(Q33895804)

29 July 2017

1 reference

title

Safety and immunotoxicity assessment of immunomodulatory monoclonal antibodies (English)

1 reference

29 July 2017

1 reference

1 reference

Frank R Brennan

1

1 reference

29 July 2017

Laura Dill Morton

2

1 reference

29 July 2017

Sebastian Spindeldreher

3

1 reference

29 July 2017

Andrea Kiessling

4

1 reference

29 July 2017

Roy Allenspach

5

1 reference

29 July 2017

Adam Hey

6

1 reference

29 July 2017

Patrick Y Muller

7

1 reference

29 July 2017

Werner Frings

8

1 reference

29 July 2017

Jennifer Sims

9

1 reference

29 July 2017

publication date

23 May 2010

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29 July 2017

published in

Monoclonal Antibodies

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29 July 2017

volume

2

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29 July 2017

issue

3

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29 July 2017

page(s)

233-255

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Preclinical development of monoclonal antibodies: considerations for the use of non-human primates

29 July 2017

cites work

1 reference

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Immunotoxicity of monoclonal antibodies

5 July 2018

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Investigational immunotherapeutics for B-cell malignancies

5 July 2018

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Practical considerations for nonclinical safety evaluation of therapeutic monoclonal antibodies

5 July 2018

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Review of human DC subtypes

5 July 2018

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Therapeutic agents for patients with rheumatoid arthritis and an inadequate response to tumour necrosis factor-alpha antagonists

5 July 2018

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The status of biologic therapies in the treatment of moderate to severe psoriasis

5 July 2018

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The minimum anticipated biological effect level (MABEL) for selection of first human dose in clinical trials with monoclonal antibodies

5 July 2018

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Lupus-like syndrome attributable to anti-tumor necrosis factor alpha therapy in 14 patients during an 8-year period at Mayo Clinic

5 July 2018

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Novel targeted therapies for autoimmunity

5 July 2018

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The state of the art: immune-mediated mechanisms of monoclonal antibodies in cancer therapy

5 July 2018

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Toll-like receptors (TLRs) and Nod-like receptors (NLRs) in inflammatory disorders.

5 July 2018

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Progressive multifocal leukoencephalopathy in patients on immunomodulatory therapies

5 July 2018

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An interspecies comparison of placental antibody transfer: new insights into developmental toxicity testing of monoclonal antibodies

5 July 2018

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Risk of high-grade skin rash in cancer patients treated with cetuximab--an antibody against epidermal growth factor receptor: systemic review and meta-analysis

5 July 2018

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Therapeutic IgG4 antibodies engage in Fab-arm exchange with endogenous human IgG4 in vivo

5 July 2018

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Anti-CD40 agonist antibodies: preclinical and clinical experience

5 July 2018

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Essentials for starting a pediatric clinical study (3): Dynamic changes in early development of immune system in macaque monkeys--the significance from standpoint of preclinical toxicity test using nonhuman primates

5 July 2018

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The trifunctional antibody ertumaxomab destroys tumor cells that express low levels of human epidermal growth factor receptor 2.

5 July 2018

1 reference

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Monoclonal antibodies in the therapy of multiple sclerosis: an overview

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881251

Safety assessment and dose selection for first-in-human clinical trials with immunomodulatory monoclonal antibodies

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881251

Use of pharmacokinetic/ pharmacodynamic modelling for starting dose selection in first-in-human trials of high-risk biologics

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881251

New approaches to prediction of immune responses to therapeutic proteins during preclinical development

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881251

Structural characterization of a human Fc fragment engineered for lack of effector functions

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881251

NK cell tolerance and the maternal-fetal interface

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881251

What's so special about the developing immune system?

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881251

Testing human biologicals in animal host resistance models

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881251

Monoclonal antibody first dose cytokine release syndromes-mechanisms and prediction

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881251

Cetuximab-induced anaphylaxis and IgE specific for galactose-alpha-1,3-galactose

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881251

Recommendations on risk-based strategies for detection and characterization of antibodies against biotechnology products

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881251

Fcgamma receptors as regulators of immune responses

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881251

Ipilimumab (anti-CTLA4 antibody) causes regression of metastatic renal cell cancer associated with enteritis and hypophysitis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881251

The role of the CTLA4 blockade in the treatment of malignant melanoma

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881251

On the anticipation of the human dose in first-in-man trials from preclinical and prior clinical information in early drug development

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881251

Eculizumab: A novel therapy for paroxysmal nocturnal hemoglobinuria

5 July 2018

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Antibody therapeutics: isotype and glycoform selection

5 July 2018

1 reference

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FcRn: the neonatal Fc receptor comes of age.

