(Q33859100)

29 July 2017

title

DNA breaks and chromosomal aberrations arise when replication meets base excision repair (English)

1 reference

29 July 2017

Michael Ensminger

1

1 reference

29 July 2017

Lucie Iloff

2

1 reference

29 July 2017

Christian Ebel

3

1 reference

29 July 2017

Teodora Nikolova

4

1 reference

29 July 2017

Bernd Kaina

5

1 reference

29 July 2017

Markus Lӧbrich

6

1 reference

29 July 2017

language of work or name

English

0 references

publication date

30 June 2014

1 reference

29 July 2017

number of pages

15

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inferred from page(s)

published in

Journal of Cell Biology

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29 July 2017

volume

206

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29 July 2017

issue

1

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29 July 2017

page(s)

29-43

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describes a project that uses

29 July 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4085701/fullTextXML

inferred from PubMed Central ID database lookup

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Co-ordination of base excision repair and genome stability

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Alkylation base damage is converted into repairable double-strand breaks and complex intermediates in G2 cells lacking AP endonuclease.

5 July 2018

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5 July 2018

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5 July 2018

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Hydroxyurea-stalled replication forks become progressively inactivated and require two different RAD51-mediated pathways for restart and repair.

5 July 2018

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5 July 2018

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Aag-initiated base excision repair drives alkylation-induced retinal degeneration in mice

5 July 2018

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Chk2-dependent phosphorylation of XRCC1 in the DNA damage response promotes base excision repair

5 July 2018

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5 July 2018

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The methyl methanesulfonate induced S-phase delay in XRCC1-deficient cells requires ATM and ATR.

5 July 2018

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XRCC1 and DNA polymerase beta in cellular protection against cytotoxic DNA single-strand breaks

5 July 2018

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Methylating agents and DNA repair responses: Methylated bases and sources of strand breaks

5 July 2018

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Replisome assembly and the direct restart of stalled replication forks

5 July 2018

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DNA damage evaluated by gammaH2AX foci formation by a selective group of chemical/physical stressors

5 July 2018

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Spontaneous homologous recombination is induced by collapsed replication forks that are caused by endogenous DNA single-strand breaks

5 July 2018

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The accumulation of MMS-induced single strand breaks in G1 phase is recombinogenic in DNA polymerase beta defective mammalian cells

5 July 2018

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5 July 2018

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5 July 2018

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XRCC1 and DNA strand break repair

5 July 2018

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Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085701

A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome

5 July 2018

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Intrachanges as part of complex chromosome-type exchange aberrations.

5 July 2018

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XRCC1 coordinates the initial and late stages of DNA abasic site repair through protein-protein interactions

5 July 2018

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Characterization of homologous recombination induced by replication inhibition in mammalian cells

5 July 2018

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XRCC1 stimulates human polynucleotide kinase activity at damaged DNA termini and accelerates DNA single-strand break repair

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085701

Conversion of topoisomerase I cleavage complexes on the leading strand of ribosomal DNA into 5'-phosphorylated DNA double-strand breaks by replication runoff

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085701

Pharmacologic disruption of base excision repair sensitizes mismatch repair-deficient and -proficient colon cancer cells to methylating agents

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085701

Alkylpurine-DNA-N-glycosylase knockout mice show increased susceptibility to induction of mutations by methyl methanesulfonate

5 July 2018

1 reference

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Elements in abasic site recognition by the major human and Escherichia coli apurinic/apyrimidinic endonucleases

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085701

DNA repair defect in poly(ADP-ribose) polymerase-deficient cell lines

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085701

XRCC1 is specifically associated with poly(ADP-ribose) polymerase and negatively regulates its activity following DNA damage

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085701

A chemical and genetic approach together define the biological consequences of 3-methyladenine lesions in the mammalian genome

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085701

Mutations in hamster single-strand break repair gene XRCC1 causing defective DNA repair

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085701

Interaction of human apurinic endonuclease and DNA polymerase beta in the base excision repair pathway

