(Q33925505)

30 July 2017

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title

5-Fluorouracil: forty-plus and still ticking. A review of its preclinical and clinical development (English)

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30 July 2017

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Grem JL

1

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PubMed ID

11081567

30 July 2017

language of work or name

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1 November 2000

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Investigational New Drugs

30 July 2017

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30 July 2017

18

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30 July 2017

299-313

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30 July 2017

4

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https://scigraph.springernature.com/pub.10.1023/a:1006416410198

30 July 2017

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cites work

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12 December 2020

Ratio of 2'-deoxyadenosine-5'-triphosphate/thymidine-5'-triphosphate influences the commitment of human colon carcinoma cells to thymineless death.

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12 December 2020

Phase I trial of 5-fluorouracil and dipyridamole administered by seventy-two-hour concurrent continuous infusion

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12 December 2020

Regulation of thymidylate synthase enzyme synthesis in 5-fluorodeoxyuridine-resistant mouse fibroblasts during the transition from the resting to growing state

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12 December 2020

Novel mechanism(s) of resistance to 5-fluorouracil in human colon cancer (HCT-8) sublines following exposure to two different clinically relevant dose schedules

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12 December 2020

Efficacy of intravenous continuous infusion of fluorouracil compared with bolus administration in advanced colorectal cancer

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12 December 2020

Etoposide-induced cytotoxicity in two human T-cell leukemic lines: delayed loss of membrane permeability rather than DNA fragmentation as an indicator of programmed cell death.

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12 December 2020

Pharmacokinetic and pharmacodynamic analysis of fluorouracil during 72-hour continuous infusion with and without dipyridamole

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12 December 2020

Fluorouracil therapy in patients with carcinoma of the large bowel: a pharmacokinetic comparison of various rates and routes of administration

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12 December 2020

Effect of interferon on 5-fluorouracil-induced perturbations in pools of deoxynucleotide triphosphates and DNA strand breaks

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12 December 2020

Age and sex are independent predictors of 5-fluorouracil toxicity. Analysis of a large scale phase III trial

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12 December 2020

Preclinical and phase I clinical studies with the nonclassical antifolate thymidylate synthase inhibitor nolatrexed dihydrochloride given by prolonged administration in patients with solid tumors

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12 December 2020

A double-blind comparison of intensive course 5-fluorouracil by oral vs. intravenous route in the treatment of colorectal carcinoma

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12 December 2020

Epidermoid anal cancer: results from the UKCCCR randomised trial of radiotherapy alone versus radiotherapy, 5-fluorouracil, and mitomycin. UKCCCR Anal Cancer Trial Working Party. UK Co-ordinating Committee on Cancer Research

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12 December 2020

Population characteristics of hepatic dihydropyrimidine dehydrogenase activity, a key metabolic enzyme in 5-fluorouracil chemotherapy

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12 December 2020

A phase II study of continuous infusion 5-fluorouracil and leucovorin with weekly cisplatin in metastatic colorectal carcinoma

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12 December 2020

Pharmacokinetics of 5-fluorouracil assessed with a sensitive mass spectrometric method in patients on a dose escalation schedule

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12 December 2020

Nonlinear pharmacokinetics for the elimination of 5-fluorouracil after intravenous administration in cancer patients

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12 December 2020

Thymidylate synthase protein expression: Association with response to neoadjuvant chemotherapy and resection for locally advanced gastric and gastroesophageal adenocarcinoma

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12 December 2020

Mechanism of interaction of thymidylate synthetase with 5-fluorodeoxyuridylate.

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12 December 2020

Randomised multicentre trial of chronotherapy with oxaliplatin, fluorouracil, and folinic acid in metastatic colorectal cancer. International Organization for Cancer Chronotherapy

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12 December 2020

Adjuvant postoperative fluorouracil-modulated chemotherapy combined with pelvic radiation therapy for rectal cancer: initial results of intergroup 0114

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12 December 2020

Haematological and non-haematological toxicity after 5-fluorouracil and leucovorin in patients with advanced colorectal cancer is significantly associated with gender, increasing age and cycle number. Tomudex International Study Group.

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12 December 2020

Resistance to fluorodeoxyuridine-induced DNA damage and cytotoxicity correlates with an elevation of deoxyuridine triphosphatase activity and failure to accumulate deoxyuridine triphosphate.

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12 December 2020

A specialized form of chromosomal DNA degradation induced by thymidylate stress in mouse FM3A cells

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12 December 2020

Quantitation of intratumoral thymidylate synthase expression predicts for disseminated colorectal cancer response and resistance to protracted-infusion fluorouracil and weekly leucovorin

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12 December 2020

Role of thymidine phosphorylase activity in the angiogenic effect of platelet derived endothelial cell growth factor/thymidine phosphorylase.