5 July 2018

1 reference

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Antigen-presenting cells and materno-fetal tolerance: an emerging role for dendritic cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881251

Alemtuzumab in chronic lymphocytic leukemia

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881251

Immunostimulatory monoclonal antibodies for cancer therapy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881251

Influenza virus host resistance model

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881251

Bacterial host resistance models in the evaluation of immunotoxicity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881251

B-cell-targeted therapy for systemic lupus erythematosus

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881251

Natalizumab and progressive multifocal leucoencephalopathy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881251

Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881251

Loss of Siglec expression on T lymphocytes during human evolution

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881251

Biologic therapies in clinical development for the treatment of rheumatoid arthritis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881251

Structural characterization and immunogenicity in wild-type and immune tolerant mice of degraded recombinant human interferon alpha2b.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881251

Tolerability and safety of rituximab (MabThera).

5 July 2018

1 reference

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Siglecs in innate immunity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881251

Generating quantitative models describing the sequence specificity of biological processes with the stabilized matrix method

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881251

The accuracy of extended histopathology to detect immunotoxic chemicals

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881251

The linkage of innate to adaptive immunity via maturing dendritic cells in vivo requires CD40 ligation in addition to antigen presentation and CD80/86 costimulation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881251

Forecasting the cytokine storm following systemic interleukin (IL)-2 administration

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881251

Efficacy and safety of adalimumab as monotherapy in patients with rheumatoid arthritis for whom previous disease modifying antirheumatic drug treatment has failed

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881251

Species differences in the structure and function of the immune system

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881251

Immunological relationship between the mother and the fetus

5 July 2018

1 reference

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Adalimumab, a fully human anti-tumor necrosis factor alpha monoclonal antibody, for the treatment of rheumatoid arthritis in patients taking concomitant methotrexate: the ARMADA trial

5 July 2018

1 reference

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NOD/SCID/gamma(c)(null) mouse: an excellent recipient mouse model for engraftment of human cells

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881251

Antigen-antibody immune complexes empower dendritic cells to efficiently prime specific CD8+ CTL responses in vivo

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881251

Pure red-cell aplasia and antierythropoietin antibodies in patients treated with recombinant erythropoietin

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881251

Thrombocytopenia caused by the development of antibodies to thrombopoietin

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881251

Preclinical development of keliximab, a Primatized anti-CD4 monoclonal antibody, in human CD4 transgenic mice: characterization of the model and safety studies.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881251

Histopathologic approaches to detect changes indicative of immunotoxicity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881251

A humanized anti-CD3 antibody, HuM291, with low mitogenic activity, mediates complete and reversible T-cell depletion in chimpanzees

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881251

Differential processing of influenza nucleoprotein in human and mouse cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881251

Peripheral blood CD4+CD8+ lymphocytes in cynomolgus monkeys are of resting memory T lineage.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881251

An HLA-DR1 transgene confers susceptibility to collagen-induced arthritis elicited with human type II collagen.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881251

Risk assessment in immunotoxicology. II. Relationships between immune and host resistance tests

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881251

Integrated studies of biology: multiplexed imaging assays from molecules to man and back

5 July 2018

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https://api.crossref.org/works/10.4161%2FMABS.2.3.11782

Triggering of OX40 (CD134) on CD4(+)CD25+ T cells blocks their inhibitory activity: a novel regulatory role for OX40 and its comparison with GITR.

21 January 2018

1 reference

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Adverse consequences of immunostimulation

21 January 2018

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Progressive multifocal leukoencephalopathy after natalizumab monotherapy.

21 January 2018

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https://api.crossref.org/works/10.4161%2FMABS.2.3.11782

Immune surveillance in multiple sclerosis patients treated with natalizumab.

21 January 2018

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https://api.crossref.org/works/10.4161%2FMABS.2.3.11782

Specificity and affinity of human Fcgamma receptors and their polymorphic variants for human IgG subclasses.

