(Q33884992)

29 July 2017

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title

Metabolic engineering and directed evolution for the production of pharmaceuticals (English)

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29 July 2017

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Chartrain M

1

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29 July 2017

Salmon PM

series ordinal

2

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29 July 2017

Robinson DK

series ordinal

3

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29 July 2017

Buckland BC

series ordinal

4

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29 July 2017

1 April 2000

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Current Opinion in Biotechnology

29 July 2017

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29 July 2017

11

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29 July 2017

2

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29 July 2017

209-214

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Ethyl-substituted erythromycin derivatives produced by directed metabolic engineering

29 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900081-1

7 January 2021

Tolerance and specificity of polyketide synthases

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900081-1

7 January 2021

The specificity-conferring code of adenylation domains in nonribosomal peptide synthetases

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900081-1

7 January 2021

Novel erythromycins from a recombinant Saccharopolyspora erythraea strain NRRL 2338 pIG1. I. Fermentation, isolation and biological activity

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900081-1

7 January 2021

A chain initiation factor common to both modular and aromatic polyketide synthases

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900081-1

7 January 2021

Spontaneous priming of a downstream module in 6-deoxyerythronolide B synthase leads to polyketide biosynthesis

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900081-1

7 January 2021

Dissecting and exploiting intermodular communication in polyketide synthases

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900081-1

7 January 2021

Evaluating precursor-directed biosynthesis towards novel erythromycins through in vitro studies on a bimodular polyketide synthase

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900081-1

7 January 2021

Dissecting the role of acyltransferase domains of modular polyketide synthases in the choice and stereochemical fate of extender units

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900081-1

7 January 2021

Harnessing the biosynthetic code: combinations, permutations, and mutations

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900081-1

7 January 2021

Mechanism and specificity of the terminal thioesterase domain from the erythromycin polyketide synthase

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900081-1

7 January 2021

Ectopic expression of the minimal whiE polyketide synthase generates a library of aromatic polyketides of diverse sizes and shapes

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900081-1

7 January 2021

The Streptomyces peucetius dpsY anddnrX Genes Govern Early and Late Steps of Daunorubicin and Doxorubicin Biosynthesis

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900081-1

7 January 2021

Doxorubicin overproduction in Streptomyces peucetius: cloning and characterization of the dnrU ketoreductase and dnrV genes and the doxA cytochrome P-450 hydroxylase gene

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900081-1

7 January 2021

A two-plasmid system for the glycosylation of polyketide antibiotics: bioconversion of epsilon-rhodomycinone to rhodomycin D

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900081-1

7 January 2021

Production of the antitumor drug epirubicin (4'-epidoxorubicin) and its precursor by a genetically engineered strain of Streptomyces peucetius

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900081-1

7 January 2021

Self-sufficient biosynthesis of pregnenolone and progesterone in engineered yeast

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900081-1

7 January 2021

Novel biosynthetic approaches to the production of unnatural amino acids using transaminases

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900081-1

7 January 2021

Production of the carotenoids lycopene, beta-carotene, and astaxanthin in the food yeast Candida utilis

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900081-1

7 January 2021

Production of lycopene by the food yeast, Candida utilis that does not naturally synthesize carotenoid

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900081-1

7 January 2021

Increased carotenoid production by the food yeast Candida utilis through metabolic engineering of the isoprenoid pathway.

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900081-1

7 January 2021

Engineered isoprenoid pathway enhances astaxanthin production in Escherichia coli

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900081-1

7 January 2021

Biocatalysis for pharmaceuticals--status and prospects for a key technology

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900081-1

7 January 2021

Isolation and characterization of indene bioconversion genes from Rhodococcus strain I24

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900081-1

7 January 2021

Novel approaches for discovering industrial enzymes

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900081-1

7 January 2021

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900081-1

1 reference

7 January 2021

Applications of oxidoreductases

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900081-1

7 January 2021

Dehalogenases applied to industrial-scale biocatalysis

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900081-1

7 January 2021

The power of evolution: accessing the synthetic potential of P450s

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900081-1

7 January 2021

Chemical modification of enzymes for enhanced functionality

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900081-1

7 January 2021

Biocatalysts for clean industrial products and processes

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900081-1

7 January 2021

Improved green fluorescent protein by molecular evolution using DNA shuffling.

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900081-1

7 January 2021

Directed evolution of a para-nitrobenzyl esterase for aqueous-organic solvents

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900081-1

7 January 2021

Directed evolution of biocatalysts

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900081-1

7 January 2021

Directed evolution of an esterase for the stereoselective resolution of a key intermediate in the synthesis of epothilones

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900081-1

7 January 2021

Molecular evolution by staggered extension process (StEP) in vitro recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900081-1

7 January 2021

Laboratory evolution of peroxide-mediated cytochrome P450 hydroxylation

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900081-1

7 January 2021

A high-throughput digital imaging screen for the discovery and directed evolution of oxygenases

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900081-1

7 January 2021

A general strategy for enzyme engineering

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900081-1

7 January 2021

Directed evolution converts subtilisin E into a functional equivalent of thermitase

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900081-1

7 January 2021

Directed evolution of a thermostable esterase.

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900081-1

7 January 2021

A structural view of evolutionary divergence

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900081-1

7 January 2021

Functional expression of horseradish peroxidase in E. coli by directed evolution

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900081-1

7 January 2021

The Streptomyces peucetius dpsC Gene Determines the Choice of Starter Unit in Biosynthesis of the Daunorubicin Polyketide

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.1128/JB.181.15.4690-4695.1999

Identifiers

DOI

10.1016/S0958-1669(00)00081-1

1 reference

29 July 2017

1 reference