(Q30984976)

28 June 2017

title

Prediction of human drug clearance from in vitro and preclinical data using physiologically based and empirical approaches (English)

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28 June 2017

Kiyomi Ito

1

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28 June 2017

J Brian Houston

series ordinal

2

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28 June 2017

publication date

1 January 2005

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28 June 2017

published in

Pharmaceutical Research

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28 June 2017

volume

22

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28 June 2017

issue

1

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28 June 2017

page(s)

103-112

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The potential pharmacological and toxicological impact of P450 screening

28 June 2017

cites work

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12 December 2020

Determination of hepatic blood flow in the rat using sequential infusions of indocyanine green or galactose

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Antipyrine as a probe for human oxidative drug metabolism: Identification of the cytochrome P450 enzymes catalyzing 4-hydroxyantipyrine, 3-hydroxymethylantipyrine, and norantipyrine formation*

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In vitro analysis of human drug glucuronidation and prediction of in vivo metabolic clearance

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Stereoselective metabolism of felodipine in liver microsomes from rat, dog, and human.

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In vitro-in vivo scaling of CYP kinetic data not consistent with the classical Michaelis-Menten model

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Interspecies scaling: predicting clearance of drugs in humans. Three different approaches

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12 December 2020

Comparison of the use of liver models for predicting drug clearance using in vitro kinetic data from hepatic microsomes and isolated hepatocytes

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12 December 2020

Prediction of pharmacokinetics prior to in vivo studies. II. Generic physiologically based pharmacokinetic models of drug disposition

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Propranolol oxidation by human liver microsomes--the use of cumene hydroperoxide to probe isoenzyme specificity and regio- and stereoselectivity

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Characterization of human small intestinal cytochromes P-450.

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Regional drug delivery II: relationship between drug targeting index and pharmacokinetic parameters for three non-steroidal anti-inflammatory drugs using the rat air pouch model of inflammation.

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Methotrexate Pharmacokinetics

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12 December 2020

Interspecies scaling, allometry, physiological time, and the ground plan of pharmacokinetics.

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12 December 2020

Prediction of in vivo drug metabolism in the human liver from in vitro metabolism data

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12 December 2020

Disposition of indinavir, a potent HIV-1 protease inhibitor, after an oral dose in humans

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12 December 2020

Prediction of human clearance of twenty-nine drugs from hepatic microsomal intrinsic clearance data: An examination of in vitro half-life approach and nonspecific binding to microsomes.

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Induction of propranolol metabolism by the azo dye sudan III in rats

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Interspecies metabolism and pharmacokinetic scaling of theophylline disposition

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Multiple forms of cytochrome P450 are involved in the metabolism of ondansetron in humans

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12 December 2020

Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance

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12 December 2020

Complications in the estimation of hepatic blood flow in vivo by pharmacokinetic parameters. The area under the curve after the concomitant intravenous and intraperitoneal (or intraportal) administration of acetaminophen in the rat

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12 December 2020

Determination of P4501A2 activity in human liver microsomes using [3-14C-methyl]caffeine

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12 December 2020

Hepatic clearance of drugs. I. Theoretical considerations of a "well-stirred" model and a "parallel tube" model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance

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12 December 2020

Some suggestions for measuring predictive performance

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12 December 2020

Correlation of plasma clearance of 54 extensively metabolized drugs between humans and rats: mean allometric coefficient of 0.66.

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12 December 2020

The prediction of human pharmacokinetic parameters from preclinical and in vitro metabolism data.

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12 December 2020

Characterization of interintestinal and intraintestinal variations in human CYP3A-dependent metabolism.

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Identification of 2,6-xylidine as a major lidocaine metabolite in human liver slices.

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12 December 2020

Prediction of hepatic metabolic clearance: comparison and assessment of prediction models

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12 December 2020

Microsomal prediction of in vivo clearance of CYP2C9 substrates in humans

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12 December 2020

Species differences in the pharmacokinetics and metabolism of indinavir, a potent human immunodeficiency virus protease inhibitor.

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12 December 2020

Prediction of species differences (rats, dogs, humans) in the in vivo metabolic clearance of YM796 by the liver from in vitro data.

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12 December 2020

Is the role of the small intestine in first-pass metabolism overemphasized?

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12 December 2020

A carrier-protein receptor is not a prerequisite for avid hepatic elimination of highly bound compounds: a study of propranolol elimination by the isolated perfused rat liver

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12 December 2020

Prediction of hepatic clearance from microsomes, hepatocytes, and liver slices

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12 December 2020

Hepatic and intestinal metabolism of indinavir, an HIV protease inhibitor, in rat and human microsomes. Major role of CYP3A

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12 December 2020

Prediction of human hepatic clearance from in vivo animal experiments and in vitro metabolic studies with liver microsomes from animals and humans.

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12 December 2020

Integration of in vitro data into allometric scaling to predict hepatic metabolic clearance in man: application to 10 extensively metabolized drugs

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12 December 2020

10.1007/S11095-004-9015-1

Identifiers

DOI

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release_6v5bx6jppjc5bpde6vzdioiyua

28 June 2017

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/6v5bx6jppjc5bpde6vzdioiyua

24 November 2022

mapped directly with Wikidata item

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