(Q33927058)

English

Efficient targeting of head and neck squamous cell carcinoma by systemic administration of a dual uPA and MMP-activated engineered anthrax toxin

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Efficient targeting of head and neck squamous cell carcinoma by systemic administration of a dual uPA and MMP-activated engineered anthrax toxin (English)

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

0 references

head and neck squamous cell carcinoma

1 reference

based on heuristic

inferred from title

Stephen H. Leppla

6

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Thomas H. Bugge

7

object named as

Thomas H Bugge

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

4

object named as

Shihui Liu

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Alfredo A Molinolo

5

object named as

Alfredo A Molinolo

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

author name string

Jeffrey M Schafer

1

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Diane E Peters

2

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Thomas Morley

3

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

language of work or name

0 references

publication date

31 May 2011

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

6

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

5

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

e20532

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

copyright license

Creative Commons CC0 License

31 May 2011

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted, dedicated to the public domain by copyright holder

0 references

c-Met-induced epithelial carcinogenesis is initiated by the serine protease matriptase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3105081

5 July 2018

Anthrax toxin targeting of myeloid cells through the CMG2 receptor is essential for establishment of Bacillus anthracis infections in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3105081

5 July 2018

Selective abrogation of the uPA-uPAR interaction in vivo reveals a novel role in suppression of fibrin-associated inflammation

1 reference

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5 July 2018

Inhibition of tumor angiogenesis by the matrix metalloproteinase-activated anthrax lethal toxin in an orthotopic model of anaplastic thyroid carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3105081

5 July 2018

In vivo characterization of activatable cell penetrating peptides for targeting protease activity in cancer

1 reference

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5 July 2018

Capillary morphogenesis protein-2 is the major receptor mediating lethality of anthrax toxin in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3105081

5 July 2018

Matrix metalloproteinase-activated anthrax lethal toxin inhibits endothelial invasion and neovasculature formation during in vitro morphogenesis

1 reference

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5 July 2018

Multiple kallikrein (KLK 5, 7, 8, and 10) expression in squamous cell carcinoma of the oral cavity

1 reference

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5 July 2018

Dysregulated molecular networks in head and neck carcinogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3105081

5 July 2018

Role of N-terminal amino acids in the potency of anthrax lethal factor

1 reference

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5 July 2018

Utility of kallikrein-related peptidases (KLKs) as cancer biomarkers

1 reference

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5 July 2018

Cytotoxicity of the matrix metalloproteinase-activated anthrax lethal toxin is dependent on gelatinase expression and B-RAF status in human melanoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3105081

5 July 2018

Cancer statistics, 2008

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3105081

5 July 2018

Potent inhibition of tumor angiogenesis by the matrix metalloproteinase-activated anthrax lethal toxin: implications for broad anti-tumor efficacy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3105081

5 July 2018

Matrix metalloproteinase-activated anthrax lethal toxin demonstrates high potency in targeting tumor vasculature

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3105081

5 July 2018

Urinary-type plasminogen activator (uPA) and its receptor (uPAR) in squamous cell carcinoma of the oral cavity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3105081

5 July 2018

Characterization of the interaction between anthrax toxin and its cellular receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3105081

5 July 2018

A prostate-specific antigen-activated channel-forming toxin as therapy for prostatic disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3105081

5 July 2018

A urokinase-activated recombinant anthrax toxin is selectively cytotoxic to many human tumor cell types

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3105081

5 July 2018

Cysteine cathepsins: multifunctional enzymes in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3105081

5 July 2018

Matrix metalloproteases in head and neck cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3105081

5 July 2018

Toxin conjugate therapy of cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3105081

5 July 2018

Intermolecular complementation achieves high-specificity tumor targeting by anthrax toxin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3105081

5 July 2018

Global cancer statistics, 2002

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3105081

5 July 2018

Detection of plasminogen activators in oral cancer by laser capture microdissection combined with zymography

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3105081

5 July 2018

Focus on head and neck cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3105081

5 July 2018

Culture characteristics of four permanent lines of human cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3105081

5 July 2018

Studies on the propagation in vitro of poliomyelitis viruses. IV. Viral multiplication in a stable strain of human malignant epithelial cells (strain HeLa) derived from an epidermoid carcinoma of the cervix

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3105081

5 July 2018

Anthrax toxin: structures, functions and tumour targeting

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3105081

5 July 2018

Human capillary morphogenesis protein 2 functions as an anthrax toxin receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3105081

5 July 2018

Potent antitumor activity of a urokinase-activated engineered anthrax toxin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3105081

5 July 2018

Cell surface tumor endothelium marker 8 cytoplasmic tail-independent anthrax toxin binding, proteolytic processing, oligomer formation, and internalization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3105081

5 July 2018

Peptide toxins directed at the matrix dissolution systems of cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3105081

5 July 2018

The lethal and edema factors of anthrax toxin bind only to oligomeric forms of the protective antigen

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3105081

5 July 2018

Matrix Metalloproteinase Inhibitors and Cancer--Trials and Tribulations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3105081

5 July 2018

Stoichiometry of anthrax toxin complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3105081

5 July 2018

Identification of the cellular receptor for anthrax toxin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3105081

