(Q33869850)

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Methotrexate inhibits the first committed step of purine biosynthesis in mitogen-stimulated human T-lymphocytes: a metabolic basis for efficacy in rheumatoid arthritis?

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

Methotrexate inhibits the first committed step of purine biosynthesis in mitogen-stimulated human T-lymphocytes: a metabolic basis for efficacy in rheumatoid arthritis? (English)

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

rheumatoid arthritis

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

Catherine M. Hawrylowicz

4

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

author name string

Fairbanks LD

1

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

Rückemann K

2

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

Qiu Y

3

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

Richards DF

5

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

Swaminathan R

6

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

Kirschbaum B

7

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

Simmonds HA

8

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

language of work or name

0 references

publication date

1 August 1999

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

Biochemical Journal

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

342 ( Pt 1)

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

143-152

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

Protein measurement with the Folin phenol reagent

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220447

5 July 2018

Leflunomide inhibits pyrimidine de novo synthesis in mitogen-stimulated T-lymphocytes from healthy humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220447

5 July 2018

Immunosuppressive properties of methotrexate: apoptosis and clonal deletion of activated peripheral T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220447

5 July 2018

Methotrexate in rheumatoid arthritis: an update with focus on mechanisms involved in toxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220447

5 July 2018

Methotrexate and sulfasalazine promote adenosine release by a mechanism that requires ecto-5'-nucleotidase-mediated conversion of adenine nucleotides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220447

5 July 2018

Enzymes of nucleotide biosynthesis: differences between intact and lysed cells as well as between species and tissues can be important

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220447

5 July 2018

Possible mechanisms of action of methotrexate in patients with rheumatoid arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220447

5 July 2018

Mycophenolic acid and brequinar, inhibitors of purine and pyrimidine synthesis, block the glycosylation of adhesion molecules

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220447

5 July 2018

The antiinflammatory mechanism of methotrexate. Increased adenosine release at inflamed sites diminishes leukocyte accumulation in an in vivo model of inflammation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220447

5 July 2018

Experience with a chimeric monoclonal anti-CD4 antibody in the treatment of refractory rheumatoid arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220447

5 July 2018

The roles of uridine-cytidine kinase and CTP synthetase in the synthesis of CTP in malignant human T-lymphocytic cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220447

5 July 2018

Low-dose methotrexate in rheumatic diseases--efficacy, side effects, and risk factors for side effects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220447

5 July 2018

Methotrexate in rheumatoid arthritis. An update

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220447

5 July 2018

B cells as well as T cells form deoxynucleotides from either deoxyadenosine or deoxyguanosine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220447

5 July 2018

A new folate antimetabolite, 5,10-dideaza-5,6,7,8-tetrahydrofolate is a potent inhibitor of de novo purine synthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220447

5 July 2018

Antiproliferative effects of methotrexate on peripheral blood mononuclear cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220447

5 July 2018

Inhibition of in vitro vascular endothelial cell proliferation and in vivo neovascularization by low-dose methotrexate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220447

5 July 2018

Dose-related effects of methotrexate on purine and pyrimidine nucleotides and on cell-kinetic parameters in MOLT-4 malignant human T-lymphoblasts.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220447

5 July 2018

Sequence-, time- and dose-dependent synergism of methotrexate and 6-mercaptopurine in malignant human T-lymphoblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220447

5 July 2018

Polyglutamation of methotrexate. Is methotrexate a prodrug?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220447

5 July 2018

Methotrexate: mechanism of action in rheumatoid arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220447

5 July 2018

Methotrexate therapy in rheumatoid arthritis patients diminishes lectin-induced mononuclear cell proliferation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220447

5 July 2018

Methotrexate inhibits neutrophil function by stimulating adenosine release from connective tissue cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220447

5 July 2018

Antifolates induce inhibition of amido phosphoribosyltransferase in leukemia cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220447

5 July 2018

Regulation of the mammalian carbamoyl-phosphate synthetase II by effectors and phosphorylation. Altered affinity for ATP and magnesium ions measured using the ammonia-dependent part reaction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220447

5 July 2018

Molecular mechanism of methotrexate action in inflammation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220447

5 July 2018

Efficacy and safety of leflunomide compared with placebo and sulphasalazine in active rheumatoid arthritis: a double-blind, randomised, multicentre trial. European Leflunomide Study Group.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220447

29 October 2018

Cyclic AMP decreases the availability of 5-phosphoribosyl-1-pyrophosphate and decelerates de novo purine synthesis in rat hepatocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220447

29 October 2018

Importance of ribonucleotide availability to proliferating T-lymphocytes from healthy humans. Disproportionate expansion of pyrimidine pools and contrasting effects of de novo synthesis inhibitors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220447

29 October 2018

Immunologic studies of rheumatoid arthritis patients treated with methotrexate

1 reference

https://pubmed.ncbi.nlm.nih.gov/10432311

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purine nucleotide metabolism in phytohemagglutinin-induced human T lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/10432311

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of leukotriene B4 synthesis in neutrophils from patients with rheumatoid arthritis by a single oral dose of methotrexate

1 reference

https://pubmed.ncbi.nlm.nih.gov/10432311

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Methotrexate metabolism analysis in blood and liver of rheumatoid arthritis patients. Association with hepatic folate deficiency and formation of polyglutamates

1 reference

https://pubmed.ncbi.nlm.nih.gov/10432311

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of mannose incorporation into glycoproteins and dolichol-linked intermediates of Sarcoma 180 cells by 6-methylmercaptopurine ribonucleoside

1 reference

https://pubmed.ncbi.nlm.nih.gov/10432311

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The salvage of deoxycytidine into dCDP-diacylglycerol by macrophages and lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/10432311

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lack of immunosuppressive effect of low-dose oral methotrexate on lymphocytes in rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/10432311

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduction of leukocyte and interleukin-1 beta concentrations in the synovial fluid of rheumatoid arthritis patients treated with methotrexate

1 reference

https://pubmed.ncbi.nlm.nih.gov/10432311

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detailed immunohistologic evaluation of a methotrexate-induced nodule

1 reference

https://pubmed.ncbi.nlm.nih.gov/10432311

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell-type specific response of peripheral blood lymphocytes to methotrexate in the treatment of rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/10432311

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The influence of methotrexate pretreatment on 5-fluorouracil metabolism in L1210 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/10432311

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for direct inhibition of de novo purine synthesis in human MCF-7 breast cells as a principal mode of metabolic inhibition by methotrexate

1 reference

https://pubmed.ncbi.nlm.nih.gov/10432311

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1042/0264-6021:3420143

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

ResearchGate publication ID

0 references

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