(Q33963811)

English

Conversion of topoisomerase I cleavage complexes on the leading strand of ribosomal DNA into 5'-phosphorylated DNA double-strand breaks by replication runoff

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scholarly article

1 reference

Europe PubMed Central

30 July 2017

Conversion of topoisomerase I cleavage complexes on the leading strand of ribosomal DNA into 5'-phosphorylated DNA double-strand breaks by replication runoff (English)

1 reference

Europe PubMed Central

30 July 2017

phosphorylation

0 references

author name string

D Strumberg

1

1 reference

Europe PubMed Central

30 July 2017

A A Pilon

2

1 reference

Europe PubMed Central

30 July 2017

M Smith

3

1 reference

Europe PubMed Central

30 July 2017

R Hickey

4

1 reference

Europe PubMed Central

30 July 2017

L Malkas

5

1 reference

Europe PubMed Central

30 July 2017

Y Pommier

6

1 reference

Europe PubMed Central

30 July 2017

language of work or name

0 references

publication date

1 June 2000

1 reference

Europe PubMed Central

30 July 2017

Molecular and Cellular Biology

1 reference

Europe PubMed Central

30 July 2017

20

1 reference

Europe PubMed Central

30 July 2017

3977-3987

1 reference

Europe PubMed Central

30 July 2017

11

1 reference

Europe PubMed Central

30 July 2017

Benzo[a]pyrene diol epoxide adducts in DNA are potent suppressors of a normal topoisomerase I cleavage site and powerful inducers of other topoisomerase I cleavages

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85758

5 July 2018

Induction of topoisomerase I cleavage complexes by 1-beta -D-arabinofuranosylcytosine (ara-C) in vitro and in ara-C-treated cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85758

5 July 2018

Yeast gene for a Tyr-DNA phosphodiesterase that repairs topoisomerase I complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85758

5 July 2018

Poisoning of human DNA topoisomerase I by ecteinascidin 743, an anticancer drug that selectively alkylates DNA in the minor groove

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85758

5 July 2018

Induction of reversible complexes between eukaryotic DNA topoisomerase I and DNA-containing oxidative base damages. 7, 8-dihydro-8-oxoguanine and 5-hydroxycytosine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85758

5 July 2018

Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85758

5 July 2018

Induction of topoisomerase I cleavage complexes by the vinyl chloride adduct 1,N6-ethenoadenine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85758

5 July 2018

On the mechanism of RecA-mediated repair of double-strand breaks: no role for four-strand DNA pairing intermediates.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85758

5 July 2018

Double-strand break repair mediated by DNA end-joining.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85758

5 July 2018

Mechanisms for the processing of a frozen topoisomerase-DNA conjugate by human cell-free extracts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85758

5 July 2018

A model for the mechanism of human topoisomerase I

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85758

5 July 2018

Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85758

5 July 2018

The involvement of topoisomerase I in the induction of DNA-protein crosslinks and DNA single-strand breaks in cells of ultraviolet-irradiated human and frog cell lines.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85758

5 July 2018

Processing of topoisomerase I cleavable complexes into DNA damage by transcription.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85758

5 July 2018

In vivo sequencing of camptothecin-induced topoisomerase I cleavage sites in human colon carcinoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85758

5 July 2018

Termination of mammalian rDNA replication: polar arrest of replication fork movement by transcription termination factor TTF-I.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85758

5 July 2018

Effects of uracil incorporation, DNA mismatches, and abasic sites on cleavage and religation activities of mammalian topoisomerase I.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85758

5 July 2018

Cell cycle-coupled relocation of types I and II topoisomerases and modulation of catalytic enzyme activities

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85758

5 July 2018

Repair of site-specific double-strand breaks in a mammalian chromosome by homologous and illegitimate recombination

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85758

5 July 2018

Double-strand break-induced mitotic intrachromosomal recombination in the fission yeast Schizosaccharomyces pombe

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85758

5 July 2018

DNA topoisomerases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85758

5 July 2018

A double-strand break within a yeast artificial chromosome (YAC) containing human DNA can result in YAC loss, deletion or cell lethality

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85758

5 July 2018

Differential replication of a single, UV-induced lesion in the leading or lagging strand by a human cell extract: fork uncoupling or gap formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85758

5 July 2018

Subcellular redistribution of DNA topoisomerase I in anaplastic astrocytoma cells treated with topotecan

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85758

5 July 2018

Conserved features in the mode of replication of eukaryotic ribosomal RNA genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85758

5 July 2018

Initiation and termination of DNA replication in human rRNA genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85758

5 July 2018

SV40 DNA replication intermediates: analysis of drugs which target mammalian DNA replication

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85758

5 July 2018

Eukaryotic DNA topoisomerases I.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85758

5 July 2018

Differential stabilization of eukaryotic DNA topoisomerase I cleavable complexes by camptothecin derivatives

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85758

5 July 2018

Cell cycle analysis of amount and distribution of nuclear DNA topoisomerase I as determined by fluorescence digital imaging microscopy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85758

5 July 2018

Mapping of replication initiation sites in human ribosomal DNA by nascent-strand abundance analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85758

5 July 2018

Hypersensitivity of Cockayne's syndrome cells to camptothecin is associated with the generation of abnormally high levels of double strand breaks in nascent DNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85758

5 July 2018

Complete sequence of the 43-kb human ribosomal DNA repeat: analysis of the intergenic spacer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85758

5 July 2018

International Commission for Protection Against Environmental Mutagens and Carcinogens. Mutagenicity and carcinogenicity of topoisomerase-interactive agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85758