5 July 2018

The microenvironment of the tumour-host interface

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3105081

5 July 2018

Cancer cell expression of urokinase-type plasminogen activator receptor mRNA in squamous cell carcinomas of the skin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3105081

5 July 2018

Susceptibility of mitogen-activated protein kinase kinase family members to proteolysis by anthrax lethal factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3105081

5 July 2018

Anthrax lethal factor cleaves the N-terminus of MAPKKs and induces tyrosine/threonine phosphorylation of MAPKs in cultured macrophages

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3105081

5 July 2018

Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3105081

5 July 2018

Growth and dissemination of Lewis lung carcinoma in plasminogen-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3105081

5 July 2018

Expression of collagenase-3 (matrix metalloproteinase-13) in squamous cell carcinomas of the head and neck

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3105081

5 July 2018

Cathepsin B and D expression in squamous cell carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3105081

5 July 2018

Residues 1-254 of anthrax toxin lethal factor are sufficient to cause cellular uptake of fused polypeptides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3105081

5 July 2018

Membrane-type matrix metalloproteinase (MT-MMP) gene is expressed in stromal cells of human colon, breast, and head and neck carcinomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3105081

5 July 2018

Tyrosine phosphorylation as a marker for aberrantly regulated growth-promoting pathways in cell lines derived from head and neck malignancies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3105081

5 July 2018

Anthrax toxin edema factor: a bacterial adenylate cyclase that increases cyclic AMP concentrations of eukaryotic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3105081

5 July 2018

Two new human tumor cell lines derived from squamous cell carcinomas of the tongue: establishment, characterization and response to cytotoxic treatment.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3105081

5 July 2018

Human furin is a calcium-dependent serine endoprotease that recognizes the sequence Arg-X-X-Arg and efficiently cleaves anthrax toxin protective antigen

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3105081

5 July 2018

Anthrax toxin protective antigen is activated by a cell surface protease with the sequence specificity and catalytic properties of furin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3105081

5 July 2018

Expression of matrix metalloproteinase 1, matrix metalloproteinase 2, and matrix metalloproteinase 9 in carcinoma of the head and neck.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0020532

21 January 2018

Targeting of tumor cells by cell surface urokinase plasminogen activator-dependent anthrax toxin

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0020532

21 January 2018

Tumor cell-selective cytotoxicity of matrix metalloproteinase-activated anthrax toxin

1 reference

https://pubmed.ncbi.nlm.nih.gov/21655226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of tissue inhibitor of matrix metalloproteinase-2 correlates with activation of matrix metalloproteinase-2 and predicts poor prognosis in tongue squamous cell carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/21655226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Urokinase-type plasminogen activator, plasminogen activator inhibitor type 1 and cathepsin D: analysis of their prognostic significance in squamous cell carcinoma of the head and neck

1 reference

https://pubmed.ncbi.nlm.nih.gov/21655226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MMP and TIMP gene expression in head and neck squamous cell carcinomas and adjacent tissues

1 reference

https://pubmed.ncbi.nlm.nih.gov/21655226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Head and neck cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/21655226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunohistology of the Antigenic Pattern of a Continuous Cell Line From a Human Colon Tumor

1 reference

https://pubmed.ncbi.nlm.nih.gov/21655226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasminogen activators in human xenografted oro-pharyngeal squamous cell carcinomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/21655226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased stromelysin 3 gene expression is associated with increased local invasiveness in head and neck squamous cell carcinomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/21655226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of matrix metalloproteinase-2 related to lymph node metastasis of oral squamous cell carcinoma. A clinicopathologic study

1 reference

https://pubmed.ncbi.nlm.nih.gov/21655226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of expression of matrix metalloproteinases-2 and -9 in hypopharyngeal squamous cell carcinoma by in situ hybridization

1 reference

https://pubmed.ncbi.nlm.nih.gov/21655226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lysosomal proteases cathepsins D, B, H, L and their inhibitors stefins A and B in head and neck cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/21655226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prognostic value of cathepsins B, H, L, D and their endogenous inhibitors stefins A and B in head and neck carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/21655226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relationship between head and neck squamous cell carcinomas and fibrinolytic factors. Immunohistological study

1 reference

https://pubmed.ncbi.nlm.nih.gov/21655226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Localization of plasminogen activators and their inhibitor in squamous cell carcinomas of the head and neck

1 reference

https://pubmed.ncbi.nlm.nih.gov/21655226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cancer invasion and tissue remodeling: common themes in proteolytic matrix degradation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21655226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies in a tumor spectrum. III. The effect of phosphoramides on the growth of a variety of mouse and rat tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/21655226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Systemic anthrax lethal toxin therapy produces regressions of subcutaneous human melanoma tumors in athymic nude mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/21655226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Systematic urokinase-activated anthrax toxin therapy produces regressions of subcutaneous human non-small cell lung tumor in athymic nude mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/21655226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased levels of urokinase receptor in plasma of head and neck squamous cell carcinoma patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/21655226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Optimized production and purification of Bacillus anthracis lethal factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/21655226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Urokinase receptor up-regulation in head and neck squamous cell carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/21655226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical significance of expression of membrane type 1 matrix metalloproteinase and matrix metalloproteinase-2 in human head and neck squamous cell carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/21655226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0020532

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

2011PLoSO...620532S

0 references

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

ResearchGate publication ID

0 references

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