(Q36985094)

17 August 2017

1 reference

title

On the anticipation of the human dose in first-in-man trials from preclinical and prior clinical information in early drug development (English)

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17 August 2017

Lowe PJ

1

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17 August 2017

Hijazi Y

2

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17 August 2017

Luttringer O

3

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17 August 2017

Yin H

4

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17 August 2017

Sarangapani R

5

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17 August 2017

Howard D

6

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17 August 2017

language of work or name

English

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publication date

1 October 2007

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17 August 2017

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17 August 2017

volume

37

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17 August 2017

issue

10-11

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17 August 2017

page(s)

1331-1354

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Prospective allometric scaling: does the emperor have clothes?

17 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1080%2F00498250701648008

Interspecies variation in liver weight, hepatic blood flow, and antipyrine intrinsic clearance: Extrapolation of data to benzodiazepines and phenytoin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701648008

Interspecies scaling, allometry, physiological time, and the ground plan of pharmacokinetics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701648008

Down-regulation of CD28 expression by TNF-alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701648008

Why is it challenging to predict intestinal drug absorption and oral bioavailability in human using rat model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701648008

Modeling of pharmacokinetic/pharmacodynamic (PK/PD) relationships: concepts and perspectives

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701648008

In vitro-in vivo correlation of hepatobiliary drug clearance in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701648008

Kinetics of pharmacologic response

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701648008

Prediction of human drug clearance from in vitro and preclinical data using physiologically based and empirical approaches

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701648008

Finally! The Brambell receptor (FcRB). Mediator of transmission of immunity and protection from catabolism for IgG.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701648008

Dihydropyrimidine dehydrogenase inactivation and 5-fluorouracil pharmacokinetics: allometric scaling of animal data, pharmacokinetics and toxicodynamics of 5-fluorouracil in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701648008

Prediction of hepatic metabolic clearance based on interspecies allometric scaling techniques and in vitro-in vivo correlations

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701648008

Integration of in vitro data into allometric scaling to predict hepatic metabolic clearance in man: application to 10 extensively metabolized drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701648008

Role of P-glycoprotein in pharmacokinetics: clinical implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701648008

Antibody pharmacokinetics and pharmacodynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701648008

Physiologically Based Pharmacokinetic (PBPK) Modeling of Disposition of Epiroprim in Humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701648008

General pharmacokinetic model for drugs exhibiting target-mediated drug disposition

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701648008

Integration of in vitro data and brain weight in allometric scaling to predict clearance in humans: some suggestions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701648008

Interspecies scaling: predicting oral clearance in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701648008

Interspecies scaling: predicting clearance of drugs in humans. Three different approaches

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701648008

The pharmacokinetic principles behind scaling from preclinical results to phase I protocols

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701648008

Interspecies scaling of biliary excreted drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701648008

On the prediction of the human response: a recycled mechanistic pharmacokinetic/pharmacodynamic approach.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701648008

Asymmetric intestinal first-pass metabolism causes minimal oral bioavailability of midazolam in cynomolgus monkey

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701648008

Prediction of intestinal absorption: comparative assessment of GASTROPLUS and IDEA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701648008

Prediction of pharmacokinetics prior to in vivo studies. 1. Mechanism-based prediction of volume of distribution.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701648008

Prediction of pharmacokinetics prior to in vivo studies. II. Generic physiologically based pharmacokinetic models of drug disposition

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701648008

Estimating the starting dose for entry into humans: principles and practice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701648008

Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701648008

Simulation and prediction of in vivo drug metabolism in human populations from in vitro data

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701648008

Route-specific differences in distribution characteristics of octamethylcyclotetrasiloxane in rats: analysis using PBPK models

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701648008

Prediction of metabolic drug clearance in humans: in vitro-in vivo extrapolation vs allometric scaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701648008

A mathematical description of the functionality of correction factors used in allometry for predicting human drug clearance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701648008

From physicochemistry to absorption and distribution: predictive mechanistic modelling and computational tools

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701648008

Misuse of the well-stirred model of hepatic drug clearance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701648008

In vitro and in vivo models for assessing drug efflux transporter activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701648008

10.1080/00498250701648008

21 January 2018

Identifiers

DOI

1 reference

17 August 2017

1 reference