21 January 2018

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https://api.crossref.org/works/10.4161%2FMABS.2.3.11782

Whole blood cytokine response as a measure of immunotoxicity.

21 January 2018

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https://api.crossref.org/works/10.4161%2FMABS.2.3.11782

Evaluation of the immuno-stimulatory potential of stopper extractables and leachables by using dendritic cells as readout.

21 January 2018

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https://api.crossref.org/works/10.4161%2FMABS.2.3.11782

Development of a human adaptive immune system in cord blood cell-transplanted mice

21 January 2018

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https://api.crossref.org/works/10.4161%2FMABS.2.3.11782

Improved prediction of MHC class I and class II epitopes using a novel Gibbs sampling approach.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FMABS.2.3.11782

Evaluation of a surrogate antibody for preclinical safety testing of an anti-CD11a monoclonal antibody

21 January 2018

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https://api.crossref.org/works/10.4161%2FMABS.2.3.11782

Immunotoxicity evaluation by immune function tests: focus on the T-dependent antibody response (TDAR) [Overview of a Workshop Session at the 45th Annual Meeting of the Society of Toxicology (SOT) March 5-9, 2006 San Diego, CA].

21 January 2018

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Developmental toxicity testing of monoclonal antibodies: an enhanced pre- and postnatal study design option

21 January 2018

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https://api.crossref.org/works/10.4161%2FMABS.2.3.11782

Developmental immunotoxicology (DIT): windows of vulnerability, immune dysfunction and safety assessment.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FMABS.2.3.11782

TGF-beta 1 prevents the noncognate maturation of human dendritic Langerhans cells

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881251

Generation of tissue-specific and promiscuous HLA ligand databases using DNA microarrays and virtual HLA class II matrices

29 October 2018

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https://api.crossref.org/works/10.4161%2FMABS.2.3.11782

Pulsed monoclonal antibody treatment and autoimmune thyroid disease in multiple sclerosis

21 January 2018

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12 December 2020

Triggering of T cell proliferation through CD28 induces GATA-3 and promotes T helper type 2 differentiation in vitro and in vivo

1 reference

12 December 2020

Using an analogous monoclonal antibody to evaluate the reproductive and chronic toxicity potential for a humanized anti-TNFalpha monoclonal antibody

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12 December 2020

Anchor profiles of HLA-specific peptides: analysis by a novel affinity scoring method and experimental validation

1 reference

12 December 2020

STP position paper: best practice guideline for the routine pathology evaluation of the immune system

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12 December 2020

Infections Associated with Tumor Necrosis Factor-α Antagonists

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12 December 2020

IgG Fc receptor III homologues in nonhuman primate species: genetic characterization and ligand interactions

1 reference

12 December 2020

Effects of an anti-TNF-alpha monoclonal antibody, administered throughout pregnancy and lactation, on the development of the macaque immune system

1 reference

12 December 2020

"Cytokine storm" in the phase I trial of monoclonal antibody TGN1412: better understanding the causes to improve preclinical testing of immunotherapeutics

1 reference

12 December 2020

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12 December 2020

Recombinant antibodies for cancer therapy

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12 December 2020

Trastuzumab cardiotoxicity: biological hypotheses and clinical open issues

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12 December 2020

Clinical immunotoxicity of therapeutic proteins

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12 December 2020

Commentary on the EMA Guideline on strategies to identify and mitigate risks for first-in-human and early clinical trials with investigational medicinal products (EMEA/CHMP/SWP/28367/07 Rev. 1.

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12 December 2020

A vector driving the expression of foreign cDNAs in the MHC class II-positive cells of transgenic mice

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12 December 2020

Negative and positive selection by HLA-DR3(DRw17) molecules in transgenic mice

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12 December 2020

Human leukocyte antigen-DRB1*1502 (DR2Dw12) transgene reduces incidence and severity of arthritis in mice

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12 December 2020

Points to consider in the manufacture and testing of monoclonal antibody products for human use (1997). U.S. Food and Drug Administration Center for Biologics Evaluation and Research

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12 December 2020

Identifiers

DOI

10.4161/MABS.2.3.11782

1 reference

29 July 2017

1 reference

29 July 2017

1 reference