(Q33938398)

30 July 2017

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title

Apolipoprotein E receptors: linking brain development and Alzheimer's disease (English)

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30 July 2017

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J Herz

1

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30 July 2017

U Beffert

series ordinal

2

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30 July 2017

language of work or name

English

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publication date

1 October 2000

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Nature Reviews Neuroscience

30 July 2017

published in

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30 July 2017

volume

1

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30 July 2017

issue

1

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30 July 2017

page(s)

51-58

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Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins

30 July 2017

cites work

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7 January 2021

Role of apolipoprotein E in modulating neurite outgrowth: potential effect of intracellular apolipoprotein E.

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7 January 2021

A role for apolipoprotein E, apolipoprotein A-I, and low density lipoprotein receptors in cholesterol transport during regeneration and remyelination of the rat sciatic nerve

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7 January 2021

Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease

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7 January 2021

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

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Alpha-2 macroglobulin is genetically associated with Alzheimer disease

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7 January 2021

Evidence that the newly cloned low-density-lipoprotein receptor related protein (LRP) is the alpha 2-macroglobulin receptor

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7 January 2021

Genetic association of the low-density lipoprotein receptor-related protein gene (LRP), an apolipoprotein E receptor, with late-onset Alzheimer's disease

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7 January 2021

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Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery

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Normal plasma lipoproteins and fertility in gene-targeted mice homozygous for a disruption in the gene encoding very low density lipoprotein receptor

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Defective forebrain development in mice lacking gp330/megalin

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Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2

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An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3

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Structures and functions of multiligand lipoprotein receptors: macrophage scavenger receptors and LDL receptor-related protein (LRP).

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7 January 2021

The low-density lipoprotein receptor gene family: multiple roles in lipid metabolism

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7 January 2021

Lipoprotein receptors: new roles for ancient proteins.

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Reelin is a secreted glycoprotein recognized by the CR-50 monoclonal antibody.

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Mutant mice with scrambled brains: understanding the signaling pathways that control cell positioning in the CNS.

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Aberrant splicing of a mouse disabled homolog, mdab1, in the scrambler mouse

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Scrambler and yotari disrupt the disabled gene and produce a reeler-like phenotype in mice

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7 January 2021

Neuronal position in the developing brain is regulated by mouse disabled-1

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7 January 2021

Two new mutants, ‘trembler’ and ‘reeler’, with neurological actions in the house mouse (Mus musculus L.)

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Direct binding of Reelin to VLDL receptor and ApoE receptor 2 induces tyrosine phosphorylation of disabled-1 and modulates tau phosphorylation

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7 January 2021

Reelin is a ligand for lipoprotein receptors

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7 January 2021

Reelin-induced tyrosine [corrected] phosphorylation of disabled 1 during neuronal positioning

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7 January 2021

Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein

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7 January 2021

Signaling through scaffold, anchoring, and adaptor proteins

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7 January 2021

Association of a novel human FE65-like protein with the cytoplasmic domain of the beta-amyloid precursor protein

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7 January 2021

cDNA cloning and chromosome mapping of the human Fe65 gene: interaction of the conserved cytoplasmic domains of the human beta-amyloid precursor protein and its homologues with the mouse Fe65 protein

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7 January 2021

Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction

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7 January 2021

The disabled 1 phosphotyrosine-binding domain binds to the internalization signals of transmembrane glycoproteins and to phospholipids

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7 January 2021

Proteins of the CNR family are multiple receptors for Reelin

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7 January 2021

Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures, and adult lethality

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7 January 2021

Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death

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7 January 2021

Cyclin-dependent kinase 5-deficient mice demonstrate novel developmental arrest in cerebral cortex

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7 January 2021

The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation

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7 January 2021

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

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7 January 2021

The reelin receptor ApoER2 recruits JNK-interacting proteins-1 and -2

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7 January 2021

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7 January 2021

Modulation of beta-amyloid precursor protein processing by the low density lipoprotein receptor-related protein (LRP). Evidence that LRP contributes to the pathogenesis of Alzheimer's disease.

