(Q33888219)

29 July 2017

title

Geldanamycin as a potential anti-cancer agent: its molecular target and biochemical activity (English)

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29 July 2017

3

Mimnaugh E

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29 July 2017

1

Neckers L

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29 July 2017

2

Schulte TW

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29 July 2017

publication date

1 January 1999

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Investigational New Drugs

29 July 2017

published in

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29 July 2017

volume

17

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29 July 2017

issue

4

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29 July 2017

page(s)

361-373

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Association of the beta gamma subunits of trimeric GTP-binding proteins with 90-kDa heat shock protein, hsp90.

29 July 2017

cites work

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12 December 2020

Spontaneous overexpression of heat-shock proteins in Ehrlich ascites carcinoma cells during in vivo growth

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12 December 2020

Expression of focal adhesion kinase gene and invasive cancer

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12 December 2020

Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4

1 reference

12 December 2020

Significance of heat-shock protein-90 as a prognostic indicator in breast-cancer.

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12 December 2020

Evidence for reversible, non-microtubule and non-microfilament-dependent nuclear translocation of hsp90 after heat shock in human fibroblasts

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12 December 2020

Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

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12 December 2020

Autophosphorylation of grp94 (endoplasmin)

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12 December 2020

The benzoquinone ansamycin geldanamycin stimulates proteolytic degradation of focal adhesion kinase

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12 December 2020

The native structure of the activated Raf protein kinase is a membrane-bound multi-subunit complex

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12 December 2020

ATP-binding properties of human Hsp90.

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12 December 2020

Heat shock protein 84 forms a complex with mutant p53 protein predominantly within a cytoplasmic compartment of the cell

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12 December 2020

The heat shock protein 83 (Hsp83) is required for Raf-mediated signalling in Drosophila

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12 December 2020

Hsp90-mediated folding of the lymphoid cell kinase p56lck

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12 December 2020

Heat-shock protein hsp90 governs the activity of pp60v-src kinase

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12 December 2020

The 90-kDa molecular chaperone family: structure, function, and clinical applications. A comprehensive review

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12 December 2020

Regulation of Hsp90 ATPase activity by tetratricopeptide repeat (TPR)-domain co-chaperones

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12 December 2020

Physical interaction of mammalian CDC37 with CDK4

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12 December 2020

Association of Hsp90 with cellular Src-family kinases in a cell-free system correlates with altered kinase structure and function

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12 December 2020

Anti-androgens and the mutated androgen receptor of LNCaP cells: differential effects on binding affinity, heat-shock protein interaction, and transcription activation

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12 December 2020

Subunit composition of the molybdate-stabilized "8-9 S" nontransformed estradiol receptor purified from calf uterus

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12 December 2020

Clinical and biological significance of HSP89 alpha in human breast cancer

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12 December 2020

Targeting of the protein chaperone, HSP90, by the transformation suppressing agent, radicicol

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12 December 2020

Sequence and regulation of a gene encoding a human 89-kilodalton heat shock protein

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12 December 2020

The retinoblastoma protein and cell cycle control

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12 December 2020

Nucleotides and two functional states of hsp90

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12 December 2020

The native v-Raf.hsp90.p50 heterocomplex contains a novel immunophilin of the FK506 binding class

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12 December 2020

The 90-kDa heat shock protein, HSP90, binds and protects casein kinase II from self-aggregation and enhances its kinase activity.

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12 December 2020

Mutational analysis of Hsp90 function: interactions with a steroid receptor and a protein kinase

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12 December 2020

Constitutive overexpression of a 89 kDa heat shock protein gene in the HBL100 human mammary cell line converted to a tumorigenic phenotype by the EJ/T24 Harvey-ras oncogene

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12 December 2020

Antibiotic radicicol binds to the N-terminal domain of Hsp90 and shares important biologic activities with geldanamycin

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12 December 2020

Disruption of the Raf-1-Hsp90 Molecular Complex Results in Destabilization of Raf-1 and Loss of Raf-1-Ras Association

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12 December 2020

Cdc37 is a molecular chaperone with specific functions in signal transduction

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12 December 2020

An atypical topoisomerase II from Archaea with implications for meiotic recombination

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12 December 2020

Effects of herbimycin derivatives on src oncogene function in relation to antitumor activity