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12 December 2020

Thymidylate synthase mRNA level in adenocarcinoma of the stomach: a predictor for primary tumor response and overall survival

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12 December 2020

The inhibitory effects of 5-fluorouracil on the metabolism of preribosomal and ribosomal RNA in L-1210 cells in vitro

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12 December 2020

Phase I trial of the thymidylate synthase inhibitor AG331 as a 5-day continuous infusion

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12 December 2020

Thymineless death in colon carcinoma cells is mediated via fas signaling

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12 December 2020

Acute effect of 5-fluorouracil on cytoplasmic and nuclear dihydrofolate reductase messenger RNA metabolism

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12 December 2020

Phase I and pharmacokinetic study of recombinant human granulocyte-macrophage colony-stimulating factor given in combination with fluorouracil plus calcium leucovorin in metastatic gastrointestinal adenocarcinoma

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12 December 2020

New mechanism of action of the cancer chemotherapeutic agent 5-fluorouracil in human cells

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12 December 2020

Overview of current status and future direction of clinical trials with 5-fluorouracil in combination with folinic acid

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12 December 2020

Pharmacokinetic studies of 5-fluorouracil after oral and intravenous administration in man

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12 December 2020

Randomized trial comparing monthly low-dose leucovorin and fluorouracil bolus with bimonthly high-dose leucovorin and fluorouracil bolus plus continuous infusion for advanced colorectal cancer: a French intergroup study

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12 December 2020

Influence of sex and age on fluorouracil clearance

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12 December 2020

Concomitant radiotherapy and chemotherapy is superior to radiotherapy alone in the treatment of locally advanced anal cancer: results of a phase III randomized trial of the European Organization for Research and Treatment of Cancer Radiotherapy and

1 reference

12 December 2020

Mechanisms of excision of 5-fluorouracil by uracil DNA glycosylase in normal human cells.

1 reference

12 December 2020

Down-regulation of c-myc gene expression with induction of high molecular weight DNA fragments by fluorodeoxyuridine.

1 reference

12 December 2020

Activity of high dose 24 hour 5-fluorouracil infusion plus L-leucovorin in advanced colorectal cancer

1 reference

12 December 2020

Effect of polyglutamylation of 5,10-methylenetetrahydrofolate on the binding of 5-fluoro-2'-deoxyuridylate to thymidylate synthase purified from a human colon adenocarcinoma xenograft

1 reference

12 December 2020

5-FU therapeutic monitoring with dose adjustment leads to an improved therapeutic index in head and neck cancer

1 reference

12 December 2020

5-Fluorouracil alters dihydrofolate reductase pre-mRNA splicing as determined by quantitative polymerase chain reaction

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12 December 2020

Plasma pharmacokinetics of 5-FU given by continuous infusion with allopurinol

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12 December 2020

Assessment of growth-limiting events caused by 5-fluorouracil in mouse cells and in human cells

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12 December 2020

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

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12 December 2020

Specific inhibition of pre-ribosomal RNA processing in extracts from the lymphosarcoma cells treated with 5-fluorouracil

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12 December 2020

Ribonucleoprotein particle assembly and modification of U2 small nuclear RNA containing 5-fluorouridine

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12 December 2020

Autoregulation of human thymidylate synthase messenger RNA translation by thymidylate synthase

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12 December 2020

Nonlinear pharmacokinetic models for 5-fluorouracil in man: intravenous and intraperitoneal routes

1 reference

12 December 2020

Clinical pharmacokinetic study of 5-FU in continuous 5-day infusions for head and neck cancer

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12 December 2020

A clinical-pharmacological evaluation of hepatic arterial infusions of 5-fluoro-2'-deoxyuridine and 5-fluorouracil

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12 December 2020

Determinants of cytotoxicity with prolonged exposure to fluorouracil in human colon cancer cells.

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12 December 2020

Pharmacokinetics of 5-fluorouracil administered orally, by rapid intravenous and by slow infusion

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12 December 2020

Circadian rhythm-varying plasma concentration of 5-fluorouracil during a five-day continuous venous infusion at a constant rate in cancer patients

1 reference

12 December 2020

Chemoradiotherapy of locally advanced esophageal cancer: long-term follow-up of a prospective randomized trial (RTOG 85-01). Radiation Therapy Oncology Group

1 reference

12 December 2020

Variations in patterns of DNA damage induced in human colorectal tumor cells by 5-fluorodeoxyuridine: implications for mechanisms of resistance and cytotoxicity

