(Q33920473)

30 July 2017

title

Diacylglycerol kinase ζ limits the generation of natural regulatory T cells (English)

1 reference

30 July 2017

Amanda M Schmidt

1

1 reference

30 July 2017

Tao Zou

2

1 reference

30 July 2017

Rohan P Joshi

3

1 reference

30 July 2017

Theresa M Leichner

4

1 reference

30 July 2017

Matthew A Pimentel

5

1 reference

30 July 2017

Connie L Sommers

6

1 reference

30 July 2017

Taku Kambayashi

7

1 reference

30 July 2017

publication date

26 November 2013

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30 July 2017

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30 July 2017

volume

6

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30 July 2017

issue

303

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30 July 2017

page(s)

ra101

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The ζ isoform of diacylglycerol kinase plays a predominant role in regulatory T cell development and TCR-mediated ras signaling

30 July 2017

cites work

1 reference

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Thymus-derived regulatory T cells contribute to tolerance to commensal microbiota

5 July 2018

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A broad range of self-reactivity drives thymic regulatory T cell selection to limit responses to self.

5 July 2018

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5 July 2018

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Foxp3(+) regulatory T cells, immune stimulation and host defence against infection

5 July 2018

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5 July 2018

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c-Rel controls multiple discrete steps in the thymic development of Foxp3+ CD4 regulatory T cells

5 July 2018

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Regulation of NF-κB induction by TCR/CD28.

5 July 2018

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T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse

5 July 2018

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Negative regulation of mTOR activation by diacylglycerol kinases

5 July 2018

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Becoming self-aware: the thymic education of regulatory T cells.

5 July 2018

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NF-κB family of transcription factors: biochemical players of CD28 co-stimulation.

5 July 2018

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Interleukin-2 Receptor Signaling: At the Interface between Tolerance and Immunity

5 July 2018

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Independent and cooperative roles of adaptor molecules in proximal signaling during FcepsilonRI-mediated mast cell activation

5 July 2018

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Cutting edge: CD28 and c-Rel-dependent pathways initiate regulatory T cell development.

5 July 2018

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Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103616

Development of Foxp3(+) regulatory t cells is driven by the c-Rel enhanceosome

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103616

c-Rel is required for the development of thymic Foxp3+ CD4 regulatory T cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103616

Runx-CBFbeta complexes control expression of the transcription factor Foxp3 in regulatory T cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103616

Regulatory T cell differentiation of thymocytes does not require a dedicated antigen-presenting cell but is under T cell-intrinsic developmental control.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103616

5 July 2018

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Spatiotemporal regulation of T cell costimulation by TCR-CD28 microclusters and protein kinase C theta translocation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103616

Diacylglycerol kinases in immune cell function and self-tolerance

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103616

Regulatory T cells and immune tolerance

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103616

T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103616

The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103616

Linked T cell receptor and cytokine signaling govern the development of the regulatory T cell repertoire.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103616

A two-step process for thymic regulatory T cell development.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103616

Interleukin-2 receptor signaling in regulatory T cell development and homeostasis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103616

Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103616

Regulatory T cells and cancer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103616

Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103616

Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103616

Both integrated and differential regulation of components of the IL-2/IL-2 receptor system

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103616

Molecular mechanisms underlying FOXP3 induction in human T cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103616

Sequential development of interleukin 2-dependent effector and regulatory T cells in response to endogenous systemic antigen

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103616

Developmental regulation of Foxp3 expression during ontogeny.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103616

Natural regulatory T cells in infectious disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103616

CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103616

Enhanced T cell responses due to diacylglycerol kinase zeta deficiency

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103616

Antigen-dependent proliferation of CD4+ CD25+ regulatory T cells in vivo

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103616

Move over protein kinase C, you've got company: alternative cellular effectors of diacylglycerol and phorbol esters.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103616

Regulation of T cell receptor-induced activation of the Ras-ERK pathway by diacylglycerol kinase zeta

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103616

The basis for TCR-mediated regulation of the IL-2 receptor alpha chain gene: role of widely separated regulatory elements

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103616

Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103616

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103616

Signal transduction by the TCR for antigen

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103616

Identification of a novel inhibitor of mitogen-activated protein kinase kinase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103616

The influence of the MAPK pathway on T cell lineage commitment

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103616

p95vav associates with tyrosine-phosphorylated SLP-76 in antigen-stimulated T cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103616

Negative selection in the thymus includes semimature T cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103616

The extracellular signal-regulated kinase pathway phosphorylates AML1, an acute myeloid leukemia gene product, and potentially regulates its transactivation ability

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103616

Regulation of cell-type-specific interleukin-2 receptor alpha-chain gene expression: potential role of physical interactions between Elf-1, HMG-I(Y), and NF-kappa B family proteins

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103616

Identification of genes induced during apoptosis in T lymphocytes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103616

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103616

Kappa B site-dependent activation of the interleukin-2 receptor alpha-chain gene promoter by human c-Rel

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103616

Disruption of diacylglycerol metabolism impairs the induction of T cell anergy.

5 July 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004411

Nuclear factor-kappaB modulates regulatory T cell development by directly regulating expression of Foxp3 transcription factor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004411

Multiple phosphorylation sites are important for RUNX1 activity in early hematopoiesis and T-cell differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004411

Membrane translocation of protein kinase Ctheta during T lymphocyte activation requires phospholipase C-gamma-generated diacylglycerol

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004411

c-Rel is crucial for lymphocyte proliferation but dispensable for T cell effector function

21 January 2018

1 reference

12 December 2020

Transcriptional analysis of clonal deletion in vivo

1 reference

12 December 2020

c-Rel but not NF-κB1 is important for T regulatory cell development

1 reference

12 December 2020

Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

1 reference

12 December 2020

Control of intestinal inflammation by regulatory T cells

1 reference

12 December 2020

Generation of CD4(+)CD25(+) regulatory T cells from autoreactive T cells simultaneously with their negative selection in the thymus and from nonautoreactive T cells by endogenous TCR expression

1 reference

12 December 2020

Origin of regulatory T cells with known specificity for antigen

1 reference

12 December 2020

10.1126/SCISIGNAL.2004411

Identifiers

DOI

1 reference

30 July 2017

1 reference

30 July 2017

1 reference