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7 January 2021

Translating cell biology into therapeutic advances in Alzheimer's disease

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Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

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Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

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7 January 2021

Purification and cloning of amyloid precursor protein beta-secretase from human brain

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7 January 2021

Cleavage of Alzheimer's amyloid precursor protein by alpha-secretase occurs at the surface of neuronal cells

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7 January 2021

Regulation of macrophage alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein by lipopolysaccharide and interferon-gamma

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7 January 2021

Head injury, amyloid β and Alzheimer's disease

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7 January 2021

hFE65L influences amyloid precursor protein maturation and secretion

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7 January 2021

Regulation of beta-amyloid secretion by FE65, an amyloid protein precursor-binding protein

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7 January 2021

The Fe65 adaptor protein interacts through its PID1 domain with the transcription factor CP2/LSF/LBP1

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7 January 2021

Molecular cloning and characterization of the human glycogen synthase kinase-3beta promoter

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7 January 2021

Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line

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7 January 2021

Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro

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7 January 2021

Stable expression and secretion of apolipoproteins E3 and E4 in mouse neuroblastoma cells produces differential effects on neurite outgrowth

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7 January 2021

Degradation of amyloid beta-protein by a serine protease-alpha2-macroglobulin complex

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7 January 2021

Effects of the amyloid protein precursor of Alzheimer's disease and other ligands of the LDL receptor-related protein on neurite outgrowth from sympathetic neurons in culture

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7 January 2021

The low density lipoprotein receptor gene family. Differential expression of two alpha2-macroglobulin receptors in the brain

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7 January 2021

Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition

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7 January 2021

Apolipoprotein E-epsilon 2 and Alzheimer's disease: genotype influences pathologic phenotype.

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7 January 2021

Altered microtubule organization in small-calibre axons of mice lacking tau protein

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7 January 2021

Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17.

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7 January 2021

Age-Dependent Emergence and Progression of a Tauopathy in Transgenic Mice Overexpressing the Shortest Human Tau Isoform

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7 January 2021

Phosphorylation of tau in apolipoprotein E-deficient mice

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7 January 2021

Role of Tissue Plasminogen Activator Receptor LRP in Hippocampal Long-Term Potentiation

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7 January 2021

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

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7 January 2021

A receptor-mediated pathway for cholesterol homeostasis

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7 January 2021

Surface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptor

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7 January 2021

Human apolipoprotein E receptor 2. A novel lipoprotein receptor of the low density lipoprotein receptor family predominantly expressed in brain

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7 January 2021

Complete cloning and sequencing of rat gp330/"megalin," a distinctive member of the low density lipoprotein receptor gene family

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7 January 2021

Rabbit very low density lipoprotein receptor: a low density lipoprotein receptor-like protein with distinct ligand specificity

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7 January 2021

A new low density lipoprotein receptor homologue with 8 ligand binding repeats in brain of chicken and mouse

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7 January 2021

The Drosophila yolkless gene encodes a vitellogenin receptor belonging to the low density lipoprotein receptor superfamily

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7 January 2021

Comparative genomics of the eukaryotes

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7 January 2021

The WW domain of neural protein FE65 interacts with proline-rich motifs in Mena, the mammalian homolog of Drosophila enabled

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7 January 2021

Mutations in Drosophila enabled and rescue by human vasodilator-stimulated phosphoprotein (VASP) indicate important functional roles for Ena/VASP homology domain 1 (EVH1) and EVH2 domains

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7 January 2021

Genetic suppression of mutations in the Drosophila abl proto-oncogene homolog

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7 January 2021

Dosage-sensitive modifiers of Drosophila abl tyrosine kinase function: prospero, a regulator of axonal outgrowth, and disabled, a novel tyrosine kinase substrate.

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7 January 2021

Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics

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7 January 2021

Mena is required for neurulation and commissure formation

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7 January 2021

The JIP group of mitogen-activated protein kinase scaffold proteins

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7 January 2021

Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

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7 January 2021

Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor

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7 January 2021

The polymorphism in exon 3 of the low density lipoprotein receptor-related protein gene is weakly associated with Alzheimer's disease.

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7 January 2021

The regions of the Fe65 protein homologous to the phosphotyrosine interaction/phosphotyrosine binding domain of Shc bind the intracellular domain of the Alzheimer's amyloid precursor protein

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7 January 2021

The human FE65 gene: genomic structure and an intronic biallelic polymorphism associated with sporadic dementia of the Alzheimer type

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7 January 2021

Fine mapping of the chromosome 12 late-onset Alzheimer disease locus: potential genetic and phenotypic heterogeneity

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7 January 2021

Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein

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7 January 2021

Identifiers

DOI

10.1038/35036221

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Dimensions Publication ID

30 July 2017

1018866968

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