe PubMed Central

13 August 2017

The ligand occupancy of endothelial protein C receptor switches the protease-activated receptor 1-dependent signaling specificity of thrombin from a permeability-enhancing to a barrier-protective response in endothelial cells (English)

1 reference

Europe PubMed Central

13 August 2017

0 references

author name string

Jong-Sup Bae

1

1 reference

Europe PubMed Central

13 August 2017

Likui Yang

2

1 reference

Europe PubMed Central

13 August 2017

Chandrashekhara Manithody

3

1 reference

Europe PubMed Central

13 August 2017

Alireza R Rezaie

4

1 reference

Europe PubMed Central

13 August 2017

language of work or name

0 references

publication date

6 September 2007

1 reference

Europe PubMed Central

13 August 2017

1 reference

Europe PubMed Central

13 August 2017

110

1 reference

Europe PubMed Central

13 August 2017

12

1 reference

Europe PubMed Central

13 August 2017

3909-3916

1 reference

Europe PubMed Central

13 August 2017

Endothelial cell protein C receptor acts as a cellular receptor for factor VIIa on endothelium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190610

30 September 2017

Receptors of the protein C activation and activated protein C signaling pathways are colocalized in lipid rafts of endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190610

30 September 2017

Engineering a disulfide bond to stabilize the calcium-binding loop of activated protein C eliminates its anticoagulant but not its protective signaling properties

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190610

30 September 2017

Protective signaling by activated protein C is mechanistically linked to protein C activation on endothelial cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190610

30 September 2017

Protease-activated receptors-1 and -2 can mediate endothelial barrier protection: role in factor Xa signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190610

30 September 2017

Endothelial barrier protection by activated protein C through PAR1-dependent sphingosine 1-phosphate receptor-1 crossactivation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190610

30 September 2017

Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190610

30 September 2017

Zymogenic and enzymatic properties of the 70-80 loop mutants of factor X/Xa

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190610

30 September 2017

Specificity of coagulation factor signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190610

30 September 2017

Inhibition of staurosporine-induced apoptosis of endothelial cells by activated protein C requires protease-activated receptor-1 and endothelial cell protein C receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190610

30 September 2017

Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190610

30 September 2017

Activation of endothelial cell protease activated receptor 1 by the protein C pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190610

30 September 2017

Contribution of basic residues of the 70-80-loop to heparin binding and anticoagulant function of activated protein C.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190610

30 September 2017

G alpha minigenes expressing C-terminal peptides serve as specific inhibitors of thrombin-mediated endothelial activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190610

30 September 2017

Efficacy and safety of recombinant human activated protein C for severe sepsis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190610

30 September 2017

Reactivities of the S2 and S3 subsite residues of thrombin with the native and heparin-induced conformers of antithrombin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190610

30 September 2017

Deficiency of protein C in congenital thrombotic disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190610

30 September 2017

Structure and function of protein C.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190610

30 September 2017

The refined 1.9 A crystal structure of human alpha-thrombin: interaction with D-Phe-Pro-Arg chloromethylketone and significance of the Tyr-Pro-Pro-Trp insertion segment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190610

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190610

30 September 2017

Regulation of blood coagulation by the protein C system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190610

30 September 2017

Cytokine upregulation of proteinase-activated-receptors 2 and 4 expression mediated by p38 MAP kinase and inhibitory kappa B kinase beta in human endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190610

28 June 2018

Multifunctional specificity of the protein C/activated protein C Gla domain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190610

28 June 2018

Thrombin receptor-activating peptides differentially stimulate platelet-derived growth factor production, monocytic cell adhesion, and E-selectin expression in human umbilical vein endothelial cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190610

28 June 2018

Protein S and C4b-binding protein: components involved in the regulation of the protein C anticoagulant system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190610

28 June 2018

Is APC activation of endothelial cell PAR1 important in severe sepsis?: No.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190610

22 September 2018

Functional selectivity of G protein signaling by agonist peptides and thrombin for the protease-activated receptor-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190610

22 September 2018

Activated protein C mediates novel lung endothelial barrier enhancement: role of sphingosine 1-phosphate receptor transactivation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190610

22 September 2018

PAR1 cleavage and signaling in response to activated protein C and thrombin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190610

22 September 2018

Anti-inflammatory, antithrombotic, and neuroprotective effects of activated protein C in a murine model of focal ischemic stroke.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190610

22 September 2018

Gene expression profile of antithrombotic protein c defines new mechanisms modulating inflammation and apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190610

22 September 2018

Is APC activation of endothelial cell PAR1 important in severe sepsis?: Yes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17823308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct Vascular Effects of Protease-Activated Receptor Type 1 Agonism In Vivo in Humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/17823308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of exosites 1 and 2 in thrombin reaction with plasminogen activator inhibitor-1 in the absence and presence of cofactors

1 reference

https://pubmed.ncbi.nlm.nih.gov/17823308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The endothelial cell protein C receptor aids in host defense against Escherichia coli sepsis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17823308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple active forms of thrombin. IV. Relative activities of meizothrombins

1 reference

https://pubmed.ncbi.nlm.nih.gov/17823308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular events that control the protein C anticoagulant pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/17823308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Compartmentalization of phosphatidylinositol 4,5-bisphosphate in low-density membrane domains in the absence of caveolin

1 reference

https://pubmed.ncbi.nlm.nih.gov/17823308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1182/BLOOD-2007-06-096651

1 reference

Europe PubMed Central

13 August 2017

1 reference

Europe PubMed Central

13 August 2017

1 reference

Europe PubMed Central

13 August 2017

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0 references

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