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Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2
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Europe PubMed Central
PMC publication ID
1177374
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16006525%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 December 2019
title
Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
1177374
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16006525%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 December 2019
author
Richard van Breemen
series ordinal
4
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Europe PubMed Central
PMC publication ID
1177374
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16006525%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 December 2019
Andrew D. Mesecar
series ordinal
5
1 reference
stated in
Europe PubMed Central
PMC publication ID
1177374
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16006525%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 December 2019
John M Pezzuto
series ordinal
3
object named as
John M Pezzuto
1 reference
stated in
Europe PubMed Central
PMC publication ID
1177374
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16006525%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 December 2019
author name string
Aimee L Eggler
series ordinal
1
1 reference
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Europe PubMed Central
PMC publication ID
1177374
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16006525%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 December 2019
Guowen Liu
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMC publication ID
1177374
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16006525%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 December 2019
language of work or name
English
0 references
publication date
8 July 2005
1 reference
stated in
Europe PubMed Central
PMC publication ID
1177374
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16006525%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 December 2019
published in
Proceedings of the National Academy of Sciences of the United States of America
1 reference
stated in
Europe PubMed Central
PMC publication ID
1177374
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16006525%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 December 2019
volume
102
1 reference
stated in
Europe PubMed Central
PMC publication ID
1177374
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16006525%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 December 2019
issue
29
1 reference
stated in
Europe PubMed Central
PMC publication ID
1177374
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16006525%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 December 2019
page(s)
10070-10075
1 reference
stated in
Europe PubMed Central
PMC publication ID
1177374
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16006525%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 December 2019
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Molecular mechanisms activating the Nrf2-Keap1 pathway of antioxidant gene regulation
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PubMed Central
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Nuclear oncoprotein prothymosin alpha is a partner of Keap1: implications for expression of oxidative stress-protecting genes.
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BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase
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Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex
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Fetal Alz-50 clone 1 interacts with the human orthologue of the Kelch-like Ech-associated protein
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The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase
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NADPH oxidase and ERK signaling regulates hyperoxia-induced Nrf2-ARE transcriptional response in pulmonary epithelial cells
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Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2
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Cullin-based ubiquitin ligases: Cul3-BTB complexes join the family.
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Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers
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5 July 2018
Transcription factor Nrf2 regulates inflammation by mediating the effect of 15-deoxy-Delta(12,14)-prostaglandin j(2)
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Cellular mechanisms of redox cell signalling: role of cysteine modification in controlling antioxidant defences in response to electrophilic lipid oxidation products
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Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress
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5 July 2018
Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation
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Importance of phase 2 gene regulation in protection against electrophile and reactive oxygen toxicity and carcinogenesis
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Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression
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5 July 2018
Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants
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5 July 2018
Identification of the interactive interface and phylogenic conservation of the Nrf2-Keap1 system.
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5 July 2018
The Keap1 BTB/POZ dimerization function is required to sequester Nrf2 in cytoplasm
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PubMed Central
reference URL
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5 July 2018
Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex
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Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice
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5 July 2018
Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages
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Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
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Identification of a common chemical signal regulating the induction of enzymes that protect against chemical carcinogenesis
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The potency of inducers of NAD(P)H:(quinone-acceptor) oxidoreductase parallels their efficiency as substrates for glutathione transferases. Structural and electronic correlations
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Deletion of DnaK's lid strengthens binding to the nucleotide exchange factor, GrpE: a kinetic and thermodynamic analysis
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Characterization of interactions between the anti-apoptotic protein BAG-1 and Hsc70 molecular chaperones
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Identifiers
DOI
10.1073/PNAS.0502402102
1 reference
stated in
Europe PubMed Central
PMC publication ID
1177374
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16006525%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 December 2019
ADS bibcode
2005PNAS..10210070E
0 references
PMC publication ID
1177374
1 reference
stated in
Europe PubMed Central
PMC publication ID
1177374
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16006525%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 December 2019
PubMed publication ID
16006525
1 reference
stated in
Europe PubMed Central
PMC publication ID
1177374
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16006525%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 December 2019
ResearchGate publication ID
7737092
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