(Q33904956)

29 July 2017

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title

Metabolic complications of obesity. Pathophysiologic considerations (English)

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29 July 2017

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Sheehan MT

1

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29 July 2017

Jensen MD

series ordinal

2

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29 July 2017

publication date

1 March 2000

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Medical Clinics of North America

29 July 2017

published in

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29 July 2017

volume

84

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29 July 2017

issue

2

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29 July 2017

page(s)

363-85, vi

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Relationships of generalized and regional adiposity to insulin sensitivity in men.

29 July 2017

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Comparison of body composition, adipocyte size, and glucose and insulin concentrations in Pima Indian and Caucasian children

7 January 2021

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Increased plasma cholesteryl ester transfer protein in obese subjects. A possible mechanism for the reduction of serum HDL cholesterol levels in obesity

7 January 2021

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Body composition, visceral fat, leptin, and insulin resistance in Asian Indian men.

7 January 2021

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Effects of free fatty acids and ketone bodies on in vivo non-insulin-mediated glucose utilization and production in humans

7 January 2021

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Caloric restriction reverses hepatic insulin resistance in aging rats by decreasing visceral fat.

7 January 2021

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Surgical removal of visceral fat reverses hepatic insulin resistance.

7 January 2021

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Regional differences in adrenoceptor binding and fat cell lipolysis in obese, postmenopausal women

7 January 2021

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Acute elevation of free fatty acid levels leads to hepatic insulin resistance in obese subjects.

7 January 2021

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Mechanisms of fatty acid-induced inhibition of glucose uptake

7 January 2021

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Effects of fat on insulin-stimulated carbohydrate metabolism in normal men

7 January 2021

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Chronic exposure to free fatty acid reduces pancreatic beta cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation

7 January 2021

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Basic and clinical aspects of regional fat distribution

7 January 2021

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The response to long-term overfeeding in identical twins

7 January 2021

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Visceral adiposity, fasting plasma insulin, and blood pressure in Japanese-Americans.

7 January 2021

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Body fat distribution and risk of non-insulin-dependent diabetes mellitus in women. The Nurses' Health Study

7 January 2021

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The effects of free fatty acids on gluconeogenesis and glycogenolysis in normal subjects

7 January 2021

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Mechanism of increased gluconeogenesis in noninsulin-dependent diabetes mellitus. Role of alterations in systemic, hepatic, and muscle lactate and alanine metabolism

7 January 2021

1 reference

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Increased hepatic secretion of very-low-density lipoprotein apolipoprotein B-100 in obesity: a stable isotope study

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0025-7125%2805%2970226-1

Increased hepatic secretion of very-low-density lipoprotein apolipoprotein B-100 in NIDDM

7 January 2021

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Oleic Acid Inhibits Endothelial Nitric Oxide Synthase by a Protein Kinase C–Independent Mechanism

7 January 2021

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Clinical implications of insulin resistance syndromes

7 January 2021

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Hyperleptinaemia: the missing link in the, metabolic syndrome?

7 January 2021

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The effect of insulin on renal sodium metabolism. A review with clinical implications

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0025-7125%2805%2970226-1

Evidence for a regional component of body fatness in the association with serum lipids in men and women

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0025-7125%2805%2970226-1

Hyperinsulinemia as an independent risk factor for ischemic heart disease.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0025-7125%2805%2970226-1

Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0025-7125%2805%2970226-1

Obesity hypertension is related more to insulin's fatty acid than glucose action.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0025-7125%2805%2970226-1

Relationship between skeletal muscle insulin resistance, insulin-mediated glucose disposal, and insulin binding. Effects of obesity and body fat topography

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0025-7125%2805%2970226-1

Effect of fatty acids on glucose production and utilization in man

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0025-7125%2805%2970226-1

Relation of body fatness and its distribution to cardiovascular risk factors in young blacks and whites. The role of insulin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0025-7125%2805%2970226-1

Diabetic dyslipidemia: basic mechanisms underlying the common hypertriglyceridemia and low HDL cholesterol levels

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0025-7125%2805%2970226-1

Relationships between plasma-free fatty acid concentration, endogenous glucose production, and fasting hyperglycemia in normal and non-insulin-dependent diabetic individuals.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0025-7125%2805%2970226-1

