(Q33900787)

English

Adamantyl-substituted retinoid-derived molecules that interact with the orphan nuclear receptor small heterodimer partner: effects of replacing the 1-adamantyl or hydroxyl group on inhibition of cancer cell growth, induction of cancer cell apoptosis

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Europe PubMed Central

PubMed publication ID

29 July 2017

Adamantyl-substituted retinoid-derived molecules that interact with the orphan nuclear receptor small heterodimer partner: effects of replacing the 1-adamantyl or hydroxyl group on inhibition of cancer cell growth, induction of cancer cell apoptosis (English)

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Europe PubMed Central

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29 July 2017

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author name string

Marcia I Dawson

1

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Europe PubMed Central

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29 July 2017

Zebin Xia

2

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29 July 2017

Tao Jiang

3

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29 July 2017

Mao Ye

4

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29 July 2017

Joseph A Fontana

5

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Europe PubMed Central

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29 July 2017

Lulu Farhana

6

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29 July 2017

Bhaumik Patel

7

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29 July 2017

Li Ping Xue

8

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29 July 2017

Mohammad Bhuiyan

9

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29 July 2017

Roberto Pellicciari

10

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29 July 2017

Antonio Macchiarulo

11

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29 July 2017

Roberto Nuti

12

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29 July 2017

Xiao-Kun Zhang

13

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29 July 2017

Young-Hoon Han

14

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29 July 2017

Lutz Tautz

15

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29 July 2017

Peter D Hobbs

16

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29 July 2017

Ling Jong

17

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29 July 2017

Nahid Waleh

18

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29 July 2017

Wan-Ru Chao

19

1 reference

Europe PubMed Central

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29 July 2017

Gen-Sheng Feng

20

1 reference

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29 July 2017

Yuhong Pang

21

1 reference

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29 July 2017

Ying Su

22

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29 July 2017

language of work or name

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publication date

30 August 2008

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29 July 2017

Journal of Medicinal Chemistry

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Europe PubMed Central

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29 July 2017

51

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29 July 2017

18

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Europe PubMed Central

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29 July 2017

5650-5662

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Structure and function of the atypical orphan nuclear receptor small heterodimer partner

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097887

5 July 2018

Synthesis and structure-activity relationships of new antiproliferative and proapoptotic retinoid-related biphenyl-4-yl-acrylic acids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097887

5 July 2018

SHP-2 tyrosine phosphatase inhibits p73-dependent apoptosis and expression of a subset of p53 target genes induced by EGCG.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097887

5 July 2018

Adamantyl-substituted retinoid-related molecules bind small heterodimer partner and modulate the Sin3A repressor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097887

5 July 2018

International Union of Pharmacology. LXVI. Orphan nuclear receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097887

5 July 2018

Dosage-sensitive sex reversal adrenal hypoplasia congenita critical region on the X chromosome, gene 1 (DAX1) (NR0B1) and small heterodimer partner (SHP) (NR0B2) form homodimers individually, as well as DAX1-SHP heterodimers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097887

5 July 2018

Global detection of molecular changes reveals concurrent alteration of several biological pathways in nonsmall cell lung cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097887

5 July 2018

Synthesis and structure-activity relationships of a new series of retinoid-related biphenyl-4-ylacrylic acids endowed with antiproliferative and proapoptotic activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097887

5 July 2018

Apoptosis induction by a novel retinoid-related molecule requires nuclear factor-kappaB activation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097887

5 July 2018

SHP represses transcriptional activity via recruitment of histone deacetylases.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097887

5 July 2018

Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097887

5 July 2018

Cellular and pharmacological bases of the antitumor activity of a novel adamantyl retinoid, ST1926.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097887

5 July 2018

Antagonist analogue of 6-[3'-(1-adamantyl)-4'-hydroxyphenyl]-2-naphthalenecarboxylic acid (AHPN) family of apoptosis inducers that effectively blocks AHPN-induced apoptosis but not cell-cycle arrest

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097887

5 July 2018

Apoptosis signaling by the novel compound 3-Cl-AHPC involves increased EGFR proteolysis and accompanying decreased phosphatidylinositol 3-kinase and AKT kinase activities.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097887

