(Q33877450)

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A novel bicistronic high-capacity gutless adenovirus vector that drives constitutive expression of herpes simplex virus type 1 thymidine kinase and tet-inducible expression of Flt3L for glioma therapeutics

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20375153%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

A novel bicistronic high-capacity gutless adenovirus vector that drives constitutive expression of herpes simplex virus type 1 thymidine kinase and tet-inducible expression of Flt3L for glioma therapeutics (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20375153%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

vector-borne disease

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1 reference

based on heuristic

inferred from title

Herpes simplex virus type 1

1 reference

based on heuristic

inferred from title

9

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20375153%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

Maria G. Castro

17

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30 January 2020

author name string

Mariana Puntel

1

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30 January 2020

A K M G Muhammad

2

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30 January 2020

Marianela Candolfi

3

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30 January 2020

Alireza Salem

4

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30 January 2020

Kader Yagiz

5

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30 January 2020

Catherine Farrokhi

6

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30 January 2020

Kurt M Kroeger

7

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30 January 2020

Weidong Xiong

8

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30 January 2020

Chunyan Liu

10

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30 January 2020

Niyati S Bondale

11

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30 January 2020

Jonathan Lerner

12

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30 January 2020

Robert N Pechnick

13

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30 January 2020

Donna Palmer

14

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30 January 2020

Philip Ng

15

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30 January 2020

Pedro R Lowenstein

16

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30 January 2020

publication date

7 April 2010

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30 January 2020

Journal of Virology

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30 January 2020

84

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30 January 2020

12

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30 January 2020

6007-6017

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30 January 2020

Study of the efficacy, biodistribution, and safety profile of therapeutic gutless adenovirus vectors as a prelude to a phase I clinical trial for glioblastoma

1 reference

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5 July 2018

Kupfer-type immunological synapse characteristics do not predict anti-brain tumor cytolytic T-cell function in vivo.

1 reference

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Gene therapy for brain cancer: combination therapies provide enhanced efficacy and safety.

1 reference

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Antiglioma immunological memory in response to conditional cytotoxic/immune-stimulatory gene therapy: humoral and cellular immunity lead to tumor regression

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5 July 2018

Large-scale production of high-quality helper-dependent adenoviral vectors using adherent cells in cell factories

1 reference

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5 July 2018

The PEPvIII-KLH (CDX-110) vaccine in glioblastoma multiforme patients

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Release of HMGB1 in response to proapoptotic glioma killing strategies: efficacy and neurotoxicity

1 reference

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5 July 2018

HMGB1 mediates endogenous TLR2 activation and brain tumor regression

1 reference

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5 July 2018

Biodistribution of an oncolytic adenovirus after intracranial injection in permissive animals: a comparative study of Syrian hamsters and cotton rats

1 reference

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5 July 2018

Designer therapies for glioblastoma multiforme

1 reference

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5 July 2018

Methods for the production of helper-dependent adenoviral vectors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876634

5 July 2018

Malignant gliomas in adults

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876634

5 July 2018

Topotecan enhances immune clearance of gliomas

1 reference

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5 July 2018

Treg depletion inhibits efficacy of cancer immunotherapy: implications for clinical trials

1 reference

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5 July 2018

High-capacity adenovirus vector-mediated anti-glioma gene therapy in the presence of systemic antiadenovirus immunity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876634

5 July 2018

Flt3L in combination with HSV1-TK-mediated gene therapy reverses brain tumor-induced behavioral deficits.

1 reference

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5 July 2018

Immunization against the transgene but not the TetON switch reduces expression from gutless adenoviral vectors in the brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876634

5 July 2018

Results of a phase I dendritic cell vaccine trial for malignant astrocytoma: potential interaction with adjuvant chemotherapy.

1 reference

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5 July 2018

Flt3L and TK gene therapy eradicate multifocal glioma in a syngeneic glioblastoma model.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876634

5 July 2018

One-year expression from high-capacity adenoviral vectors in the brains of animals with pre-existing anti-adenoviral immunity: clinical implications.

1 reference

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5 July 2018

Intracranial glioblastoma models in preclinical neuro-oncology: neuropathological characterization and tumor progression.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876634

5 July 2018

Optimization of adenoviral vector-mediated transgene expression in the canine brain in vivo, and in canine glioma cells in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876634

5 July 2018

Effective high-capacity gutless adenoviral vectors mediate transgene expression in human glioma cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876634

5 July 2018

Quantification of high-capacity helper-dependent adenoviral vector genomes in vitro and in vivo, using quantitative TaqMan real-time polymerase chain reaction.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876634

5 July 2018

Fms-like tyrosine kinase 3 ligand recruits plasmacytoid dendritic cells to the brain

1 reference

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Changing paradigms--an update on the multidisciplinary management of malignant glioma

1 reference

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5 July 2018

Regulatable gutless adenovirus vectors sustain inducible transgene expression in the brain in the presence of an immune response against adenoviruses.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876634

5 July 2018

Combining cytotoxic and immune-mediated gene therapy to treat brain tumors

1 reference

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5 July 2018

Combined immunostimulation and conditional cytotoxic gene therapy provide long-term survival in a large glioma model.

1 reference

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Gene therapy for malignant glioma: current clinical status

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5 July 2018

Inflammatory and anti-glioma effects of an adenovirus expressing human soluble Fms-like tyrosine kinase 3 ligand (hsFlt3L): treatment with hsFlt3L inhibits intracranial glioma progression.

1 reference

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Toxicity associated with repeated administration of first-generation adenovirus vectors does not occur with a helper-dependent vector.

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Peripheral infection with adenovirus causes unexpected long-term brain inflammation in animals injected intracranially with first-generation, but not with high-capacity, adenovirus vectors: toward realistic long-term neurological gene therapy for ch

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Frequently asked questions in the medical management of high-grade glioma: a short guide with practical answers.

1 reference

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1 reference

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Preexisting antiadenoviral immunity is not a barrier to efficient and stable transduction of the brain, mediated by novel high-capacity adenovirus vectors

1 reference

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29 October 2018

Identifiers

10.1128/JVI.00398-10

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20375153%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

PMC publication ID

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Europe PubMed Central

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30 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

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30 January 2020

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