5 July 2018

57 Sequencing end-labeled DNA with base-specific chemical cleavages

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85758

5 July 2018

Topoisomerase I interacts with transcribed regions in Drosophila cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85758

5 July 2018

Association of crossover points with topoisomerase I cleavage sites: a model for nonhomologous recombination

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85758

5 July 2018

Eukaryotic type I topoisomerase is enriched in the nucleolus and catalytically active on ribosomal DNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85758

5 July 2018

Camptothecin, a specific inhibitor of type I DNA topoisomerase, induces DNA breakage at replication forks

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85758

5 July 2018

Evidence that DNA topoisomerase I is necessary for the cytotoxic effects of camptothecin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85758

5 July 2018

Involvement of DNA topoisomerase I in transcription of human ribosomal RNA genes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85758

5 July 2018

Human ribosomal DNA: novel sequence organization in a 4.5-kb region upstream from the promoter

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85758

5 July 2018

The basis for camptothecin enhancement of DNA breakage by eukaryotic topoisomerase I.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85758

5 July 2018

Differential requirement of DNA replication for the cytotoxicity of DNA topoisomerase I and II inhibitors in Chinese hamster DC3F cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85758

5 July 2018

Protein-linked DNA strand breaks induced in mammalian cells by camptothecin, an inhibitor of topoisomerase I.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85758

5 July 2018

Exposure to camptothecin breaks leading and lagging strand simian virus 40 DNA replication forks

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85758

5 July 2018

Camptothecin cytotoxicity in mammalian cells is associated with the induction of persistent double strand breaks in replicating DNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85758

5 July 2018

Camptothecin-stabilized topoisomerase I-DNA adducts cause premature termination of transcription

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85758

5 July 2018

Two classes of DNA end-joining reactions catalyzed by vaccinia topoisomerase I.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85758

5 July 2018

Topoisomerase I inhibitors: selectivity and cellular resistance.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85758

29 October 2018

Mammalian DNA topoisomerase I activity and poisoning by camptothecin are inhibited by simian virus 40 large T antigen

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85758

29 October 2018

Mammalian topoisomerase I has base mismatch nicking activity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85758

29 October 2018

RNA synthesis inhibitors alter the subnuclear distribution of DNA topoisomerase I

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85758

29 October 2018

Minimal DNA duplex requirements for topoisomerase I-mediated cleavage in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85758

29 October 2018

Interaction between replication forks and topoisomerase I-DNA cleavable complexes: studies in a cell-free SV40 DNA replication system

1 reference

https://pubmed.ncbi.nlm.nih.gov/10805740

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA structural features that lead to strand breakage by eukaryotic type-I topoisomerase

1 reference

https://pubmed.ncbi.nlm.nih.gov/10805740

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I

1 reference

https://pubmed.ncbi.nlm.nih.gov/10805740

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sites of topoisomerase I action on X. laevis ribosomal chromatin: transcriptionally active rDNA has an approximately 200 bp repeating structure

1 reference

https://pubmed.ncbi.nlm.nih.gov/10805740

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ligation of nonmatching DNA molecule ends

1 reference

https://pubmed.ncbi.nlm.nih.gov/10805740

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Trapping of mammalian topoisomerase I and recombinations induced by damaged DNA containing nicks or gaps. Importance of DNA end phosphorylation and camptothecin effects

1 reference

https://pubmed.ncbi.nlm.nih.gov/10805740

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin

1 reference

https://pubmed.ncbi.nlm.nih.gov/10805740

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of action of camptothecin

1 reference

https://pubmed.ncbi.nlm.nih.gov/10805740

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential replication of a single N-2-acetylaminofluorene lesion in the leading or lagging strand DNA in a human cell extract

1 reference

https://pubmed.ncbi.nlm.nih.gov/10805740

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ultraviolet-induced DNA damage stimulates topoisomerase I-DNA complex formation in vivo: possible relationship with DNA repair

1 reference

https://pubmed.ncbi.nlm.nih.gov/10805740

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Investigating the biological functions of DNA topoisomerases in eukaryotic cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/10805740

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mapping the sites of initiation of DNA replication in rat and human rRNA genes

1 reference

https://pubmed.ncbi.nlm.nih.gov/10805740

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA recombinase activity of eukaryotic DNA topoisomerase I; effects of camptothecin and other inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/10805740

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Eukaryotic topoisomerase I-mediated cleavage requires bipartite DNA interaction. Cleavage of DNA substrates containing strand interruptions implicates a role for topoisomerase I in illegitimate recombination

1 reference

https://pubmed.ncbi.nlm.nih.gov/10805740

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of nucleic acid synthesis in cell killing mechanisms of topoisomerase poisons

1 reference

https://pubmed.ncbi.nlm.nih.gov/10805740

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relationship between cytotoxicity and site-specific DNA recombination after in vitro exposure of leukemia cells to etoposide

1 reference

https://pubmed.ncbi.nlm.nih.gov/10805740

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human DNA topoisomerase I-mediated cleavages stimulated by ultraviolet light-induced DNA damage

1 reference

https://pubmed.ncbi.nlm.nih.gov/10805740

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA strand transfer reactions catalyzed by vaccinia topoisomerase I

1 reference

https://pubmed.ncbi.nlm.nih.gov/10805740

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of action of eukaryotic DNA topoisomerase I and drugs targeted to the enzyme

1 reference

https://pubmed.ncbi.nlm.nih.gov/10805740

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/MCB.20.11.3977-3987.2000

1 reference

Europe PubMed Central

30 July 2017

1 reference

Europe PubMed Central

30 July 2017

1 reference

Europe PubMed Central

30 July 2017

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