(Q33864504)

29 July 2017

title

A cell-based high-throughput assay for the screening of small-molecule inhibitors of p53-MDM2 interaction (English)

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29 July 2017

Jing Li

1

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29 July 2017

Shuyong Zhang

2

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29 July 2017

Linghuan Gao

3

1 reference

29 July 2017

Ying Chen

4

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29 July 2017

Xin Xie

5

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29 July 2017

language of work or name

1 reference

1 April 2011

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Journal of Biomolecular Screening

29 July 2017

published in

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29 July 2017

volume

16

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29 July 2017

issue

4

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29 July 2017

page(s)

450-456

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29 July 2017

cites work

Surfing the p53 network

1 reference

https://api.crossref.org/works/10.1177%2F1087057111399191

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111399191

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111399191

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111399191

Discovery of a nanomolar inhibitor of the human murine double minute 2 (MDM2)-p53 interaction through an integrated, virtual database screening strategy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111399191

Comparison of the NCI open database with seven large chemical structural databases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111399191

A nonpeptidic sulfonamide inhibits the p53-mdm2 interaction and activates p53-dependent transcription in mdm2-overexpressing cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111399191

A simple cell-based HTS assay system to screen for inhibitors of p53-Hdm2 protein-protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111399191

p53 alpha-Helix mimetics antagonize p53/MDM2 interaction and activate p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111399191

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111399191

Reverse MAPPIT: screening for protein-protein interaction modifiers in mammalian cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111399191

Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111399191

Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: a novel approach for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111399191

Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111399191

NMR indicates that the small molecule RITA does not block p53-MDM2 binding in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111399191

p53 as a target for anti-cancer drug development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111399191

WAF1, a potential mediator of p53 tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111399191

Substrate binding site in bovine chymotrypsin Aγ. Crystallographic study using peptide chloromethyl ketones as site-specific inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111399191

21 January 2018

Identifiers

DOI

10.1177/1087057111399191

1 reference

29 July 2017

1 reference