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12 December 2020

A pathway of multi-chaperone interactions common to diverse regulatory proteins: estrogen receptor, Fes tyrosine kinase, heat shock transcription factor Hsf1, and the aryl hydrocarbon receptor

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12 December 2020

Overexpression of the focal adhesion kinase (p125FAK) in invasive human tumors

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12 December 2020

The glucose-regulated proteins (GRP78 and GRP94): functions, gene regulation, and applications

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12 December 2020

Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent

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12 December 2020

Interaction Between the Rous Sarcoma Virus Transforming Protein and Two Cellular Phosphoproteins: Analysis of the Turnover and Distribution of This Complex

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12 December 2020

Binding of p23 and hsp90 during assembly with the progesterone receptor

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12 December 2020

The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin

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12 December 2020

Molecular cloning of human FKBP51 and comparisons of immunophilin interactions with Hsp90 and progesterone receptor

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12 December 2020

Expression of recombinant human casein kinase II and recombinant heat shock protein 90 in Escherichia coli and characterization of their interactions

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12 December 2020

G1 phase progression: cycling on cue

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12 December 2020

Reduced levels of hsp90 compromise steroid receptor action in vivo

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12 December 2020

ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone in vivo

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12 December 2020

The protein-protein complex between pp60v-src and hsp90 is stabilized by molybdate, vanadate, tungstate, and an endogenous cytosolic metal

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12 December 2020

A cellular protein that associates with the transforming protein of Rous sarcoma virus is also a heat-shock protein

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12 December 2020

Nuclear localization of two steroid receptor-associated proteins, hsp90 and p59

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12 December 2020

In vitro synthesis of G protein beta gamma dimers

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12 December 2020

ATP induces a conformational change of the 90-kDa heat shock protein (hsp90).

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12 December 2020

Progesterone receptor structure and function altered by geldanamycin, an hsp90-binding agent

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12 December 2020

Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin

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12 December 2020

Mammalian membrane-bound adenylyl cyclases

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12 December 2020

Expression and roles of heat shock proteins in human breast cancer.

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12 December 2020

Depletion of p185erbB2, Raf-1 and mutant p53 proteins by geldanamycin derivatives correlates with antiproliferative activity

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12 December 2020

Geldanamycin selectively destabilizes and conformationally alters mutated p53

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12 December 2020

Localization and characterization of the 86- and 84-kDa heat shock proteins in Hepa 1c1c7 cells

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12 December 2020

Interaction of the Rous sarcoma virus protein pp60src with the cellular proteins pp50 and pp90.

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12 December 2020

Raf exists in a native heterocomplex with hsp90 and p50 that can be reconstituted in a cell-free system

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12 December 2020

Geldanamycin-stimulated destabilization of mutated p53 is mediated by the proteasome in vivo

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12 December 2020

Unusual expression and localization of heat-shock proteins in human tumor cells

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12 December 2020

The hsp90-binding antibiotic geldanamycin decreases Raf levels and epidermal growth factor signaling without disrupting formation of signaling complexes or reducing the specific enzymatic activity of Raf kinase

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12 December 2020

High constitutive expression of heat shock protein 90α in human acute leukemia cells

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12 December 2020

A role for Hsp90 in cell cycle control: Wee1 tyrosine kinase activity requires interaction with Hsp90.

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12 December 2020

The Ydj1 molecular chaperone facilitates formation of active p60v-src in yeast

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12 December 2020

Phenotypic change from transformed to normal induced by benzoquinonoid ansamycins accompanies inactivation of p60src in rat kidney cells infected with Rous sarcoma virus

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12 December 2020

Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone

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12 December 2020

Tyrosine kinase inhibitor herbimycin A reduces the stability of cyclin-dependent kinase Cdk6 protein in T-cells

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12 December 2020

Association of the Transforming Proteins of Rous, Fujinami, and Y73 Avian Sarcoma Viruses with the Same Two Cellular Proteins

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12 December 2020

Interaction between Cdc37 and Cdk4 in human cells

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12 December 2020

A cyclophilin function in Hsp90-dependent signal transduction

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12 December 2020

The amino-terminal domain of heat shock protein 90 (hsp90) that binds geldanamycin is an ATP/ADP switch domain that regulates hsp90 conformation

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12 December 2020

Selective Interaction of hsp90 with an Estrogen Receptor Ligand-binding Domain Containing a Point Mutation

