(Q33928601)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15738420%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

title

Disrupting integrin transmembrane domain heterodimerization increases ligand binding affinity, not valency or clustering (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15738420%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

main subject

transmembrane protein

0 references

ligand binding

1 reference

protein heterodimerization activity

inferred from title

1 reference

inferred from title

author

Christopher V. Carman

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15738420%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

author name string

Bing-Hao Luo

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15738420%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

Junichi Takagi

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15738420%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

Timothy A Springer

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15738420%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

language of work or name

English

0 references

publication date

28 February 2005

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15738420%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

number of pages

6

1 reference

Proceedings of the National Academy of Sciences of the United States of America

inferred from page(s)

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15738420%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

volume

102

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15738420%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

issue

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15738420%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

page(s)

3679-3684

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15738420%20AND%20SRC:MED&resulttype=core&format=json

The primacy of affinity over clustering in regulation of adhesiveness of the integrin {alpha}L{beta}2.

9 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553322

Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553322

Dimerization of the transmembrane domain of Integrin alphaIIb subunit in cell membranes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553322

Periodic lamellipodial contractions correlate with rearward actin waves

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553322

Integrin avidity regulation: are changes in affinity and conformation underemphasized?

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553322

Stabilizing the open conformation of the integrin headpiece with a glycan wedge increases affinity for ligand

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553322

Integrins: bidirectional, allosteric signaling machines

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553322

Mechanisms contributing to the activity of integrins on leukocytes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553322

Integrin activation and structural rearrangement

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553322

A structural mechanism of integrin alpha(IIb)beta(3) "inside-out" activation as regulated by its cytoplasmic face

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553322

Integrin activation takes shape

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553322

Marching at the front and dragging behind: differential alphaVbeta3-integrin turnover regulates focal adhesion behavior

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553322

Oligomerization of the integrin alphaIIbbeta3: roles of the transmembrane and cytoplasmic domains

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553322

Green fluorescent protein (GFP) tagged to the cytoplasmic tail of alphaIIb or beta3 allows the expression of a fully functional integrin alphaIIb(beta3): effect of beta3GFP on alphaIIb(beta3) ligand binding

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553322

Differential dynamics of alpha 5 integrin, paxillin, and alpha-actinin during formation and disassembly of adhesions in migrating cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553322

The actin cytoskeleton regulates LFA-1 ligand binding through avidity rather than affinity changes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553322

Are changes in integrin affinity and conformation overemphasized?

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553322

A novel regulatory epitope defined by a murine monoclonal antibody to the platelet GPIIb-IIIa complex (alpha IIb beta 3 integrin).

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553322

Breaking the integrin hinge. A defined structural constraint regulates integrin signaling

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553322

Adhesion-activating phorbol ester increases the mobility of leukocyte integrin LFA-1 in cultured lymphocytes.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553322

Long range propagation of conformational changes in integrin alpha IIb beta 3.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553322

Determinants of specificity of a baculovirus-expressed antibody Fab fragment that binds selectively to the activated form of integrin alpha IIb beta 3.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553322

Redistribution of the fibrinogen receptor of human platelets after surface activation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553322

The platelet fibrinogen receptor: an immunogold-surface replica study of agonist-induced ligand binding and receptor clustering

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553322

Analysis of mutation in human cells by using an Epstein-Barr virus shuttle system

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553322

Molecular cloning and chemical synthesis of a region of platelet glycoprotein IIb involved in adhesive function

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553322

Sequence specificity in the dimerization of transmembrane alpha-helices

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=553322

Global conformational rearrangements in integrin extracellular domains in outside-in and inside-out signaling

5 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0409440102

Bidirectional transmembrane signaling by cytoplasmic domain separation in integrins

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0409440102

Activation of integrin alphaIIbbeta3 by modulation of transmembrane helix associations

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0409440102

Detection of integrin alpha IIbbeta 3 clustering in living cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0409440102

Allosteric beta1 integrin antibodies that stabilize the low affinity state by preventing the swing-out of the hybrid domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0409440102

Colloidal gold labelling of fibrinogen receptors in epinephrine- and ADP-activated platelet suspensions

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15738420

12 December 2020

inferred from PubMed ID database lookup

Expression of ligand-induced binding sites on glycoprotein IIb/IIIa complexes and the effect of various inhibitors

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15738420

12 December 2020

inferred from PubMed ID database lookup

Chemokines trigger immediate beta2 integrin affinity and mobility changes: differential regulation and roles in lymphocyte arrest under flow

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15738420

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1073/PNAS.0409440102

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15738420%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15738420%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

PubMed publication ID

15738420

1 reference