(Q33937973)

English

The late increase in intracellular free radical oxygen species during apoptosis is associated with cytochrome c release, caspase activation, and mitochondrial dysfunction.

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scholarly article

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2 November 2019

The late increase in intracellular free radical oxygen species during apoptosis is associated with cytochrome c release, caspase activation, and mitochondrial dysfunction (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12700632%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

apoptotic process

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Alexandru Almasan

7

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2 November 2019

author name string

Q Chen

1

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2 November 2019

Y-C Chai

2

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2 November 2019

S Mazumder

3

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2 November 2019

C Jiang

4

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2 November 2019

R M Macklis

5

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2 November 2019

G M Chisolm

6

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2 November 2019

publication date

1 March 2003

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2 November 2019

Cell Death & Differentiation

1 reference

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2 November 2019

10

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2 November 2019

3

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2 November 2019

323-334

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2 November 2019

https://scigraph.springernature.com/pub.10.1038/sj.cdd.4401148

0 references

Requirement for caspase-2 in stress-induced apoptosis before mitochondrial permeabilization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1196205

5 July 2018

Regulation and measurement of oxidative stress in apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1196205

5 July 2018

Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1196205

5 July 2018

Role of glutathione depletion and reactive oxygen species generation in apoptotic signaling in a human B lymphoma cell line.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1196205

5 July 2018

Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1196205

5 July 2018

Cytochrome c release from mitochondria proceeds by a two-step process

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1196205

5 July 2018

The expanding role of mitochondria in apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1196205

5 July 2018

Apo2L/TRAIL and Bcl-2-related proteins regulate type I interferon-induced apoptosis in multiple myeloma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1196205

5 July 2018

Endonuclease G is an apoptotic DNase when released from mitochondria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1196205

5 July 2018

Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1196205

5 July 2018

Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1196205

5 July 2018

Distinct stages of cytochrome c release from mitochondria: evidence for a feedback amplification loop linking caspase activation to mitochondrial dysfunction in genotoxic stress induced apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1196205

5 July 2018

The coordinate release of cytochrome c during apoptosis is rapid, complete and kinetically invariant

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1196205

5 July 2018

Bcl-2 proteins: regulators of apoptosis or of mitochondrial homeostasis?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1196205

5 July 2018

BCL-2 and glutathione: alterations in cellular redox state that regulate apoptosis sensitivity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1196205

5 July 2018

p53 regulates mitochondrial membrane potential through reactive oxygen species and induces cytochrome c-independent apoptosis blocked by Bcl-2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1196205

5 July 2018

BCL-2 family members and the mitochondria in apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1196205

5 July 2018

Mitochondrial disease in superoxide dismutase 2 mutant mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1196205

5 July 2018

Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1196205

5 July 2018

Caspases: enemies within

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1196205

5 July 2018

The regulation of reactive oxygen species production during programmed cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1196205

5 July 2018

Bcl-2 expression causes redistribution of glutathione to the nucleus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1196205

5 July 2018

Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1196205

5 July 2018

Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1196205

5 July 2018

A model for p53-induced apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1196205

5 July 2018

Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1196205

5 July 2018

The central executioner of apoptosis: multiple connections between protease activation and mitochondria in Fas/APO-1/CD95- and ceramide-induced apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1196205

5 July 2018

Glutathione depletion is an early and calcium elevation is a late event of thymocyte apoptosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1196205

5 July 2018

The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1196205

5 July 2018

Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1196205

5 July 2018

Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1196205

5 July 2018

The Bcl-2 oncoprotein functions as a pro-oxidant.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1196205

5 July 2018

Alterations in mitochondrial structure and function are early events of dexamethasone-induced thymocyte apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1196205

5 July 2018

Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1196205

5 July 2018

Direct evidence for tumor necrosis factor-induced mitochondrial reactive oxygen intermediates and their involvement in cytotoxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1196205

5 July 2018

The role of intracellular oxidants in apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1196205

5 July 2018

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1196205

5 July 2018

The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1196205

5 July 2018

Induction of manganous superoxide dismutase by tumor necrosis factor: possible protective mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1196205

5 July 2018

Caspase-2 acts upstream of mitochondria to promote cytochrome c release during etoposide-induced apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1196205

29 October 2018

A study on permeability transition pore opening and cytochrome c release from mitochondria, induced by caspase-3 in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1196205

29 October 2018

Programmed cell death and Bcl-2 protection in very low oxygen.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1196205

29 October 2018

Bcl-2 and Bcl-XL can differentially block chemotherapy-induced cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/12700632

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Superoxide in apoptosis. Mitochondrial generation triggered by cytochrome c loss

1 reference

https://pubmed.ncbi.nlm.nih.gov/12700632

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The central executioners of apoptosis: caspases or mitochondria?

1 reference

https://pubmed.ncbi.nlm.nih.gov/12700632

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of reactive oxygen species-induced apoptosis and necrosis by caspase 3-like proteases

1 reference

https://pubmed.ncbi.nlm.nih.gov/12700632

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ionizing radiation-induced, Bax-mediated cell death is dependent on activation of cysteine and serine proteases

1 reference

https://pubmed.ncbi.nlm.nih.gov/12700632

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/SJ.CDD.4401148

1 reference

Europe PubMed Central

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2 November 2019

1 reference

Europe PubMed Central

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2 November 2019

1 reference

Europe PubMed Central

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2 November 2019

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