(Q33931868)

30 July 2017

title

Age-dependent vulnerability to endotoxemia is associated with reduction of anticoagulant factors activated protein C and thrombomodulin (English)

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30 July 2017

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6

B Mark Evers

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30 July 2017

Marlene E Starr

1

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30 July 2017

Junji Ueda

2

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30 July 2017

Hitoshi Takahashi

3

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30 July 2017

Hartmut Weiler

4

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30 July 2017

Charles T Esmon

5

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30 July 2017

Hiroshi Saito

7

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30 July 2017

language of work or name

English

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publication date

26 March 2010

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30 July 2017

number of pages

8

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inferred from page(s)

published in

Blood

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30 July 2017

volume

115

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30 July 2017

issue

23

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30 July 2017

page(s)

4886-4893

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Extracellular histones are major mediators of death in sepsis

30 July 2017

cites work

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Age-associated increase in cytokine production during systemic inflammation: adipose tissue as a major source of IL-6

5 July 2018

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5 July 2018

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5 July 2018

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Inflammation and the activated protein C anticoagulant pathway

5 July 2018

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5 July 2018

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5 July 2018

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Kruppel-like factor 2 (KLF2) regulates endothelial thrombotic function

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Aging accelerates endotoxin-induced thrombosis : increased responses of plasminogen activator inhibitor-1 and lipopolysaccharide signaling with aging

5 July 2018

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Myeloid zinc finger (MZF)-like, Kruppel-like and Ets families of transcription factors determine the cell-specific expression of mouse extracellular superoxide dismutase

5 July 2018

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New mechanisms for vascular control of inflammation mediated by natural anticoagulant proteins

5 July 2018

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Intra-abdominal Sepsis in Elderly Persons

5 July 2018

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5 July 2018

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Age-associated differences in cardiovascular inflammatory gene induction during endotoxic stress.

5 July 2018

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A targeted point mutation in thrombomodulin generates viable mice with a prethrombotic state

5 July 2018

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The endothelial cell protein C receptor augments protein C activation by the thrombin-thrombomodulin complex.

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Tumor necrosis factor suppresses transcription of the thrombomodulin gene in endothelial cells

5 July 2018

1 reference

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Structure and function of thrombomodulin: a natural anticoagulant

5 July 2018

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5 July 2018

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Influence of TNF-alpha and biomechanical stress on endothelial anti- and prothrombotic genes

5 July 2018

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29 October 2018

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Kruppel-like factor 4 regulates endothelial inflammation.

29 October 2018

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Overexpressing endothelial cell protein C receptor alters the hemostatic balance and protects mice from endotoxin.

29 October 2018

1 reference

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Factor V Leiden polymorphism modifies sepsis outcome: evidence from animal studies

29 October 2018

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Thrombomodulin mutant mice with a strongly reduced capacity to generate activated protein C have an unaltered pulmonary immune response to respiratory pathogens and lipopolysaccharide

29 October 2018

1 reference

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Capillary endothelial thrombomodulin expression and fibrin deposition in rats with continuous and bolus lipopolysaccharide administration.

29 October 2018

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Drotrecogin alfa (activated) treatment of older patients with severe sepsis

29 October 2018

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Activated protein C inhibits lipopolysaccharide-induced tumor necrosis factor-alpha production by inhibiting activation of both nuclear factor-kappa B and activator protein-1 in human monocytes.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890181

Dysfunction of Endothelial Protein C Activation in Severe Meningococcal Sepsis

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890181

Regulation of endothelial thrombomodulin expression by inflammatory cytokines is mediated by activation of nuclear factor-kappa B

29 October 2018

1 reference

12 December 2020

A Comparative Study of the Protein C Pathway in Septic and Nonseptic Patients with Organ Failure

1 reference

12 December 2020

Protective effects of activated protein C in sepsis

1 reference

12 December 2020

Disseminated intravascular coagulation

1 reference

12 December 2020

Characterization of a mouse model for thrombomodulin deficiency

1 reference

12 December 2020

Bacterial lipopolysaccharide decreases thrombomodulin expression in the sinusoidal endothelial cells of rats -- a possible mechanism of intrasinusoidal microthrombus formation and liver dysfunction

1 reference

12 December 2020

Age-associated differences in TNF-alpha and nitric oxide production in endotoxic mice

1 reference

12 December 2020

Systemic inflammatory response syndrome

1 reference

12 December 2020

Patients with severe sepsis vary markedly in their ability to generate activated protein C

1 reference

12 December 2020

Effects of aging on mortality, hypothermia, and cytokine induction in mice with endotoxemia or sepsis

1 reference

12 December 2020

10.1182/BLOOD-2009-10-246678

Identifiers

DOI

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30 July 2017

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30 July 2017

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