(Q33882620)

29 July 2017

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title

Clinical pharmacokinetics and pharmacodynamics of isepamicin (English)

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29 July 2017

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Tod M

1

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29 July 2017

Padoin C

series ordinal

2

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29 July 2017

Petitjean O

series ordinal

3

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29 July 2017

publication date

1 March 2000

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Clinical Pharmacokinetics

29 July 2017

published in

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29 July 2017

volume

38

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29 July 2017

issue

3

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29 July 2017

page(s)

205-223

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A statistical evaluation of the bactericidal effects of ceftibuten in combination with aminoglycosides and ciprofloxacin.

29 July 2017

cites work

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12 December 2020

Beta-lactam enhancement of aminoglycoside activity under conditions of reduced pH and oxygen tension that may exist in infected tissues

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12 December 2020

Calcium Antagonists and Renal Protection

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12 December 2020

Isepamicin (SCH 21420, 1-N-HAPA gentamicin B): microbiological characteristics including antimicrobial potency of spectrum of activity

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12 December 2020

An overview of the safety of isepamicin in adults.

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12 December 2020

Comparative study with enoxacin and netilmicin in a pharmacodynamic model to determine importance of ratio of antibiotic peak concentration to MIC for bactericidal activity and emergence of resistance

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12 December 2020

Molecular parameters involved in aminoglycoside nephrotoxicity

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12 December 2020

Validation and nephrotoxicity of a simplified once-daily aminoglycoside dosing schedule and guidelines for monitoring therapy

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12 December 2020

Significance of serum bactericidal activity in gram-negative bacillary bacteremia in patients with and without granulocytopenia

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12 December 2020

Auditory impairment in guinea pigs treated with isepamicin.

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12 December 2020

The importance of pharmacokinetic/pharmacodynamic surrogate markers to outcome. Focus on antibacterial agents

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12 December 2020

Pharmacokinetics of intramuscularly administered isepamicin in man

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12 December 2020

Efficacy and toxicity of single daily doses of amikacin and ceftriaxone versus multiple daily doses of amikacin and ceftazidime for infection in patients with cancer and granulocytopenia. The International Antimicrobial Therapy Cooperative Group of t

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12 December 2020

Stimulation of free radical formation by aminoglycoside antibiotics

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12 December 2020

Once daily aminoglycoside therapy. Is it less toxic than multiple daily doses and how should it be monitored?

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12 December 2020

Resistance to amikacin and isepamicin in rabbits with experimental endocarditis of an aac(6')-Ib-bearing strain of Klebsiella pneumoniae susceptible in vitro

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12 December 2020

Once-daily dosing decreases renal accumulation of gentamicin and netilmicin

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12 December 2020

Attenuation of aminoglycoside-induced cochlear damage with the metabolic antioxidant alpha-lipoic acid

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12 December 2020

[Sensitivity of Pseudomonas aeruginosa to amikacin and to isepamicin in surgery and in intensive care]

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12 December 2020

Antimicrobial activity of isepamicin (SCH21420, 1-N-HAPA gentamicin B) combinations with cefotaxime, ceftazidime, ceftriaxone, ciprofloxacin, imipenem, mezlocillin and piperacillin tested against gentamicin-resistant and susceptible gram-negative ba

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12 December 2020

Circadian variations in serum levels and the renal toxicity of aminoglycosides in patients

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12 December 2020

Adaptive resistance of Pseudomonas aeruginosa induced by aminoglycosides and killing kinetics in a rabbit endocarditis model

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12 December 2020

Simple measurement of isepamicin, a new aminoglycoside antibiotic, in guinea pig and human plasma, using high-performance liquid chromatography with ultraviolet detection

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12 December 2020

Formation of free radicals by gentamicin and iron and evidence for an iron/gentamicin complex

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12 December 2020

Pharmacokinetics of isepamicin

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12 December 2020

Single-dose accumulation pharmacokinetics of tobramycin and netilmicin in normal volunteers

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12 December 2020

Single daily dosing of aminoglycosides in immunocompromised adults: a systematic review

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12 December 2020

Cloning and characterization of an aminoglycoside 6'-N-acetyltransferase gene from Citrobacter freundii which confers an altered resistance profile

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12 December 2020

Effect of concomitant administration of piperacillin on the dispositions of isepamicin and gentamicin in patients with end-stage renal disease

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12 December 2020

In vivo uptake kinetics of aminoglycosides in the kidney cortex of rats.

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12 December 2020

Proposed molecular and cellular mechanism for aminoglycoside ototoxicity

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12 December 2020

Pharmacokinetics of gentamicin in the decompensed alcoholic cirrhotic patient. Therapeutic consequences

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12 December 2020

A critical reevaluation of the "therapeutic range" of aminoglycosides

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12 December 2020

Pharmacokinetics of isepamicin following a single administration by intravenous infusion or intramuscular injections.

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12 December 2020

Population pharmacokinetic study of amikacin administered once or twice daily to febrile, severely neutropenic adults

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12 December 2020

First-exposure adaptive resistance to aminoglycoside antibiotics in vivo with meaning for optimal clinical use.

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12 December 2020

Three molecular steps of aminoglycoside ototoxicity demonstrated in outer hair cells

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12 December 2020

Isepamicin in intensive care unit patients with nosocomial pneumonia: population pharmacokinetic-pharmacodynamic study.

