(Q33911979)

30 July 2017

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title

Epothilones and related structures--a new class of microtubule inhibitors with potent in vivo antitumor activity (English)

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30 July 2017

K H Altmann

1

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30 July 2017

M Wartmann

series ordinal

2

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30 July 2017

T O'Reilly

series ordinal

3

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30 July 2017

language of work or name

English

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publication date

1 May 2000

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Biochimica et Biophysica Acta

30 July 2017

published in

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30 July 2017

volume

1470

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30 July 2017

issue

3

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30 July 2017

page(s)

M79-91

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THE DEVELOPMENT AND CLINICAL UTILITY OF THE TAXANE CLASS OF ANTIMICROTUBULE CHEMOTHERAPY AGENTS

30 July 2017

cites work

1 reference

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7 January 2021

Taxol stabilizes microtubules in mouse fibroblast cells

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7 January 2021

Epothilons A and B: antifungal and cytotoxic compounds from Sorangium cellulosum (Myxobacteria). Production, physico-chemical and biological properties

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7 January 2021

Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than taxol

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7 January 2021

The coral-derived natural products eleutherobin and sarcodictyins A and B: effects on the assembly of purified tubulin with and without microtubule-associated proteins and binding at the polymer taxoid site.

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7 January 2021

Epothilone A and B—Novel 16-Membered Macrolides with Cytotoxic Activity: Isolation, Crystal Structure, and Conformation in Solution

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7 January 2021

Improved synthesis of epothilone B employing alkylation of an alkyne for assembly of subunits

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7 January 2021

A Highly Stereoselective Synthesis of Epothilone B

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7 January 2021

Activities of the microtubule-stabilizing agents epothilones A and B with purified tubulin and in cells resistant to paclitaxel (Taxol(R)).

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7 January 2021

Microtubule dynamics: taking aim at a moving target

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7 January 2021

Desoxyepothilone B: an efficacious microtubule-targeted antitumor agent with a promising in vivo profile relative to epothilone B.

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7 January 2021

A derivative of staurosporine (CGP 41 251) shows selectivity for protein kinase C inhibition and in vitro anti-proliferative as well as in vivo anti-tumor activity

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7 January 2021

The microtubule-stabilizing agents epothilones A and B and their desoxy-derivatives induce mitotic arrest and apoptosis in human prostate cancer cells.

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7 January 2021

Farnesyl transferase inhibitors cause enhanced mitotic sensitivity to taxol and epothilones

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7 January 2021

Paclitaxel-resistant human ovarian cancer cells have mutant beta-tubulins that exhibit impaired paclitaxel-driven polymerization

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7 January 2021

Synthesis and biological properties of C12,13-cyclopropyl-epothilone A and related epothilones

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7 January 2021

Designed Epothilones: Combinatorial Synthesis, Tubulin Assembly Properties, abd Cytotoxic Action against Taxol-Resistant Tumor Cells

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7 January 2021

Total Synthesis of(–)-Epothilone B: An Extension of the Suzuki Coupling Method and Insights into Structure–Activity Relationships of the Epothilones

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7 January 2021

Derivatization of the C12-C13 functional groups of epothilones A, B and C

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7 January 2021

Oxidative and reductive transformations of epothilone A

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7 January 2021

Chemical Biology of Epothilones

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7 January 2021

Desoxyepothilone B is curative against human tumor xenografts that are refractory to paclitaxel.

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7 January 2021

Structure of the alpha beta tubulin dimer by electron crystallography

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7 January 2021

A common pharmacophore for cytotoxic natural products that stabilize microtubules

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7 January 2021

A unified and quantitative receptor model for the microtubule binding of paclitaxel and epothilone

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2800%2900009-3

7 January 2021

10.1016/S0304-419X(00)00009-3

Identifiers

DOI

1 reference

30 July 2017

1 reference