1 reference

12 December 2020

1 reference

12 December 2020

Inhibition by 5-fluorouracil of ERCC1 and gamma-glutamylcysteine synthetase messenger RNA expression in a cisplatin-resistant HST-1 human squamous carcinoma cell line

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12 December 2020

Clinical significance of monitoring serum levels of 5-fluorouracil by continuous infusion in patients with advanced colonic cancer

1 reference

12 December 2020

Cytotoxicity of 5-fluoro-2'-deoxyuridine: requirement for reduced folate cofactors and antagonism by methotrexate

1 reference

12 December 2020

An alternative molecular mechanism of action of 5-fluorouracil, a potent anticancer drug

1 reference

12 December 2020

Pelvic radiation with concurrent chemotherapy compared with pelvic and para-aortic radiation for high-risk cervical cancer

1 reference

12 December 2020

Interaction of deoxyuridine with fluorouracil and dipyridamole in a human colon cancer cell line

1 reference

12 December 2020

5-Fluorouracil inhibits dihydrofolate reductase precursor mRNA processing and/or nuclear mRNA stability in methotrexate-resistant KB cells

1 reference

12 December 2020

Catalytic mechanism and inhibition of tRNA (uracil-5-)methyltransferase: evidence for covalent catalysis

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12 December 2020

Association of cell lethality with incorporation of 5-fluorouracil and 5-fluorouridine into nuclear RNA in human colon carcinoma cells in culture

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12 December 2020

5-Fluorouracil suppresses nitric oxide biosynthesis in colon carcinoma cells

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12 December 2020

Combined chemotherapy and radiotherapy compared with radiotherapy alone in patients with cancer of the esophagus

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12 December 2020

Clinical pharmacokinetics of 5-fluorouracil and its metabolites in plasma, urine, and bile

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12 December 2020

Clinical pharmacology of oral and intravenous 5-fluorouracil (NSC-19893).

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12 December 2020

Kinetics and thermodynamics of the interaction of 5-fluoro-2'-deoxyuridylate with thymidylate synthase

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12 December 2020

Levels of thymidylate synthetase during normal culture growth of L1210 cells

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12 December 2020

Effect of 5-fluorouracil substitution on the self-splicing activity of Tetrahymena ribosomal RNA.

1 reference

12 December 2020

Clinical impact of pharmacokinetically-guided dose adaptation of 5-fluorouracil: results from a multicentric randomized trial in patients with locally advanced head and neck carcinomas

1 reference

12 December 2020

Mechanism of cell death following thymidylate synthase inhibition: 2'-deoxyuridine-5'-triphosphate accumulation, DNA damage, and growth inhibition following exposure to CB3717 and dipyridamole

1 reference

12 December 2020

Plasma levels of 5-fluorouracil after oral and intravenous administration in cancer patients

1 reference

12 December 2020

Effects of 5-fluorouracil substitution on the RNA conformation and in vitro translation of thymidylate synthase messenger RNA

1 reference

12 December 2020

Modulation of fluorouracil cytotoxicity by interferon-alpha and -gamma

1 reference

12 December 2020

A Fas-dependent component in 5-fluorouracil/leucovorin-induced cytotoxicity in colon carcinoma cells

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12 December 2020

Pharmacokinetics of fluorouracil in humans

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12 December 2020

5-Fluorouracil substitution alters pre-mRNA splicing in vitro

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12 December 2020

Toxicity of fluorouracil in patients with advanced colorectal cancer: effect of administration schedule and prognostic factors.

1 reference

12 December 2020

The pharmacokinetics of 5-fluorouracil administered by arterial infusion in advanced colorectal hepatic metastases

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12 December 2020

Effect of 5-fluoro- and 5-bromouracil substitution on the translation of human thymidylate synthase mRNA.

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12 December 2020

The effects of 5-fluoropyrimidines on nascent DNA synthesis in Chinese hamster ovary cells monitored by pH-step alkaline and neutral elution

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12 December 2020

Dihydropyrimidine dehydrogenase activity in human peripheral blood mononuclear cells and liver: population characteristics, newly identified deficient patients, and clinical implication in 5-fluorouracil chemotherapy

1 reference

12 December 2020

Relationship between dihydropyrimidine dehydrogenase activity and plasma 5-fluorouracil levels with evidence for circadian variation of enzyme activity and plasma drug levels in cancer patients receiving 5-fluorouracil by protracted continuous infus

1 reference

12 December 2020

Enhanced cytotoxicity with interleukin-1 alpha and 5-fluorouracil in HCT116 colon cancer cells

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12 December 2020

Elevation of thymidylate synthase following 5-fluorouracil treatment is prevented by the addition of leucovorin in murine colon tumors

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12 December 2020

bcl-2 modulation of apoptosis induced by anticancer drugs: resistance to thymidylate stress is independent of classical resistance pathways.

