(Q34233124)

English

Regulatable gutless adenovirus vectors sustain inducible transgene expression in the brain in the presence of an immune response against adenoviruses.

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10 January 2020

Regulatable gutless adenovirus vectors sustain inducible transgene expression in the brain in the presence of an immune response against adenoviruses (English)

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10 January 2020

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10 January 2020

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10 January 2020

Maria G. Castro

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10 January 2020

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Weidong Xiong

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10 January 2020

Shyam Goverdhana

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10 January 2020

Sandra A Sciascia

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10 January 2020

Marianela Candolfi

4

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10 January 2020

Jeffrey M Zirger

5

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10 January 2020

Gwendalyn D King

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10 January 2020

Gabriela Jaita

9

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10 January 2020

Chunyan Liu

10

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10 January 2020

Kurt Kroeger

11

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10 January 2020

Hasmik Agadjanian

12

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10 January 2020

Lali Medina-Kauwe

13

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10 January 2020

Donna Palmer

14

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10 January 2020

Philip Ng

15

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10 January 2020

Pedro R Lowenstein

16

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10 January 2020

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1 January 2006

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10 January 2020

Journal of Virology

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10 January 2020

80

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10 January 2020

1

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10 January 2020

27-37

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10 January 2020

Combined immunostimulation and conditional cytotoxic gene therapy provide long-term survival in a large glioma model.

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Regulated and Liver-Specific Tamarin Alpha Interferon Gene Delivery by a Helper-Dependent Adenoviral Vector

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Helper-dependent adenoviral vectors for gene therapy

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New complex Ad vectors incorporating both rtTA and tTS deliver tightly regulated transgene expression both in vitro and in vivo.

1 reference

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Tight control of transgene expression by lentivirus vectors containing second-generation tetracycline-responsive promoters.

1 reference

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A tetracycline-regulated adenovirus encoding dominant-negative caspase-9 is regulated in rat brain and protects against neurotoxin-induced cell death in vitro, but not in vivo.

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Regulated delivery of glial cell line-derived neurotrophic factor into rat striatum, using a tetracycline-dependent lentiviral vector

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Inflammatory and anti-glioma effects of an adenovirus expressing human soluble Fms-like tyrosine kinase 3 ligand (hsFlt3L): treatment with hsFlt3L inhibits intracranial glioma progression.

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Physical and infectious titers of helper-dependent adenoviral vectors: a method of direct comparison to the adenovirus reference material

1 reference

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Tight regulation from a single tet-off rAAV vector as demonstrated by flow cytometry and quantitative, real-time PCR.

1 reference

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Suicide gene therapy of human breast cancer in SCID mice model by the regulation of Tet-On

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Prolonged and inducible transgene expression in the liver using gutless adenovirus: a potential therapy for liver cancer.

1 reference

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Improved system for helper-dependent adenoviral vector production

1 reference

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Fatal systemic inflammatory response syndrome in a ornithine transcarbamylase deficient patient following adenoviral gene transfer

1 reference

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A novel combination of promoter and enhancers increases transgene expression in vascular smooth muscle cells in vitro and coronary arteries in vivo after adenovirus-mediated gene transfer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1317549

6 July 2018

In vivo ligand-inducible regulation of gene expression in a gutless adenoviral vector system

1 reference

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Construction of an rtTA2(s)-m2/tts(kid)-based transcription regulatory switch that displays no basal activity, good inducibility, and high responsiveness to doxycycline in mice and non-human primates

1 reference

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A single point mutation in ecdysone receptor leads to increased ligand specificity: implications for gene switch applications

1 reference

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6 July 2018

Evaluation of Tet-on system to avoid transgene down-regulation in ex vivo gene transfer to the CNS.

1 reference

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Progress and challenges in viral vector-mediated gene transfer to the brain.

1 reference

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Regulated and prolonged expression of mIFN(alpha) in immunocompetent mice mediated by a helper-dependent adenovirus vector

1 reference

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3PO, a novel nonviral gene delivery system using engineered Ad5 penton proteins

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Efficient FLPe recombinase enables scalable production of helper-dependent adenoviral vectors with negligible helper-virus contamination

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Switching on and off transgene expression within lactotrophic cells in the anterior pituitary gland in vivo

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Long-term transgene expression within the anterior pituitary gland in situ: impact on circulating hormone levels, cellular and antibody-mediated immune responses

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Transcriptional targeting to anterior pituitary lactotrophic cells using recombinant adenovirus vectors in vitro and in vivo in normal and estrogen/sulpiride-induced hyperplastic anterior pituitaries

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Exploring the sequence space for tetracycline-dependent transcriptional activators: novel mutations yield expanded range and sensitivity

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Peripheral infection with adenovirus causes unexpected long-term brain inflammation in animals injected intracranially with first-generation, but not with high-capacity, adenovirus vectors: toward realistic long-term neurological gene therapy for ch

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A tetracycline controlled activation/repression system with increased potential for gene transfer into mammalian cells

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Adenovirus-mediated regulable target gene expression in vivo

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Comparison of the human versus murine cytomegalovirus immediate early gene promoters for transgene expression by adenoviral vectors

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Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice

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A regulatory system for use in gene transfer

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Transcriptional activation by tetracyclines in mammalian cells

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1 reference

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1 reference

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1 reference

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28 October 2018

Strong promoters are the key to highly efficient, noninflammatory and noncytotoxic adenoviral-mediated transgene delivery into the brain in vivo

1 reference

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Cell type-specific expression in brain cell cultures from a short human cytomegalovirus major immediate early promoter depends on whether it is inserted into herpesvirus or adenovirus vectors

1 reference

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28 October 2018

Identifiers

10.1128/JVI.80.1.27-37.2006

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16352528%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

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1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16352528%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

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1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16352528%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

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