(Q33935634)

30 July 2017

title

TGF-β mediates early angiogenesis and latent fibrosis in an Emilin1-deficient mouse model of aortic valve disease (English)

1 reference

Elastin microfibril interfacer 1

30 July 2017

0 references

1 reference

GOA release 2020-03-11

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Charu Munjal

1

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30 July 2017

Amy M Opoka

2

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30 July 2017

Hanna Osinska

3

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30 July 2017

Jeanne F James

4

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30 July 2017

Giorgio M Bressan

5

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30 July 2017

Robert B Hinton

6

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30 July 2017

publication date

1 August 2014

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Disease Models & Mechanisms

30 July 2017

published in

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30 July 2017

volume

7

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30 July 2017

issue

8

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30 July 2017

page(s)

987-996

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describes a project that uses

30 July 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4107327/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Elastogenesis at the onset of human cardiac valve development

5 July 2018

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Cadherin-11 regulates cell-cell tension necessary for calcific nodule formation by valvular myofibroblasts

5 July 2018

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Bicuspid aortic valve and thoracic aortic aneurysm: three patient populations, two disease phenotypes, and one shared genotype

5 July 2018

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5-HT(2B) antagonism arrests non-canonical TGF-β1-induced valvular myofibroblast differentiation

5 July 2018

1 reference

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The role of extracellular signal-related kinase during abdominal aortic aneurysm formation

5 July 2018

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Pooled analyses of the associations of polymorphisms in the GRK4 and EMILIN1 genes with hypertension risk

5 July 2018

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5 July 2018

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Maladaptive matrix remodeling and regional biomechanical dysfunction in a mouse model of aortic valve disease.

5 July 2018

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New evidence for a critical role of elastin in calcification of native heart valves: immunohistochemical and ultrastructural study with literature review.

5 July 2018

1 reference

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Calcific aortic valve disease: not simply a degenerative process: A review and agenda for research from the National Heart and Lung and Blood Institute Aortic Stenosis Working Group. Executive summary: Calcific aortic valve disease-2011 update.

5 July 2018

1 reference

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EMILIN1-α4/α9 integrin interaction inhibits dermal fibroblast and keratinocyte proliferation.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107327

Recruitment of bone marrow-derived valve interstitial cells is a normal homeostatic process

5 July 2018

1 reference

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Inflammatory regulation of valvular remodeling: the good(?), the bad, and the ugly

5 July 2018

1 reference

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Differential expression of cartilage and bone-related proteins in pediatric and adult diseased aortic valves

5 July 2018

1 reference

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Networked-based characterization of extracellular matrix proteins from adult mouse pulmonary and aortic valves.

5 July 2018

1 reference

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The response to valve injury. A paradigm to understand the pathogenesis of heart valve disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107327

Heart Valve Structure and Function in Development and Disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107327

Developmental basis of adult cardiovascular diseases: valvular heart diseases

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107327

Emilin1 gene and essential hypertension: a two-stage association study in northern Han Chinese population

5 July 2018

1 reference

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VEGF and RANKL regulation of NFATc1 in heart valve development.

5 July 2018

1 reference

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Aging in inbred strains of mice: study design and interim report on median lifespans and circulating IGF1 levels

5 July 2018

1 reference

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Vascular extracellular matrix and arterial mechanics

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107327

Role of the MAPK/ERK pathway in valvular interstitial cell calcification

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107327

Echocardiographic assessment of valve stenosis: EAE/ASE recommendations for clinical practice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107327

Evolving concepts of cardiac valve dynamics: the continuum of development, functional structure, pathobiology, and tissue engineering

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107327

Mouse heart valve structure and function: echocardiographic and morphometric analyses from the fetus through the aged adult.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107327

Human pulmonary valve progenitor cells exhibit endothelial/mesenchymal plasticity in response to vascular endothelial growth factor-A and transforming growth factor-beta2.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107327

Emilin1 links TGF-beta maturation to blood pressure homeostasis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107327

Calcified rheumatic valve neoangiogenesis is associated with vascular endothelial growth factor expression and osteoblast-like bone formation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107327

TGF-beta-dependent pathogenesis of mitral valve prolapse in a mouse model of Marfan syndrome

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107327

EMILIN-1 deficiency induces elastogenesis and vascular cell defects

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107327

Temporal and distinct TGFbeta ligand requirements during mouse and avian endocardial cushion morphogenesis.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107327

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107327

Aortic valve endothelial cells undergo transforming growth factor-beta-mediated and non-transforming growth factor-beta-mediated transdifferentiation in vitro

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107327

Second natural history study of congenital heart defects. Results of treatment of patients with aortic valvar stenosis.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107327

Presence of a smooth muscle system in aortic valve leaflets

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107327

Interstitial cells of the heart valves possess characteristics similar to smooth muscle cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107327

Association of aortic dilation with regurgitant, stenotic and functionally normal bicuspid aortic valves

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107327

An EMILIN1-negative microenvironment promotes tumor cell proliferation and lymph node invasion.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107327

Elastin haploinsufficiency results in progressive aortic valve malformation and latent valve disease in a mouse model

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107327

Screening for aortic root dilation in marfan syndrome using the ratio of the aortic root to descending aortic diameters in children.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107327

Perturbations of vascular homeostasis and aortic valve abnormalities in fibulin-4 deficient mice.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107327

Elastin-derived peptides enhance angiogenesis by promoting endothelial cell migration and tubulogenesis through upregulation of MT1-MMP.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107327

Dynamic and reversible changes of interstitial cell phenotype during remodeling of cardiac valves.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107327

Valvular myofibroblast activation by transforming growth factor-beta: implications for pathological extracellular matrix remodeling in heart valve disease.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107327

Novel effects of neutrophil-derived proteinase 3 and elastase on the vascular endothelium involve in vivo cleavage of NF-kappaB and proapoptotic changes in JNK, ERK, and p38 MAPK signaling pathways

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107327

Outcomes 15 years after valve replacement with a mechanical versus a bioprosthetic valve: final report of the Veterans Affairs randomized trial

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107327

ACC/AHA/ASE 2003 Guideline Update for the Clinical Application of Echocardiography: Summary Article: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (ACC/AHA/ASE Committee to Update the 1997

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107327

Aortic valve structure-function correlations: role of elastic fibers no longer a stretch of the imagination

29 October 2018

1 reference

12 December 2020

The role of elastin in aortic valve mechanics

1 reference

12 December 2020

Expression of the EMILIN-1 gene during mouse development

1 reference

12 December 2020

Vascular endothelial growth factor-secreting mast cells and myofibroblasts: a novel self-perpetuating angiogenic pathway in aortic valve stenosis

1 reference

12 December 2020

The vascularization of the heart valves: a comparative study

1 reference

12 December 2020

Extracellular Matrix Remodeling and Organization in Developing and Diseased Aortic Valves

1 reference

12 December 2020

Patterns of calcific deposits in operatively excised stenotic or purely regurgitant aortic valves and their relation to mechanical stress

1 reference

12 December 2020

Burden of valvular heart diseases: a population-based study

1 reference

12 December 2020

Extracellular matrix remodelling in human aortic valve disease: the role of matrix metalloproteinases and their tissue inhibitors

1 reference

12 December 2020

Identifiers

DOI

10.1242/DMM.015255

1 reference

30 July 2017

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30 July 2017

1 reference