(Q33887012)

29 July 2017

1 reference

title

Why do neuroprotective drugs work in animals but not humans? (English)

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29 July 2017

1

DeGraba TJ

1 reference

29 July 2017

Pettigrew LC

2

1 reference

29 July 2017

1 May 2000

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29 July 2017

1 reference

29 July 2017

18

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29 July 2017

2

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29 July 2017

475-493

1 reference

Safety, tolerability, and pharmacokinetics of the N-methyl-D-aspartate antagonist dextrorphan in patients with acute stroke. Dextrorphan Study Group

29 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0733-8619%2805%2970203-6

7 January 2021

Neuroprotection of the brain during cardiopulmonary bypass: a randomized trial of remacemide during coronary artery bypass in 171 patients.

1 reference

https://api.crossref.org/works/10.1016%2FS0733-8619%2805%2970203-6

7 January 2021

Thresholds in cerebral ischemia - the ischemic penumbra

1 reference

https://api.crossref.org/works/10.1016%2FS0733-8619%2805%2970203-6

7 January 2021

Interleukin-8 and the chemokine family.

1 reference

https://api.crossref.org/works/10.1016%2FS0733-8619%2805%2970203-6

7 January 2021

Imaging developing brain infarction

1 reference

https://api.crossref.org/works/10.1016%2FS0733-8619%2805%2970203-6

7 January 2021

Magnetic resonance imaging of acute stroke

1 reference

https://api.crossref.org/works/10.1016%2FS0733-8619%2805%2970203-6

7 January 2021

Elevation of the Extracellular Concentrations of Glutamate and Aspartate in Rat Hippocampus During Transient Cerebral Ischemia Monitored by Intracerebral Microdialysis

1 reference

https://api.crossref.org/works/10.1016%2FS0733-8619%2805%2970203-6

7 January 2021

Increase in vascular permeability induced by leukotriene B4 and the role of polymorphonuclear leukocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0733-8619%2805%2970203-6

7 January 2021

Interobserver agreement for the assessment of handicap in stroke patients

1 reference

https://api.crossref.org/works/10.1016%2FS0733-8619%2805%2970203-6

7 January 2021

Focal Brain Ischemia in the Rat: Methods for Reproducible Neocortical Infarction Using Tandem Occlusion of the Distal Middle Cerebral and Ipsilateral Common Carotid Arteries

1 reference

https://api.crossref.org/works/10.1016%2FS0733-8619%2805%2970203-6

7 January 2021

Measurements of acute cerebral infarction: a clinical examination scale

1 reference

https://api.crossref.org/works/10.1016%2FS0733-8619%2805%2970203-6

7 January 2021

A new model of temporary focal neocortical ischemia in the rat

1 reference

https://api.crossref.org/works/10.1016%2FS0733-8619%2805%2970203-6

7 January 2021

Correlation between amino acid release and neuropathologic outcome in rat brain following middle cerebral artery occlusion

1 reference

https://api.crossref.org/works/10.1016%2FS0733-8619%2805%2970203-6

7 January 2021

Caspase inhibitor affords neuroprotection with delayed administration in a rat model of neonatal hypoxic-ischemic brain injury

1 reference

https://api.crossref.org/works/10.1016%2FS0733-8619%2805%2970203-6

7 January 2021

Glutamate neurotoxicity and diseases of the nervous system

1 reference

https://api.crossref.org/works/10.1016%2FS0733-8619%2805%2970203-6

7 January 2021

A randomized dose-response trial of citicoline in acute ischemic stroke patients. Citicoline Stroke Study Group

1 reference

https://api.crossref.org/works/10.1016%2FS0733-8619%2805%2970203-6

7 January 2021

Developmental cell death: morphological diversity and multiple mechanisms

1 reference

https://api.crossref.org/works/10.1016%2FS0733-8619%2805%2970203-6

7 January 2021

Caspases: the executioners of apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0733-8619%2805%2970203-6

7 January 2021

The role of inflammation after acute stroke: utility of pursuing anti-adhesion molecule therapy.

1 reference

https://api.crossref.org/works/10.1016%2FS0733-8619%2805%2970203-6

7 January 2021

Progression in acute stroke: value of the initial NIH stroke scale score on patient stratification in future trials

1 reference

https://api.crossref.org/works/10.1016%2FS0733-8619%2805%2970203-6

7 January 2021

Threshold of calcium disturbances after focal cerebral ischemia in rats. Implications of the window of therapeutic opportunity.

