(Q33899444)

29 July 2017

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title

The Werner syndrome gene: the molecular basis of RecQ helicase-deficiency diseases (English)

1 reference

29 July 2017

1 reference

J C Shen

1

1 reference

PubMed ID

10782115

29 July 2017

L A Loeb

series ordinal

2

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29 July 2017

1 May 2000

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29 July 2017

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29 July 2017

16

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29 July 2017

213-220

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29 July 2017

5

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Werner's syndrome: a review of recent research with an analysis of connective tissue metabolism, growth control of cultured cells, and chromosomal aberrations

29 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901970-8

7 January 2021

Impaired S-phase transit of Werner syndrome cells expressed in lymphoblastoid cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901970-8

7 January 2021

Cytogenetics of Werner's syndrome cultured skin fibroblasts: variegated translocation mosaicism

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901970-8

7 January 2021

Mutator phenotype of Werner syndrome is characterized by extensive deletions

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901970-8

7 January 2021

Positional cloning of the Werner's syndrome gene

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901970-8

7 January 2021

The Werner syndrome protein is a DNA helicase

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901970-8

7 January 2021

DNA helicase activity in Werner's syndrome gene product synthesized in a baculovirus system

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901970-8

7 January 2021

Characterization of Werner syndrome protein DNA helicase activity: directionality, substrate dependence and stimulation by replication protein A

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901970-8

7 January 2021

Functional and physical interaction between WRN helicase and human replication protein A

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901970-8

7 January 2021

Human werner syndrome DNA helicase unwinds tetrahelical structures of the fragile X syndrome repeat sequence d(CGG)n

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901970-8

7 January 2021

The premature ageing syndrome protein, WRN, is a 3'-->5' exonuclease

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901970-8

7 January 2021

Werner syndrome protein. I. DNA helicase and dna exonuclease reside on the same polypeptide.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901970-8

7 January 2021

Werner syndrome protein. II. Characterization of the integral 3' --> 5' DNA exonuclease

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901970-8

7 January 2021

Werner syndrome helicase contains a 5'-->3' exonuclease activity that digests DNA and RNA strands in DNA/DNA and RNA/DNA duplexes dependent on unwinding

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901970-8

7 January 2021

Enzymatic and DNA binding properties of purified WRN protein: high affinity binding to single-stranded DNA but not to DNA damage induced by 4NQO.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901970-8

7 January 2021

The Werner syndrome protein is involved in RNA polymerase II transcription

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901970-8

7 January 2021

A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901970-8

7 January 2021

Genetic linkage of Werner's syndrome to five markers on chromosome 8

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901970-8

7 January 2021

The Bloom's syndrome gene product is homologous to RecQ helicases

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901970-8

7 January 2021

Mutations in RECQL4 cause a subset of cases of Rothmund-Thomson syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901970-8

7 January 2021

The Saccharomyces cerevisiae Sgs1 helicase efficiently unwinds G-G paired DNAs

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901970-8

7 January 2021

The Bloom's syndrome helicase unwinds G4 DNA

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901970-8

7 January 2021

RecQ DNA helicase is a suppressor of illegitimate recombination in Escherichia coli

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901970-8

7 January 2021

RecQ helicase, in concert with RecA and SSB proteins, initiates and disrupts DNA recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901970-8

7 January 2021

Bloom's and Werner's syndrome genes suppress hyperrecombination in yeast sgs1 mutant: implication for genomic instability in human diseases

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901970-8

7 January 2021

recF and recR are required for the resumption of replication at DNA replication forks in Escherichia coli

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901970-8

7 January 2021

RecQ and RecJ process blocked replication forks prior to the resumption of replication in UV-irradiated Escherichia coli

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901970-8

7 January 2021

Abnormal fibroblast aging and DNA replication in the Werner syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901970-8

7 January 2021

Autoradiographic studies of DNA replication in Werner's syndrome cells

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901970-8

7 January 2021

The FEN-1 family of structure-specific nucleases in eukaryotic DNA replication, recombination and repair

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901970-8

7 January 2021

Is RecF a DNA replication protein?