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085701

XRCC1 polypeptide interacts with DNA polymerase beta and possibly poly (ADP-ribose) polymerase, and DNA ligase III is a novel molecular 'nick-sensor' in vitro

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085701

Requirement of mammalian DNA polymerase-beta in base-excision repair.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085701

Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085701

A CHO-cell strain having hypersensitivity to mutagens, a defect in DNA strand-break repair, and an extraordinary baseline frequency of sister-chromatid exchange

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085701

Mechanisms of chromosomal aberration production. 3. Chemicals and ionizing radiation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085701

Incorporated bromodeoxyuridine enhances the sister-chromatid exchange and chromosomal aberration frequencies in an EMS-sensitive Chinese hamster cell line

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085701

Negative regulatory element associated with potentially functional promoter and enhancer elements in the long terminal repeats of endogenous murine leukemia virus-related proviral sequences.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085701

Distribution of methyl and ethyl adducts following alkylation with monofunctional alkylating agents

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085701

Cloning and expression in Escherichia coli of a human cDNA encoding the DNA repair protein N-methylpurine-DNA glycosylase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085701

A Chinese hamster ovary cell mutant (EM-C11) with sensitivity to simple alkylating agents and a very high level of sister chromatid exchanges

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085701

Mutagen specificity in the induction of chromosomal aberrations in somatic cells of Drosophila melanogaster

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085701

Chromosome damage in the bone marrow of mice treated with the methylating agents methyl methanesulphonate and N-methyl-N-nitrosourea in the presence or absence of caffeine, and its relationship with thymoma induction

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085701

Methylated DNA causes a physical block to replication forks independently of damage signalling, O(6)-methylguanine or DNA single-strand breaks and results in DNA damage.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085701

The structure-specific endonuclease Mus81 contributes to replication restart by generating double-strand DNA breaks

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085701

Study of interaction of XRCC1 with DNA and proteins of base excision repair by photoaffinity labeling technique.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085701

XRCC1 interactions with multiple DNA glycosylases: a model for its recruitment to base excision repair.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085701

Methoxyamine potentiates DNA single strand breaks and double strand breaks induced by temozolomide in colon cancer cells

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085701

Nuclear retention of ATM at sites of DNA double strand breaks

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085701

Mammalian abasic site base excision repair. Identification of the reaction sequence and rate-determining steps

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085701

Overexpression of human DNA repair protein N-methylpurine-DNA glycosylase results in the increased removal of N-methylpurines in DNA without a concomitant increase in resistance to alkylating agents in Chinese hamster ovary cells

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085701

The induction of chromosome aberrations by nitrogen mustard and its dependence on DNA synthesis

29 October 2018

1 reference

12 December 2020

Induction of sister-chromatid exchanges (SCEs) and chromosomal aberrations by mitomycin C and methyl methanesulfonate in Chinese hamster ovary cells. An evaluation of methodology for detection of SCEs and of persistent DNA lesions towards the freque

1 reference

12 December 2020

Molecular mechanisms involved in the production of chromosomal aberrations. III. Restriction endonucleases

1 reference

12 December 2020

Methylation-induced blocks to in vitro DNA replication

1 reference

12 December 2020

Induction of sister-chromatid exchanges by restriction endonucleases

1 reference

12 December 2020

Changes of deoxyribonucleoside triphosphate pools induced by hydroxyurea and their relation to DNA synthesis

1 reference

12 December 2020

Overexpression of N-methylpurine-DNA glycosylase in Chinese hamster ovary cells renders them more sensitive to the production of chromosomal aberrations by methylating agents--a case of imbalanced DNA repair

1 reference

12 December 2020

Critical steps in alkylation-induced aberration formation

1 reference

12 December 2020

Single cell gel electrophoresis: detection of DNA damage at different levels of sensitivity

1 reference

12 December 2020

Identifiers

DOI

10.1083/JCB.201312078

1 reference

29 July 2017

1 reference

29 July 2017

1 reference