1 reference

https://api.crossref.org/works/10.1016%2FS0733-8619%2805%2970203-6

7 January 2021

Temporal relation of calcium-calmodulin binding and neuronal damage after global ischemia in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0733-8619%2805%2970203-6

7 January 2021

Increased endothelial expression of intercellular adhesion molecule-1 in symptomatic versus asymptomatic human carotid atherosclerotic plaque

1 reference

https://api.crossref.org/works/10.1016%2FS0733-8619%2805%2970203-6

7 January 2021

Lubeluzole in acute ischemic stroke. A double-blind, placebo-controlled phase II trial. Lubeluzole International Study Group

1 reference

https://api.crossref.org/works/10.1016%2FS0733-8619%2805%2970203-6

7 January 2021

Intra-arterial prourokinase for acute ischemic stroke. The PROACT II study: a randomized controlled trial. Prolyse in Acute Cerebral Thromboembolism.

1 reference

https://api.crossref.org/works/10.1016%2FS0733-8619%2805%2970203-6

7 January 2021

Interrater reliability of the NIH stroke scale.

1 reference

https://api.crossref.org/works/10.1016%2FS0733-8619%2805%2970203-6

7 January 2021

The role of glutamate in neurotransmission and in neurologic disease

1 reference

https://api.crossref.org/works/10.1016%2FS0733-8619%2805%2970203-6

7 January 2021

Lubeluzole treatment of acute ischemic stroke. The US and Canadian Lubeluzole Ischemic Stroke Study Group

1 reference

https://api.crossref.org/works/10.1016%2FS0733-8619%2805%2970203-6

7 January 2021

Rodent models of stroke limitations. What can we learn from recent clinical trials of thrombolysis?

1 reference

https://api.crossref.org/works/10.1016%2FS0733-8619%2805%2970203-6

7 January 2021

Safety and tolerability of the glutamate antagonist CGS 19755 (Selfotel) in patients with acute ischemic stroke. Results of a phase IIa randomized trial

1 reference

https://api.crossref.org/works/10.1016%2FS0733-8619%2805%2970203-6

7 January 2021

CGS-19755, a competitive NMDA receptor antagonist, reduces calcium-calmodulin binding and improves outcome after global cerebral ischemia.

1 reference

https://api.crossref.org/works/10.1016%2FS0733-8619%2805%2970203-6

7 January 2021

Ischemic penumbra: The therapeutic window

1 reference

https://api.crossref.org/works/10.1016%2FS0733-8619%2805%2970203-6

7 January 2021

Lipopolysaccharide-induced production of tumor necrosis factor activity in rats with and without risk factors for stroke.

1 reference

https://api.crossref.org/works/10.1016%2FS0733-8619%2805%2970203-6

7 January 2021

Microvascular basal lamina antigens disappear during cerebral ischemia and reperfusion

1 reference

https://api.crossref.org/works/10.1016%2FS0733-8619%2805%2970203-6

7 January 2021

Progressive derangement of periinfarct viable tissue in ischemic stroke.

1 reference

https://api.crossref.org/works/10.1016%2FS0733-8619%2805%2970203-6

7 January 2021

Functional recovery of cortical neurons as related to degree and duration of ischemia

1 reference

https://api.crossref.org/works/10.1016%2FS0733-8619%2805%2970203-6

7 January 2021

In vivo studies of energy metabolism in experimental cerebral ischemia using topical magnetic resonance. Changes in 31P-nuclear magnetic resonance spectra compared with electroencephalograms and regional cerebral blood flow.

1 reference

https://api.crossref.org/works/10.1016%2FS0733-8619%2805%2970203-6

7 January 2021

Viability thresholds and the penumbra of focal ischemia

1 reference

https://api.crossref.org/works/10.1016%2FS0733-8619%2805%2970203-6

7 January 2021

Criteria for valid preclinical trials using animal stroke models

1 reference

https://api.crossref.org/works/10.1016%2FS0733-8619%2805%2970203-6

7 January 2021

Early loss of somatostatin neurons in dentate hilus after cerebral ischemia in the rat precedes CA-1 pyramidal cell loss.

1 reference

https://api.crossref.org/works/10.1016%2FS0733-8619%2805%2970203-6

7 January 2021

Thresholds of focal cerebral ischemia in awake monkeys

1 reference

https://api.crossref.org/works/10.1016%2FS0733-8619%2805%2970203-6

7 January 2021

Temporal thresholds for neocortical infarction in rats subjected to reversible focal cerebral ischemia

1 reference

https://api.crossref.org/works/10.1016%2FS0733-8619%2805%2970203-6

7 January 2021

Delayed neuronal death in the gerbil hippocampus following ischemia

1 reference

https://api.crossref.org/works/10.1016%2FS0733-8619%2805%2970203-6

7 January 2021

Calcium-related damage in ischemia

1 reference

https://api.crossref.org/works/10.1016%2FS0733-8619%2805%2970203-6

7 January 2021

Evidence supporting a role for programmed cell death in focal cerebral ischemia in rats.

1 reference

https://api.crossref.org/works/10.1016%2FS0733-8619%2805%2970203-6

7 January 2021

Quantitation of perivascular monocytes and macrophages around cerebral blood vessels of hypertensive and aged rats.