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12 December 2020

Recent Advances in the Study of hsp90 Structure and Mechanism of Action

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12 December 2020

Biochemical properties of p60v-src mutants that induce different cell transformation parameters

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12 December 2020

The specific interaction of the Rous sarcoma virus transforming protein, pp60src, with two cellular proteins

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12 December 2020

Herbimycin A induces the 20 S proteasome- and ubiquitin-dependent degradation of receptor tyrosine kinases

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12 December 2020

Interaction of Endoplasmic Reticulum Chaperone GRP94 with Peptide Substrates Is Adenine Nucleotide-independent

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12 December 2020

The carboxy-terminal region of mammalian HSP90 is required for its dimerization and function in vivo

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12 December 2020

Mutant conformation of p53 translated in vitro or in vivo requires functional HSP90.

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12 December 2020

Role of the protein chaperone YDJ1 in establishing Hsp90-mediated signal transduction pathways

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12 December 2020

Preclinical pharmacologic evaluation of geldanamycin as an antitumor agent

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12 December 2020

Hsp90 chaperonins possess ATPase activity and bind heat shock transcription factors and peptidyl prolyl isomerases.

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12 December 2020

Purification and Partial Molecular Characterization of GRP94, an ER Resident Chaperone

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12 December 2020

Differential effects of the reversible thiol-reactive agents arsenite and methyl methanethiosulfonate on steroid binding by the glucocorticoid receptor

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12 December 2020

A new member of the hsp90 family of molecular chaperones interacts with the retinoblastoma protein during mitosis and after heat shock

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12 December 2020

Identification of a protein with homology to hsp90 that binds the type 1 tumor necrosis factor receptor

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12 December 2020

In vivo analysis of the Hsp90 cochaperone Sti1 (p60)

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12 December 2020

Transit of pp60v-src to the plasma membrane

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12 December 2020

Assessment of the ATP binding properties of Hsp90.

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12 December 2020

Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation

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12 December 2020

Polyubiquitination and proteasomal degradation of the p185c-erbB-2 receptor protein-tyrosine kinase induced by geldanamycin

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12 December 2020

Depletion of the erbB-2 gene product p185 by benzoquinoid ansamycins

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12 December 2020

The G protein gamma subunit. Requirements for dimerization with beta subunits

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12 December 2020

Stable and specific binding of heat shock protein 90 by geldanamycin disrupts glucocorticoid receptor function in intact cells

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12 December 2020

A molecular clamp in the crystal structure of the N-terminal domain of the yeast Hsp90 chaperone

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12 December 2020

Inhibition of the oncogene product p185erbB-2 in vitro and in vivo by geldanamycin and dihydrogeldanamycin derivatives

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12 December 2020

Cell transformation by the viral src oncogene

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12 December 2020

CDC37 is required for p60v-src activity in yeast

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12 December 2020

In vitro processing of recombinant G protein gamma subunits. Requirements for assembly of an active beta gamma complex

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12 December 2020

Destabilization of Raf-1 by geldanamycin leads to disruption of the Raf-1-MEK-mitogen-activated protein kinase signalling pathway

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12 December 2020

Molecular chaperones: biology and prospects for pharmacological intervention

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12 December 2020

Isolation of Hsp90 mutants by screening for decreased steroid receptor function

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12 December 2020

p185erbB2 binds to GRP94 in vivo. Dissociation of the p185erbB2/GRP94 heterocomplex by benzoquinone ansamycins precedes depletion of p185erbB2.

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12 December 2020

The complexity of Raf-1 regulation

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12 December 2020

Hop modulates Hsp70/Hsp90 interactions in protein folding

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12 December 2020

Analysis of native forms and isoform compositions of the mouse 90-kDa heat shock protein, HSP90

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12 December 2020

Two eukaryote-specific regions of Hsp82 are dispensable for its viability and signal transduction functions in yeast

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12 December 2020

Geldanamycin-induced destabilization of Raf-1 involves the proteasome

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12 December 2020

Benzoquinoid ansamycins (herbimycin A and geldanamycin) interfere with the maturation of growth factor receptor tyrosine kinases

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12 December 2020

Identifiers

DOI

10.1023/A:1006382320697

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Dimensions Publication ID

29 July 2017

1017271162

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