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12 December 2020

Regulation of thymidylate synthase in human colon cancer cells treated with 5-fluorouracil and interferon-gamma.

1 reference

12 December 2020

Purification and amino acid analysis of an active site peptide from thymidylate synthetase containing covalently bound 5-fluoro-2'-deoxyuridylate and methylenetetrahydrofolate.

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12 December 2020

A pilot study of interferon alfa-2a in combination with fluorouracil plus high-dose leucovorin in metastatic gastrointestinal carcinoma

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12 December 2020

Steady-state nonlinear pharmacokinetics of 5-fluorouracil during hepatic arterial and intravenous infusions in cancer patients.

1 reference

12 December 2020

Deoxyribonucleoside triphosphate imbalance. 5-Fluorodeoxyuridine-induced DNA double strand breaks in mouse FM3A cells and the mechanism of cell death

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12 December 2020

Fluorouracil and high-dose leucovorin in previously treated patients with metastatic breast cancer.

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12 December 2020

Synergism and lack of cross-resistance between short-term and continuous exposure to fluorouracil in human colon adenocarcinoma cells

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12 December 2020

Inhibition by uridine but not thymidine of p53-dependent intestinal apoptosis initiated by 5-fluorouracil: evidence for the involvement of RNA perturbation

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12 December 2020

Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors

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12 December 2020

Cytotoxicity and DNA fragmentation associated with sequential gemcitabine and 5-fluoro-2'-deoxyuridine in HT-29 colon cancer cells.

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12 December 2020

Immunoreactive dUMP and TTP pools as an index of thymidylate synthase inhibition; effect of tomudex (ZD1694) and a nonpolyglutamated quinazoline antifolate (CB30900) in L1210 mouse leukaemia cells

1 reference

12 December 2020

Meta-analysis of randomized trials testing the biochemical modulation of fluorouracil by methotrexate in metastatic colorectal cancer. Advanced Colorectal Cancer Meta-Analysis Project

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12 December 2020

Fluorinated pyrimidines, a new class of tumour-inhibitory compounds

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12 December 2020

Improving adjuvant therapy for rectal cancer by combining protracted-infusion fluorouracil with radiation therapy after curative surgery

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12 December 2020

Studies in 2-acetylaminofluorene carcinogenesis. III. The utilization of uracil-2-C14 by preneoplastic rat liver and rat hepatoma.

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12 December 2020

Interaction of gamma interferon and 5-fluorouracil in the H630 human colon carcinoma cell line

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12 December 2020

A phase I study of continuous infusion 5-fluorouracil plus calcium leucovorin in combination with N-(phosphonacetyl)-L-aspartate in metastatic gastrointestinal adenocarcinoma

1 reference

12 December 2020

Incorporation of 5-fluorouracil into U2 and U6 snRNA inhibits mRNA precursor splicing.

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12 December 2020

Regulation of thymidylate synthetase in mouse leukemia cells (L1210)

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12 December 2020

Fluorouracil in colorectal cancer--a tale of two drugs: implications for biochemical modulation

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12 December 2020

Significance of variation in serum thymidine concentration for the marrow toxicity of methotrexate

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12 December 2020

Structure/function analysis of a dUTPase: catalytic mechanism of a potential chemotherapeutic target

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12 December 2020

Chronomodulated versus fixed-infusion-rate delivery of ambulatory chemotherapy with oxaliplatin, fluorouracil, and folinic acid (leucovorin) in patients with colorectal cancer metastases: a randomized multi-institutional trial

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12 December 2020

Altered plasma kinetics of 5-FU at high dosage in rat and man

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12 December 2020

Correlation between dihydropyrimidine dehydrogenase activity in peripheral mononuclear cells and systemic clearance of fluorouracil in cancer patients

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12 December 2020

Inter- and intraindividual variation in dihydropyrimidine dehydrogenase activity in peripheral blood mononuclear cells

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12 December 2020

Dihydropyrimidine dehydrogenase activity in cancer patients

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12 December 2020

Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: evidence in terms of response rate. Advanced Colorectal Cancer Meta-Analysis Project

1 reference

12 December 2020

High inter- and intrapatient variation in 5-fluorouracil plasma concentrations during a prolonged drug infusion.

1 reference

12 December 2020

Dihydropyrimidine dehydrogenase activity in human blood mononuclear cells

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12 December 2020

Identifiers

DOI

10.1023/A:1006416410198

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PubMed ID

11081567

Dimensions Publication ID

30 July 2017

0 references

1 reference

PubMed ID

11081567