Nonesterified fatty acids in the pathogenesis of hypertension: theory and evidence

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0025-7125%2805%2970226-1

Pressor effects of portal venous oleate infusion. A proposed mechanism for obesity hypertension

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0025-7125%2805%2970226-1

Regional postprandial fatty acid metabolism in different obesity phenotypes.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0025-7125%2805%2970226-1

Blood glycerol is an important precursor for intramuscular triacylglycerol synthesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0025-7125%2805%2970226-1

Intralipid enhances alpha1-adrenergic receptor mediated pressor sensitivity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0025-7125%2805%2970226-1

Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0025-7125%2805%2970226-1

Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-alpha

7 January 2021

1 reference

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Tumor necrosis factor alpha inhibits signaling from the insulin receptor

7 January 2021

1 reference

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Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance

7 January 2021

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Response of insulin, glucagon, lactate, and nonesterified fatty acids to glucose in visceral obesity with and without NIDDM: relationship to hypertension.

7 January 2021

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Health consequences of fat distribution

7 January 2021

1 reference

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Influence of body fat distribution on free fatty acid metabolism in obesity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0025-7125%2805%2970226-1

Serum leptin concentration and insulin sensitivity in men with abdominal obesity.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0025-7125%2805%2970226-1

Underexpression of beta cell high Km glucose transporters in noninsulin-dependent diabetes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0025-7125%2805%2970226-1

Close correlation of intra-abdominal fat accumulation to hypertension in obese women

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0025-7125%2805%2970226-1

Relations of plasma TG and HDL-C concentrations to body composition and plasma insulin levels are altered in men with small LDL particles.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0025-7125%2805%2970226-1

Circulating TNF-alpha and leptin levels in offspring of NIDDM patients do not correlate to individual insulin sensitivity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0025-7125%2805%2970226-1

Interaction between glucose and free fatty acid metabolism in human skeletal muscle

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0025-7125%2805%2970226-1

The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0025-7125%2805%2970226-1

Role of insulin resistance in adipose tissue and liver in the pathogenesis of endogenous hypertriglyceridaemia in man

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0025-7125%2805%2970226-1

Regional adiposity and morbidity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0025-7125%2805%2970226-1

Relation of body fat distribution to metabolic complications of obesity.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0025-7125%2805%2970226-1

Obesity, non-insulin-dependent diabetes mellitus and the metabolic syndrome

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0025-7125%2805%2970226-1

Decreased effect of insulin to stimulate skeletal muscle blood flow in obese man. A novel mechanism for insulin resistance

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0025-7125%2805%2970226-1

Triglyceride enrichment of HDL enhances in vivo metabolic clearance of HDL apo A-I in healthy men.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0025-7125%2805%2970226-1

Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-beta-cell relationships

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0025-7125%2805%2970226-1

Interaction between free fatty acids and insulin in the acute control of very low density lipoprotein production in humans

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0025-7125%2805%2970226-1

Lipid infusion lowers sympathetic nervous activity and leads to increased beta-cell responsiveness to glucose

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0025-7125%2805%2970226-1

A prospective study of obesity and risk of coronary heart disease in women

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0025-7125%2805%2970226-1

Insulin sensitivity and serum triglyceride level in obese white and black women: relationship to visceral and truncal subcutaneous fat.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0025-7125%2805%2970226-1

Effects of body fat distribution on regional lipolysis in obesity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0025-7125%2805%2970226-1

Prolonged elevation of plasma free fatty acids desensitizes the insulin secretory response to glucose in vivo in rats

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0025-7125%2805%2970226-1

Is visceral adiposity a significant correlate of subcutaneous adipose cell lipolysis in men?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0025-7125%2805%2970226-1

Insulin resistance--mechanisms, syndromes, and implications

7 January 2021

1 reference

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Pioglitazone time-dependently reduces tumour necrosis factor-alpha level in muscle and improves metabolic abnormalities in Wistar fatty rats.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0025-7125%2805%2970226-1

Opposite effects of short- and long-term fatty acid infusion on insulin secretion in healthy subjects.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0025-7125%2805%2970226-1

Splanchnic insulin metabolism in obesity. Influence of body fat distribution

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0025-7125%2805%2970226-1

Glucose metabolism in obesity: influence of body fat distribution.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0025-7125%2805%2970226-1

TNF-alpha and insulin resistance: summary and future prospects

7 January 2021

1 reference

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Familial aggregation of abdominal visceral fat level: results from the Quebec family study.

