(Q33209208)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15558054%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

title

Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15558054%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15558054%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

Maria Masucci

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15558054%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

Galina Selivanova

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15558054%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

author name string

Natalia Issaeva

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15558054%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

Przemyslaw Bozko

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15558054%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

Marina Protopopova

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15558054%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

Lisette G G C Verhoef

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15558054%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

Aladdin Pramanik

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15558054%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

language of work or name

English

0 references

publication date

21 November 2004

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15558054%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15558054%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

volume

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15558054%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

page(s)

1321-1328

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15558054%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

issue

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15558054%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/nm1146

5 January 2020

exact match

0 references

cites work

Surfing the p53 network

1 reference

The IARC TP53 database: new online mutation analysis and recommendations to users

21 January 2018

1 reference

Inhibiting the p53-MDM2 interaction: an important target for cancer therapy

21 January 2018

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Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

21 January 2018

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Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo.

21 January 2018

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An N-terminal p14ARF peptide blocks Mdm2-dependent ubiquitination in vitro and can activate p53 in vivo

21 January 2018

1 reference

Differentiation of Hdm2-mediated p53 ubiquitination and Hdm2 autoubiquitination activity by small molecular weight inhibitors

21 January 2018

1 reference

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

21 January 2018

1 reference

Requirement for p53 and p21 to sustain G2 arrest after DNA damage

21 January 2018

1 reference

Disruption of p53 in human cancer cells alters the responses to therapeutic agents

21 January 2018

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Specific binding of proinsulin C-peptide to human cell membranes

21 January 2018

1 reference

p53 Latency. C-terminal domain prevents binding of p53 core to target but not to nonspecific DNA sequences.

21 January 2018

1 reference

Epstein-Barr virus nuclear protein 2 interacts with p300, CBP, and PCAF histone acetyltransferases in activation of the LMP1 promoter

21 January 2018

1 reference

Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein

21 January 2018

1 reference

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

21 January 2018

1 reference

Peptides from the amino terminal mdm-2-binding domain of p53, designed from conformational analysis, are selectively cytotoxic to transformed cells

21 January 2018

1 reference

Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

21 January 2018

1 reference

Polyubiquitination of p53 by a ubiquitin ligase activity of p300.

21 January 2018

1 reference

iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human.

21 January 2018

1 reference

p53 has a direct apoptogenic role at the mitochondria

21 January 2018

1 reference

Parc: a cytoplasmic anchor for p53.

21 January 2018

1 reference

Slow tight binding inhibition of proteinase K by a proteinaceous inhibitor: conformational alterations responsible for conferring irreversibility to the enzyme-inhibitor complex.

21 January 2018

1 reference

Mdm-2 binding and TAF(II)31 recruitment is regulated by hydrogen bond disruption between the p53 residues Thr18 and Asp21.

21 January 2018

1 reference

p300 regulates p53-dependent apoptosis after DNA damage in colorectal cancer cells by modulation of PUMA/p21 levels

21 January 2018

1 reference

p300/MDM2 complexes participate in MDM2-mediated p53 degradation

21 January 2018

1 reference

Biological significance of a small highly conserved region in the N terminus of the p53 tumour suppressor protein.

21 January 2018

1 reference

Regulation of mutant p53 temperature-sensitive DNA binding.

21 January 2018

1 reference

Allosteric regulation of the thermostability and DNA binding activity of human p53 by specific interacting proteins. CRC Cell Transformation Group

21 January 2018

1 reference

Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

21 January 2018

1 reference

Crystal structure of the tetramerization domain of the p53 tumor suppressor at 1.7 angstroms

21 January 2018

1 reference

Solution structure of the tetrameric minimum transforming domain of p53

21 January 2018

1 reference

Suppression of human colorectal carcinoma cell growth by wild-type p53

21 January 2018

1 reference

Selective toxicity of the tricyclic thiophene NSC 652287 in renal carcinoma cell lines: differential accumulation and metabolism

21 January 2018

1 reference

The single-stranded DNA end binding site of p53 coincides with the C-terminal regulatory region.

21 January 2018

1 reference

Control of cell growth by c-Myc in the absence of cell division

21 January 2018

1 reference

Transient excess of MYC activity can elicit genomic instability and tumorigenesis

21 January 2018

1 reference

CDC25A phosphatase is a target of E2F and is required for efficient E2F-induced S phase

21 January 2018

1 reference

Signaling to p53: breaking the MDM2-p53 circuit

21 January 2018

1 reference

7 January 2021

A matter of life and cell death

1 reference

7 January 2021

A small synthetic peptide, which inhibits the p53-hdm2 interaction, stimulates the p53 pathway in tumour cell lines

1 reference

7 January 2021

The initial evaluation of non-peptidic small-molecule HDM2 inhibitors based on p53-HDM2 complex structure

1 reference

7 January 2021

Mdm2 binding to a conformationally sensitive domain on p53 can be modulated by RNA

1 reference

7 January 2021

DNA protein cross-links produced by NSC 652287, a novel thiophene derivative active against human renal cancer cells.

1 reference

7 January 2021