(Q33861767)

29 July 2017

TC21 and Ras share indistinguishable transforming and differentiating activities (English)

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29 July 2017

Graham SM

1

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29 July 2017

Oldham SM

2

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29 July 2017

Martin CB

3

1 reference

29 July 2017

Drugan JK

4

1 reference

29 July 2017

Zohn IE

5

1 reference

29 July 2017

Campbell S

6

1 reference

29 July 2017

Der CJ

7

1 reference

29 July 2017

language of work or name

English

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publication date

1 March 1999

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29 July 2017

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29 July 2017

18

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29 July 2017

2107-2116

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29 July 2017

12

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1202517

29 July 2017

0 references

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

Proteins regulating Ras and its relatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

Structure and biological activity of human homologs of the raf/mil oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

The GTPase superfamily: conserved structure and molecular mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

Two distinct Raf domains mediate interaction with Ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

Activation of the cellular proto-oncogene product p21Ras by addition of a myristylation signal

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

A human oncogene of the RAS superfamily unmasked by expression cDNA cloning

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

Biological assays for Ras transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

14-3-3 zeta negatively regulates raf-1 activity by interactions with the Raf-1 cysteine-rich domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

p120 GAP modulates Ras activation of Jun kinases and transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

Activation of mitogen-activated protein kinase kinase by v-Raf in NIH 3T3 cells and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

Ras interaction with two distinct binding domains in Raf-1 may be required for Ras transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

Oncogenic Ha-Ras-induced signaling activates NF-kappaB transcriptional activity, which is required for cellular transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

Actions of Rho family small G proteins and p21-activated protein kinases on mitogen-activated protein kinase family members

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

Mouse beta-globin DNA-binding protein B1 is identical to a proto-oncogene, the transcription factor Spi-1/PU.1, and is restricted in expression to hematopoietic cells and the testis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

Aberrant function of the Ras-related protein TC21/R-Ras2 triggers malignant transformation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

TC21 causes transformation by Raf-independent signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

A human protein selected for interference with Ras function interacts directly with Ras and competes with Raf1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

Functional analysis of a growth factor-responsive transcription factor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

Transcriptional regulation by extracellular signals: mechanisms and specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

Activated Ras interacts with the Ral guanine nucleotide dissociation stimulator

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

Activation of the MAP kinase pathway by the protein kinase raf

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

Cysteine-rich region of Raf-1 interacts with activator domain of post-translationally modified Ha-Ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

R-Ras is regulated by activators and effectors distinct from those that control Ras function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

Activation of Rac1, RhoA, and mitogen-activated protein kinases is required for Ras transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

ralGDS family members interact with the effector loop of ras p21.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

Identification and characterization of R-ras3: a novel member of the RAS gene family with a non-ubiquitous pattern of tissue distribution

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

Raf-1 protein kinase is required for growth of induced NIH/3T3 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

Ras p21Val inhibits myogenesis without altering the DNA binding or transcriptional activities of the myogenic basic helix-loop-helix factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

Identification of AF-6 and canoe as putative targets for Ras.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

Raf-1 activates MAP kinase-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

The effector interactions of p21ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

Novel small GTPase M-Ras participates in reorganization of actin cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

Requirement of NF-kappaB activation to suppress p53-independent apoptosis induced by oncogenic Ras.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

Complexes of Ras.GTP with Raf-1 and mitogen-activated protein kinase kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

The complexity of Raf-1 regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

Activation of the Raf-1/MAP kinase cascade is not sufficient for Ras transformation of RIE-1 epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

The oncogenic forms of N-ras or H-ras prevent skeletal myoblast differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

Identification of a novel RalGDS-related protein as a candidate effector for Ras and Rap1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

Cdc42 regulates anchorage-independent growth and is necessary for Ras transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

An essential role for Rac in Ras transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

A role for Rho in Ras transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

Guanine nucleotide exchange factors: activators of the Ras superfamily of proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

Signaling through mitogen-activated protein kinase and Rac/Rho does not duplicate the effects of activated Ras on skeletal myogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

Biochemical Analysis of MEK Activation in NIH3T3 Fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

Phosphatidylinositol-3-OH kinase as a direct target of Ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

Direct interaction between Ras and the kinase domain of mitogen-activated protein kinase kinase kinase (MEKK1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

Definition of the human raf amino-terminal regulatory region by deletion mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

Activation of Raf as a result of recruitment to the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

rac1 regulates a cytokine-stimulated, redox-dependent pathway necessary for NF-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

Complex formation between RAS and RAF and other protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

Mammalian Ras interacts directly with the serine/threonine kinase Raf

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

R-Ras promotes apoptosis caused by growth factor deprivation via a Bcl-2 suppressible mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

Methods for analyzing c-Jun kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

Oncogenic Ras activates c-Jun via a separate pathway from the activation of extracellular signal-regulated kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

Rac regulation of transformation, gene expression, and actin organization by multiple, PAK-independent pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

Multiple Ras functions can contribute to mammalian cell transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

The cytoplasmic raf oncogene induces a neuronal phenotype in PC12 cells: a potential role for cellular raf kinases in neuronal growth factor signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

Integrin activation by R-ras.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

Sarcoma viruses carrying ras oncogenes induce differentiation-associated properties in a neuronal cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

Microinjection of the ras oncogene protein into PC12 cells induces morphological differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

7 January 2021

Retinoids in cancer prevention and therapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

7 January 2021

Refolding and purification of Ras proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

7 January 2021

Transformation of mammalian cells by constitutively active MAP kinase kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

7 January 2021

An NMR comparison of the changes produced by different guanosine 5'-triphosphate analogs in wild-type and oncogenic mutant p21ras

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

7 January 2021

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

1 reference

7 January 2021

Activation of MEK family kinases requires phosphorylation of two conserved Ser/Thr residues.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202517

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1202517

1 reference

Dimensions Publication ID

29 July 2017

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1 reference