1 reference

https://api.crossref.org/works/10.1016%2FS0733-8619%2805%2970203-6

7 January 2021

Quantitative effects of cerebral infarction on spatial learning in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0733-8619%2805%2970203-6

7 January 2021

NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones

1 reference

https://api.crossref.org/works/10.1016%2FS0733-8619%2805%2970203-6

7 January 2021

DNA damage consistent with apoptosis in transient focal ischaemic neocortex.

1 reference

https://api.crossref.org/works/10.1016%2FS0733-8619%2805%2970203-6

7 January 2021

Adhesion molecules on normotensive and hypertensive rat brain endothelial cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0733-8619%2805%2970203-6

7 January 2021

Penumbral tissues salvaged by reperfusion following middle cerebral artery occlusion in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0733-8619%2805%2970203-6

7 January 2021

Cell adhesion molecule mediates endothelial cell injury caused by activated neutrophils

1 reference

https://api.crossref.org/works/10.1016%2FS0733-8619%2805%2970203-6

7 January 2021

Pathological changes induced in cerebrocortical neurons by phencyclidine and related drugs

1 reference

https://api.crossref.org/works/10.1016%2FS0733-8619%2805%2970203-6

7 January 2021

Delayed hippocampal damage in humans following cardiorespiratory arrest.

1 reference

https://api.crossref.org/works/10.1016%2FS0733-8619%2805%2970203-6

7 January 2021

Microtubular proteolysis in focal cerebral ischemia.

1 reference

https://api.crossref.org/works/10.1016%2FS0733-8619%2805%2970203-6

7 January 2021

A new model of bilateral hemispheric ischemia in the unanesthetized rat

1 reference

https://api.crossref.org/works/10.1016%2FS0733-8619%2805%2970203-6

7 January 2021

Temporal profile of neuronal damage in a model of transient forebrain ischemia

1 reference

https://api.crossref.org/works/10.1016%2FS0733-8619%2805%2970203-6

7 January 2021

Cerebral vascular accidents in patients over the age of 60. II. Prognosis

1 reference

https://api.crossref.org/works/10.1016%2FS0733-8619%2805%2970203-6

7 January 2021

Atherosclerosis — An Inflammatory Disease

1 reference

https://api.crossref.org/works/10.1016%2FS0733-8619%2805%2970203-6

7 January 2021

Excitotoxins: possible mechanisms of action

1 reference

https://api.crossref.org/works/10.1016%2FS0733-8619%2805%2970203-6

7 January 2021

Glutamate and the pathophysiology of hypoxic--ischemic brain damage

1 reference

https://api.crossref.org/works/10.1016%2FS0733-8619%2805%2970203-6

7 January 2021

Pathophysiology and treatment of focal cerebral ischemia. Part II: Mechanisms of damage and treatment

1 reference

https://api.crossref.org/works/10.1016%2FS0733-8619%2805%2970203-6

7 January 2021

Release of proinflammatory and prothrombotic mediators in the brain and peripheral circulation in spontaneously hypertensive and normotensive Wistar-Kyoto rats

1 reference

https://api.crossref.org/works/10.1016%2FS0733-8619%2805%2970203-6

7 January 2021

The density and distribution of ischemic brain injury in the rat following 2?10 min of forebrain ischemia

1 reference

https://api.crossref.org/works/10.1016%2FS0733-8619%2805%2970203-6

7 January 2021

DNA scission after focal brain ischemia. Temporal differences in two species.

1 reference

https://api.crossref.org/works/10.1016%2FS0733-8619%2805%2970203-6

7 January 2021

Clinical outcome in ischemic stroke predicted by early diffusion-weighted and perfusion magnetic resonance imaging: a preliminary analysis

1 reference

https://api.crossref.org/works/10.1016%2FS0733-8619%2805%2970203-6

7 January 2021

Acute human stroke studied by whole brain echo planar diffusion-weighted magnetic resonance imaging

1 reference

https://api.crossref.org/works/10.1016%2FS0733-8619%2805%2970203-6

7 January 2021

Tissue destruction by neutrophils

1 reference

https://api.crossref.org/works/10.1016%2FS0733-8619%2805%2970203-6

7 January 2021

Animal models of stroke: are they relevant to human disease?

1 reference

https://api.crossref.org/works/10.1016%2FS0733-8619%2805%2970203-6

7 January 2021

Cell death: the significance of apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0733-8619%2805%2970203-6

7 January 2021

Increased therapeutic efficacy with rt-PA and anti-CD18 antibody treatment of stroke in the rat.

1 reference

https://api.crossref.org/works/10.1016%2FS0733-8619%2805%2970203-6

7 January 2021

Animal stroke models. They are relevant to human disease

1 reference

https://api.crossref.org/works/10.1016%2FS0733-8619%2805%2970203-6

7 January 2021

10.1016/S0733-8619(05)70203-6

Identifiers

DOI

1 reference

29 July 2017

1 reference

PubMed ID

10757837