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901970-8

7 January 2021

Recombinational crossroads: eukaryotic enzymes and the limits of bacterial precedents

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901970-8

7 January 2021

A broadening view of recombinational DNA repair in bacteria.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901970-8

7 January 2021

Instability of inhibited replication forks in E. coli.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901970-8

7 January 2021

FFA-1, a protein that promotes the formation of replication centers within nuclei

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901970-8

7 January 2021

Replication focus-forming activity 1 and the Werner syndrome gene product

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901970-8

7 January 2021

Bloom's syndrome protein, BLM, colocalizes with replication protein A in meiotic prophase nuclei of mammalian spermatocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901970-8

7 January 2021

Replication protein A: a heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901970-8

7 January 2021

p53 modulation of TFIIH-associated nucleotide excision repair activity

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901970-8

7 January 2021

p53-mediated apoptosis is attenuated in Werner syndrome cells

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901970-8

7 January 2021

Physical and functional interaction between p53 and the Werner's syndrome protein

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901970-8

7 January 2021

The yeast type I topoisomerase Top3 interacts with Sgs1, a DNA helicase homolog: a potential eukaryotic reverse gyrase

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901970-8

7 January 2021

Sgs1: a eukaryotic homolog of E. coli RecQ that interacts with topoisomerase II in vivo and is required for faithful chromosome segregation

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901970-8

7 January 2021

Werner syndrome lymphoblastoid cells are sensitive to camptothecin-induced apoptosis in S-phase

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901970-8

7 January 2021

RecQ helicase and topoisomerase III comprise a novel DNA strand passage function: a conserved mechanism for control of DNA recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901970-8

7 January 2021

Positionally cloned human disease genes: patterns of evolutionary conservation and functional motifs

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901970-8

7 January 2021

The proofreading domain of Escherichia coli DNA polymerase I and other DNA and/or RNA exonuclease domains

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901970-8

7 January 2021

The three faces of the WS helicase.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901970-8

7 January 2021

Mutation and haplotype analyses of the Werner's syndrome gene based on its genomic structure: genetic epidemiology in the Japanese population

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901970-8

7 January 2021

Impaired nuclear localization of defective DNA helicases in Werner's syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901970-8

7 January 2021

An apoptosis-inducing genotoxin differentiates heterozygotic carriers for Werner helicase mutations from wild-type and homozygous mutants

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901970-8

7 January 2021

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901970-8

1 reference

7 January 2021

Life without DNA repair

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901970-8

7 January 2021

Site-specific DNA damage and 8-hydroxydeoxyguanosine formation by hydroxylamine and 4-hydroxyaminoquinoline 1-oxide in the presence of Cu(II): role of active oxygen species.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901970-8

7 January 2021

Cloning of a mouse homologue of the human Werner syndrome gene and assignment to 8A4 by fluorescence in situ hybridization.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901970-8

7 January 2021

Nucleolar localization of the Werner syndrome protein in human cells

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901970-8

7 January 2021

Oligomeric ring structure of the Bloom's syndrome helicase

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901970-8

7 January 2021

Molecular cloning of cDNA encoding human DNA helicase Q1 which has homology to Escherichia coli Rec Q helicase and localization of the gene at chromosome 12p12

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901970-8

7 January 2021

Cloning of two new human helicase genes of the RecQ family: biological significance of multiple species in higher eukaryotes

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901970-8

7 January 2021

rqh1+, a fission yeast gene related to the Bloom's and Werner's syndrome genes, is required for reversible S phase arrest

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901970-8

7 January 2021

The recQ gene of Escherichia coli K12: molecular cloning and isolation of insertion mutants

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901970-8

7 January 2021

Defending genome integrity during DNA replication: a proposed role for RecQ family helicases

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901970-8

7 January 2021

Binding specificity determines polarity of DNA unwinding by the Sgs1 protein of S. cerevisiae.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901970-8

7 January 2021

A retarded rate of DNA replication and normal level of DNA repair in Werner's syndrome fibroblasts in culture

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901970-8

7 January 2021

Spontaneous and induced chromosomal instability in Werner syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901970-8

7 January 2021

Differential effects of cytotoxic drugs on mortal and immortalized B-lymphoblastoid cell lines from normal and Werner's syndrome patients

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2899%2901970-8

7 January 2021

10.1016/S0168-9525(99)01970-8

Identifiers

DOI

1 reference

29 July 2017

1 reference

PubMed ID

10782115