(Q33893719)

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Different catalytically competent arrangements of arachidonic acid within the cyclooxygenase active site of prostaglandin endoperoxide H synthase-1 lead to the formation of different oxygenated products

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scholarly article

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Europe PubMed Central

PubMed publication ID

29 July 2017

Different catalytically competent arrangements of arachidonic acid within the cyclooxygenase active site of prostaglandin endoperoxide H synthase-1 lead to the formation of different oxygenated products (English)

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

1 reference

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author name string

Thuresson ED

1

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Europe PubMed Central

PubMed publication ID

29 July 2017

Lakkides KM

2

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Europe PubMed Central

PubMed publication ID

29 July 2017

Smith WL

3

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Europe PubMed Central

PubMed publication ID

29 July 2017

language of work or name

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publication date

1 March 2000

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Europe PubMed Central

PubMed publication ID

29 July 2017

Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

29 July 2017

275

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Europe PubMed Central

PubMed publication ID

29 July 2017

12

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Europe PubMed Central

PubMed publication ID

29 July 2017

8501-8507

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Prostaglandin and thromboxane biosynthesis

1 reference

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21 January 2018

Prostaglandin endoperoxide H synthases (cyclooxygenases)-1 and -2

1 reference

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21 January 2018

Arachidonic acid oxygenation by COX-1 and COX-2. Mechanisms of catalysis and inhibition

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Interleukin-1 beta induces cytosolic phospholipase A2 and prostaglandin H synthase in rheumatoid synovial fibroblasts. Evidence for their roles in the production of prostaglandin E2.

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Differential expression of thromboxane A synthase and prostaglandin H synthase in megakaryocytic cell line

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Prostaglandin G/H synthase isoenzyme 2 expression in fibroblasts: regulation by dexamethasone, mitogens, and oncogenes

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21 January 2018

v-src induces prostaglandin synthase 2 gene expression by activation of the c-Jun N-terminal kinase and the c-Jun transcription factor

1 reference

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21 January 2018

Transcriptional regulation of prostaglandin synthase 2 gene expression by platelet-derived growth factor and serum

1 reference

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21 January 2018

Structure and function of a squalene cyclase

1 reference

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21 January 2018

The membrane association sequences of the prostaglandin endoperoxide synthases-1 and -2 isozymes

1 reference

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The membrane binding domains of prostaglandin endoperoxide H synthases 1 and 2. Peptide mapping and mutational analysis

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Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase

1 reference

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21 January 2018

Fatty acid substrate specificities of human prostaglandin-endoperoxide H synthase-1 and -2. Formation of 12-hydroxy-(9Z, 13E/Z, 15Z)- octadecatrienoic acids from alpha-linolenic acid

1 reference

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21 January 2018

Oxygen requirement for prostaglandin biosynthesis

1 reference

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21 January 2018

Spectroscopic evidence for reaction of prostaglandin H synthase-1 tyrosyl radical with arachidonic acid.

1 reference

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21 January 2018

Structural requirements for time-dependent inhibition of prostaglandin biosynthesis by anti-inflammatory drugs

1 reference

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21 January 2018

Prostaglandin H synthase: distinct binding sites for cyclooxygenase and peroxidase substrates

1 reference

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21 January 2018

Identification of novel arachidonic acid metabolites formed by prostaglandin H synthase

1 reference

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21 January 2018

Analysis of hydroperoxide-induced tyrosyl radicals and lipoxygenase activity in aspirin-treated human prostaglandin H synthase-2

1 reference

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21 January 2018

Subcellular localization of prostaglandin endoperoxide H synthases-1 and -2 by immunoelectron microscopy

1 reference

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21 January 2018

The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1

1 reference

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21 January 2018

Purification and characterisation of prostaglandin endoperoxide synthetase from sheep vesicular glands

1 reference

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21 January 2018

Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents

1 reference

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21 January 2018

Flexibility of the NSAID binding site in the structure of human cyclooxygenase-2

1 reference

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21 January 2018

Manganese lipoxygenase. Discovery of a bis-allylic hydroperoxide as product and intermediate in a lipoxygenase reaction.

1 reference

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21 January 2018

The structural basis of aspirin activity inferred from the crystal structure of inactivated prostaglandin H2 synthase

1 reference

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21 January 2018

Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system

1 reference

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21 January 2018

Affinities of various mammalian arachidonate lipoxygenases and cyclooxygenases for molecular oxygen as substrate

1 reference

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21 January 2018

Comparison of umbilical vein models for measurement of relative prostacyclin and thromboxane production

1 reference

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21 January 2018

Oxygenation of polyunsaturated fatty acids during prostaglandin biosynthesis by sheep vesicular gland

1 reference

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21 January 2018

The role of arginine 120 of human prostaglandin endoperoxide H synthase-2 in the interaction with fatty acid substrates and inhibitors

1 reference

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21 January 2018

Oxygenation of 5,8,11-eicosatrienoic acid by prostaglandin endoperoxide synthase and by cytochrome P450 monooxygenase: structure and mechanism of formation of major metabolites

1 reference

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21 January 2018

A test for the intermediacy of 11-hydroperoxyeicosa-5,8,12,14-tetraenoic acid [11-HPETE] in prostaglandin biosynthesis

1 reference

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21 January 2018

Stereospecificity of hydrogen abstraction in the conversion of arachidonic acid to 15R-HETE by aspirin-treated cyclooxygenase-2. Implications for the alignment of substrate in the active site

1 reference

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21 January 2018

Identifiers

10.1074/JBC.275.12.8501

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

ResearchGate publication ID

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