5 July 2018

Identification and characterization of a cell cycle and apoptosis regulatory protein-1 as a novel mediator of apoptosis signaling by retinoid CD437

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097887

5 July 2018

Gab1, SHP-2 and other novel regulators of Ras: targets for anticancer drug discovery?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097887

5 July 2018

Comparison of various types of hydrogen bonds involving aromatic amino acids.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097887

5 July 2018

Induction of apoptosis of human B-CLL and ALL cells by a novel retinoid and its nonretinoidal analog

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097887

5 July 2018

Molecular recognition of agonist ligands by RXRs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097887

5 July 2018

A transcriptional inhibitor targeted by the atypical orphan nuclear receptor SHP

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097887

5 July 2018

Retinoid-related molecules induce cytochrome c release and apoptosis through activation of c-Jun NH(2)-terminal kinase/p38 mitogen-activated protein kinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097887

5 July 2018

The structure of the ultraspiracle ligand-binding domain reveals a nuclear receptor locked in an inactive conformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097887

5 July 2018

Crystal structure of the ligand-binding domain of the ultraspiracle protein USP, the ortholog of retinoid X receptors in insects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097887

5 July 2018

Crystal structure of the human RXRalpha ligand-binding domain bound to its natural ligand: 9-cis retinoic acid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097887

5 July 2018

Identification of a unique binding protein specific for a novel retinoid inducing cellular apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097887

5 July 2018

An orphan nuclear hormone receptor that lacks a DNA binding domain and heterodimerizes with other receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097887

5 July 2018

Synthesis, structure-affinity relationships, and biological activities of ligands binding to retinoic acid receptor subtypes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097887

5 July 2018

p53 independent G0/G1 arrest and apoptosis induced by a novel retinoid in human breast cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097887

5 July 2018

An adamantyl-substituted retinoid-derived molecule that inhibits cancer cell growth and angiogenesis by inducing apoptosis and binds to small heterodimer partner nuclear receptor: effects of modifying its carboxylate group on apoptosis, proliferatio

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097887

29 October 2018

SHP-2 positively regulates adipogenic differentiation in 3T3-L1 cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097887

29 October 2018

The retinoid-X receptor ortholog, ultraspiracle, binds with nanomolar affinity to an endogenous morphogenetic ligand.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097887

29 October 2018

Unveiling hidden features of orphan nuclear receptors: the case of the small heterodimer partner (SHP).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097887

29 October 2018

Differential role of the loop region between helices H6 and H7 within the orphan nuclear receptors small heterodimer partner and DAX-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097887

29 October 2018

Induction of apoptosis in retinoid-refractory acute myelogenous leukemia by a novel AHPN analog.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097887

29 October 2018

A novel atypical retinoid endowed with proapoptotic and antitumor activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097887

29 October 2018

Differential response of human acute myeloid leukemia cells to gemtuzumab ozogamicin in vitro: role of Chk1 and Chk2 phosphorylation and caspase 3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097887

29 October 2018

Molecular effects of topoisomerase II inhibitors in AML cell lines: correlation of apoptosis with topoisomerase II activity but not with DNA damage.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097887

29 October 2018

Noonan syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097887

10 December 2018

A canonical structure for the ligand-binding domain of nuclear receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/18759424

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A selective retinoid with high activity against an androgen-resistant prostate cancer cell type

1 reference

https://pubmed.ncbi.nlm.nih.gov/18759424

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[Overexpression of Shp-2 is associated with the unlimited growth and apoptosis resistance of p210 bcr-abl-mediated chronic myeloid leukemia]

1 reference

https://pubmed.ncbi.nlm.nih.gov/18759424

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antitumor Activity of the Retinoid-Related Molecules (E)-3-(4'-Hydroxy-3'-adamantylbiphenyl-4-yl)acrylic Acid (ST1926) and 6-[3-(1-Adamantyl)-4-hydroxyphenyl]-2-naphthalene Carboxylic Acid (CD437) in F9 Teratocarcinoma: Role of Retinoic Acid Receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/18759424

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural and functional effects of disease-causing amino acid substitutions affecting residues Ala72 and Glu76 of the protein tyrosine phosphatase SHP-2

1 reference

https://pubmed.ncbi.nlm.nih.gov/18759424

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/JM800456K

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

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