7 January 2021

1 reference

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ApoB-100 gene EcoRI polymorphism. Relations to plasma lipoprotein changes associated with abdominal visceral obesity

7 January 2021

1 reference

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Central adiposity and increased risk of coronary artery disease mortality in older women

7 January 2021

1 reference

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Lipolysis and gluconeogenesis from glycerol are increased in patients with noninsulin-dependent diabetes mellitus

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0025-7125%2805%2970226-1

The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus

7 January 2021

1 reference

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Hypertension and associated metabolic abnormalities--the role of insulin resistance and the sympathoadrenal system

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0025-7125%2805%2970226-1

Familial resemblance for abdominal visceral fat: the HERITAGE family study

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0025-7125%2805%2970226-1

Hepatic secretion of very-low-density lipoprotein apolipoprotein B-100 studied with a stable isotope technique in men with visceral obesity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0025-7125%2805%2970226-1

Body size and fat distribution as predictors of coronary heart disease among middle-aged and older US men.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0025-7125%2805%2970226-1

Visceral adiposity, androgens, and plasma lipids in obese men

7 January 2021

1 reference

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Mechanism of free fatty acid-induced insulin resistance in humans

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0025-7125%2805%2970226-1

Decreased muscle glucose transport/phosphorylation is an early defect in the pathogenesis of non-insulin-dependent diabetes mellitus

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0025-7125%2805%2970226-1

31P nuclear magnetic resonance measurements of muscle glucose-6-phosphate. Evidence for reduced insulin-dependent muscle glucose transport or phosphorylation activity in non-insulin-dependent diabetes mellitus

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0025-7125%2805%2970226-1

A 48-hour lipid infusion in the rat time-dependently inhibits glucose-induced insulin secretion and B cell oxidation through a process likely coupled to fatty acid oxidation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0025-7125%2805%2970226-1

Modulation of hepatic glucose production by non-esterified fatty acids in type 2 (non-insulin-dependent) diabetes mellitus

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0025-7125%2805%2970226-1

Nitric oxide release accounts for insulin's vascular effects in humans

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0025-7125%2805%2970226-1

Relationship between angiotensinogen, leptin and blood pressure levels in young normotensive men

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0025-7125%2805%2970226-1

Visceral fat accumulation in men is positively associated with insulin, glucose, and C-peptide levels, but negatively with testosterone levels

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0025-7125%2805%2970226-1

Body fat distribution in relation to serum lipids and blood pressure in 38-year-old European men: the European fat distribution study

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0025-7125%2805%2970226-1

Intracerebroventricular administration of leptin markedly enhances insulin sensitivity and systemic glucose utilization in conscious rats.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0025-7125%2805%2970226-1

Effects of insulin on kidney function and sodium excretion in healthy subjects

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0025-7125%2805%2970226-1

Effect of insulin on renal sodium handling in hyperinsulinaemic type 2 (non-insulin-dependent) diabetic patients with peripheral insulin resistance.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0025-7125%2805%2970226-1

Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0025-7125%2805%2970226-1

Elevated circulating free fatty acid levels impair endothelium-dependent vasodilation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0025-7125%2805%2970226-1

The dense LDL phenotype. Association with plasma lipoprotein levels, visceral obesity, and hyperinsulinemia in men.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0025-7125%2805%2970226-1

Effect of long chain triglyceride infusion on glucose metabolism in man

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0025-7125%2805%2970226-1

The degree of masculine differentiation of obesities: a factor determining predisposition to diabetes, atherosclerosis, gout, and uric calculous disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0025-7125%2805%2970226-1

The lipoprotein lipase HindIII polymorphism modulates plasma triglyceride levels in visceral obesity.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0025-7125%2805%2970226-1

Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0025-7125%2805%2970226-1

Central adipose distribution is related to coronary atherosclerosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0025-7125%2805%2970226-1

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1016/S0025-7125(05)70226-1

1 reference

29 July 2017

1 reference