(Q60787070)

English

Antipyrine as a probe for human oxidative drug metabolism: Identification of the cytochrome P450 enzymes catalyzing 4-hydroxyantipyrine, 3-hydroxymethylantipyrine, and norantipyrine formation*

scientific article published on 01 June 1996

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16 October 2019

Antipyrine as a probe for human oxidative drug metabolism: identification of the cytochrome P450 enzymes catalyzing 4-hydroxyantipyrine, 3-hydroxymethylantipyrine, and norantipyrine formation (English)

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16 October 2019

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16 October 2019

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Engel G

1

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16 October 2019

Heidemann H

3

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16 October 2019

Cosme J

4

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16 October 2019

Eichelbaum M

5

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16 October 2019

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1 June 1996

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16 October 2019

Clinical Pharmacology & Therapeutics

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16 October 2019

59

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16 October 2019

6

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16 October 2019

613-623

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16 October 2019

The role of individual human cytochromes P450 in drug metabolism and clinical response

1 reference

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7 January 2021

Role of human hepatic cytochromes P450 in drug metabolism and toxicity

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Assessment of the drug metabolism capacity of the liver

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The model drug approach in clinical pharmacology

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The antipyrine test in clinical pharmacology: Conceptions and misconceptions

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Drugs and the liver. Part II. The role of the antipyrine test in drug metabolism studies

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Antipyrine metabolism in relation to polymorphic oxidations of sparteine and debrisoquine

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Antipyrine clearance and metabolite formation in patients with alcoholic cirrhosis

1 reference

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Metabolism of drugs. LIX. A new metabolite of antipyrine.

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7 January 2021

The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature

1 reference

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7 January 2021

A 'cocktail' strategy to assess in vivo oxidative drug metabolism in humans

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7 January 2021

Highly sensitive and specific gas chromatographic-tandem mass spectrometric method for the determination of trace amounts of antipyrine metabolites in biological material

1 reference

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7 January 2021

Patients with type II autoimmune hepatitis express functionally intact cytochrome P-450 db1 that is inhibited by LKM-1 autoantibodies in vitro but not in vivo

1 reference

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7 January 2021

Human anti-endoplasmic reticulum autoantibodies appearing in a drug-induced hepatitis are directed against a human liver cytochrome P-450 that hydroxylates the drug

1 reference

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7 January 2021

Genetic polymorphism of human cytochrome P-450 (S)-mephenytoin 4-hydroxylase. Studies with human autoantibodies suggest a functionally altered cytochrome P-450 isozyme as cause of the genetic deficiency

1 reference

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7 January 2021

Purification and characterization of liver microsomal cytochromes p-450: electrophoretic, spectral, catalytic, and immunochemical properties and inducibility of eight isozymes isolated from rats treated with phenobarbital or beta-naphthoflavone

1 reference

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7 January 2021

Furafylline is a potent and selective inhibitor of cytochrome P450IA2 in man.

1 reference

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7 January 2021

Fluvoxamine is a potent inhibitor of cytochrome P4501A2

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7 January 2021

In vitro inhibition studies of tolbutamide hydroxylase activity of human liver microsomes by azoles, sulphonamides and quinolines

1 reference

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7 January 2021

Effects of imidazole derivatives on cytochromes P450 from human hepatocytes in primary culture

1 reference

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7 January 2021

Effects of ketoconazole on the polymorphic 4-hydroxylations of S-mephenytoin and debrisoquine

1 reference

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7 January 2021

Comparative effects of two antimycotic agents, ketoconazole and terbinafine on the metabolism of tolbutamide, ethinyloestradiol, cyclosporin and ethoxycoumarin by human liver microsomes in vitro

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7 January 2021

Saccharomyces cerevisiae: an alternative source for human microsomal liver enzymes and its use in drug interaction studies

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7 January 2021

Evidence that CYP2C19 is the major (S)-mephenytoin 4'-hydroxylase in humans

1 reference

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7 January 2021

Isolation and characterization of human liver cytochrome P450 2C19: correlation between 2C19 and S-mephenytoin 4'-hydroxylation

1 reference

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7 January 2021

Engineered yeast cells as model to study coupling between human xenobiotic metabolizing enzymes. Simulation of the two first steps of benzo[a]pyrene activation

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7 January 2021

Synthesis of functional mouse cytochromes P-450 P1 and chimeric P-450 P3-1 in the yeast Saccharomyces cerevisiae.

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7 January 2021

Relationship between the metabolism of antipyrine, hexobarbitone and theophylline in man as assessed by a 'cocktail' approach

1 reference

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7 January 2021

Studies of the different metabolic pathways of antipyrine in man. Oral versus i.v. administration and the influence of urinary collection time

1 reference

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7 January 2021

A radiometric high-pressure liquid chromatography assay for the simultaneous determination of the three main oxidative metabolites of antipyrine in studies in vitro

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7 January 2021

Immunotoxicology and expression of human cytochrome P450 in microorganisms

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Differential induction of antipyrine metabolism by rifampicin.

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Influence of rifampicin treatment on antipyrine clearance and metabolite formation in patients with tuberculosis

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Identifiers

10.1016/S0009-9236(96)90001-6

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8681486%20AND%20SRC:MED&resulttype=core&format=json

16 October 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8681486%20AND%20SRC:MED&resulttype=core&format=json

16 October 2019

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