1 reference

12 December 2020

Inherited susceptibility to aminoglycoside ototoxicity: genetic heterogeneity and clinical implications

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12 December 2020

Pharmacodynamics of amikacin in vitro and in mouse thigh and lung infections

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12 December 2020

Treatment failures with broad-spectrum antibiotics

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12 December 2020

Tolerance, pharmacokinetics and efficacy of once daily amikacin for treatment of Pseudomonas aeruginosa pulmonary exacerbations in cystic fibrosis patients

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12 December 2020

Correlation of antimicrobial pharmacokinetic parameters with therapeutic efficacy in an animal model

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12 December 2020

Pharmacokinetics of intravenously administered isepamicin in men.

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12 December 2020

Effect of hemodialysis on serum concentration of isepamicin in a patient with endstage renal failure

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12 December 2020

Iron chelators protect from aminoglycoside-induced cochleo- and vestibulo-toxicity

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12 December 2020

Comparison of in vitro activity of Sch 21420, a gentamicin B derivative, with those of amikacin, gentamicin, netilmicin, sisomicin, and tobramycin

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12 December 2020

Effect of isepamicin dosing scheme on concentration in cochlear tissue

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12 December 2020

Isepamicin disposition in subjects with various degrees of renal function

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12 December 2020

The postantibiotic effect of amikacin alone and in combination with piperacillin on gram-negative bacteria

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12 December 2020

Population pharmacokinetic analysis of new aminoglycosides, astromicin and isepamicin, and evaluation of Bayesian prediction method for approximation of individual clearance of drug.

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12 December 2020

Clinical response to aminoglycoside therapy: importance of the ratio of peak concentration to minimal inhibitory concentration

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12 December 2020

Netilmicin and gentamicin multidose kinetics in normal subjects

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12 December 2020

Single-dose pharmacokinetics of isepamicin in young and geriatric volunteers

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12 December 2020

The changing nature of aminoglycoside resistance mechanisms and the role of isepamicin--a new broad-spectrum aminoglycoside. The Aminoglycoside Resistance Study Groups.

1 reference

12 December 2020

Postanitbiotic and sub-MIC effects of azithromycin and isepamicin against Staphylococcus aureus and Escherichia coli.

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12 December 2020

Endobronchial pH. Relevance of aminoglycoside activity in gram-negative bacillary pneumonia

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12 December 2020

Meta-analyses are no longer required for determining the efficacy of single daily dosing of aminoglycosides

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12 December 2020

Single daily dose of aminoglycosides--a concept whose time has not yet come

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12 December 2020

Evaluation of a fluorescence polarization immunoassay procedure for quantitation of isepamicin, a new aminoglycoside antibiotic

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12 December 2020

Once-daily versus multiple-daily dosing of aminoglycosides

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12 December 2020

The pharmacodynamics of aminoglycosides

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12 December 2020

High-performance liquid chromatographic determination of isepamicin in plasma, urine and dialysate

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12 December 2020

Evaluation of the efficacy and safety of isepamicin compared with amikacin in the treatment of nosocomial pneumonia and septicaemia

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12 December 2020

[The neuromuscular blocking activity of isepamicin sulfate (HAPA-B) compared with other aminoglycoside antibiotics]

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12 December 2020

Pharmacokinetics and metabolism of 14C-isepamicin in humans following intravenous administration

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12 December 2020

Pharmacokinetics of isepamicin in paediatric patients

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12 December 2020

Isepamicin sulfate-induced sensorineural hearing loss in patients with the 1555 A-->G mitochondrial mutation

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12 December 2020

Factors affecting duration of in-vivo postantibiotic effect for aminoglycosides against gram-negative bacilli

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12 December 2020

Optimizing aminoglycoside therapy for nosocomial pneumonia caused by gram-negative bacteria

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12 December 2020

Activity of isepamicin and selection of permeability mutants to beta-lactams during aminoglycoside therapy of experimental endocarditis due to Klebsiella pneumoniae CF104 producing an aminoglycoside acetyltransferase 6' modifying enzyme and a TEM-3

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12 December 2020

Experience with a once-daily aminoglycoside program administered to 2,184 adult patients

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12 December 2020

Population pharmacokinetic study of isepamicin with intensive care unit patients

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12 December 2020

The postantibiotic effect: a review of in vitro and in vivo data

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12 December 2020

Amikacin levels in bronchial secretions of 10 pneumonia patients with respiratory support treated once daily versus twice daily

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12 December 2020

The most frequently occurring aminoglycoside resistance mechanisms--combined results of surveys in eight regions of the world. The Aminoglycoside Resistance Study Groups

1 reference

12 December 2020

Isepamicin once daily plus ceftriaxone versus amikacin plus ceftriaxone in febrile neutropenic patients.

1 reference

12 December 2020

Correlation of pharmacokinetic indices with therapeutic outcome in patients receiving aminoglycosides

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12 December 2020

Sulfhydryl compounds and antioxidants inhibit cytotoxicity to outer hair cells of a gentamicin metabolite in vitro

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12 December 2020

10.2165/00003088-200038030-00002

Identifiers

DOI

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Dimensions Publication ID

29 July 2017

1002581330

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