(Q33927792)

30 July 2017

title

Functionally important conformations of the Met20 loop in dihydrofolate reductase are populated by rapid thermal fluctuations (English)

1 reference

30 July 2017

Karunesh Arora

1

1 reference

30 July 2017

Charles L Brooks Iii

series ordinal

2

1 reference

30 July 2017

language of work or name

English

0 references

publication date

1 April 2009

1 reference

Journal of the American Chemical Society

30 July 2017

published in

1 reference

30 July 2017

volume

131

1 reference

30 July 2017

issue

15

1 reference

30 July 2017

page(s)

5642-5647

1 reference

All-atom empirical potential for molecular modeling and dynamics studies of proteins

30 July 2017

cites work

1 reference

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Conformational relaxation following hydride transfer plays a limiting role in dihydrofolate reductase catalysis

5 July 2018

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Dynamic energy landscape view of coupled binding and protein conformational change: induced-fit versus population-shift mechanisms

5 July 2018

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Effects of pressure on enzyme function of Escherichia coli dihydrofolate reductase

5 July 2018

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Large-scale allosteric conformational transitions of adenylate kinase appear to involve a population-shift mechanism

5 July 2018

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Conformational change of the methionine 20 loop of Escherichia coli dihydrofolate reductase modulates pKa of the bound dihydrofolate

5 July 2018

1 reference

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The dynamic energy landscape of dihydrofolate reductase catalysis

5 July 2018

1 reference

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Multiple-basin energy landscapes for large-amplitude conformational motions of proteins: Structure-based molecular dynamics simulations

5 July 2018

1 reference

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Defining the role of active-site loop fluctuations in dihydrofolate reductase catalysis

5 July 2018

1 reference

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Conformational changes in the active site loops of dihydrofolate reductase during the catalytic cycle.

5 July 2018

1 reference

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A perspective on enzyme catalysis.

5 July 2018

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How dihydrofolate reductase facilitates protonation of dihydrofolate

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889193

5 July 2018

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Role of water in the catalytic cycle of E. coli dihydrofolate reductase

5 July 2018

1 reference

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Network of coupled promoting motions in enzyme catalysis

5 July 2018

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Backbone dynamics in dihydrofolate reductase complexes: role of loop flexibility in the catalytic mechanism

5 July 2018

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Interloop contacts modulate ligand cycling during catalysis by Escherichia coli dihydrofolate reductase

5 July 2018

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Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence

5 July 2018

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A perspective on biological catalysis

5 July 2018

1 reference

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In search of dihydrofolate reductase

5 July 2018

1 reference

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Construction and evaluation of the kinetic scheme associated with dihydrofolate reductase from Escherichia coli

5 July 2018

1 reference

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Insights into enzyme function from studies on mutants of dihydrofolate reductase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889193

The function of amino acid residues contacting the nicotinamide ring of NADPH in dihydrofolate reductase from Escherichia coli

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889193

Allosteric communication in dihydrofolate reductase: signaling network and pathways for closed to occluded transition and back

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889193

Insight into the role of hydration on protein dynamics.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889193

Conformational substates modulate hydride transfer in dihydrofolate reductase.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889193

The coupling of structural fluctuations to hydride transfer in dihydrofolate reductase

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889193

Improved treatment of the protein backbone in empirical force fields.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889193

Effect of cofactor binding and loop conformation on side chain methyl dynamics in dihydrofolate reductase

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889193

Diagnostic chemical shift markers for loop conformation and substrate and cofactor binding in dihydrofolate reductase complexes

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889193

New analytic approximation to the standard molecular volume definition and its application to generalized Born calculations.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889193

Coupling interactions of distal residues enhance dihydrofolate reductase catalysis: mutational effects on hydride transfer rates

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889193

Identification of a protein-promoting vibration in the reaction catalyzed by horse liver alcohol dehydrogenase

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889193

High pressure NMR reveals active-site hinge motion of folate-bound Escherichia coli dihydrofolate reductase.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889193

Dynamics of the dihydrofolate reductase-folate complex: catalytic sites and regions known to undergo conformational change exhibit diverse dynamical features

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889193

Diffusive Model of Protein Folding Dynamics with Kramers Turnover in Rate

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889193

Conformational Diffusion and Helix Formation Kinetics

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889193

Free Energy Landscape of A-DNA to B-DNA Conversion in Aqueous Solution

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889193

Evidence for a functional role of the dynamics of glycine-121 of Escherichia coli dihydrofolate reductase obtained from kinetic analysis of a site-directed mutant

10 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19323547

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Deletion of a highly motional residue affects formation of the Michaelis complex for Escherichia coli dihydrofolate reductase

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19323547

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Two-state allosteric behavior in a single-domain signaling protein

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19323547

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/JA9000135

1 reference

30 July 2017

1 reference

30 July 2017

1 reference