(Q33939096)

30 July 2017

title

Small molecule amiloride modulates oncogenic RNA alternative splicing to devitalize human cancer cells (English)

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alternative mRNA splicing, via spliceosome

30 July 2017

main subject

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1 reference

Jan-Gowth Chang

1

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30 July 2017

Den-Mei Yang

2

1 reference

30 July 2017

Wen-Hsin Chang

3

1 reference

30 July 2017

Lu-Ping Chow

4

1 reference

30 July 2017

Wen-Ling Chan

5

1 reference

30 July 2017

Hui-Hua Lin

6

1 reference

30 July 2017

Hsien-Da Huang

7

1 reference

30 July 2017

Ya-Sian Chang

8

1 reference

30 July 2017

Cheng-Hao Hung

9

1 reference

30 July 2017

Wen-Kuang Yang

10

1 reference

30 July 2017

language of work or name

English

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publication date

9 June 2011

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30 July 2017

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30 July 2017

volume

6

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30 July 2017

issue

6

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30 July 2017

page(s)

e18643

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Creative Commons Attribution 4.0 International

30 July 2017

copyright license

start time

9 June 2011

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April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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Genome-wide analysis of alternative pre-mRNA splicing

5 July 2018

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5-(N-ethyl-N-isopropyl)-amiloride enhances SMN2 exon 7 inclusion and protein expression in spinal muscular atrophy cells

5 July 2018

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Splicing in disease: disruption of the splicing code and the decoding machinery

5 July 2018

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Alternative splicing: an emerging topic in molecular and clinical oncology

5 July 2018

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MEME: discovering and analyzing DNA and protein sequence motifs

5 July 2018

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The connection between splicing and cancer.

5 July 2018

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Evidence for subcomplexes in the Fanconi anemia pathway

5 July 2018

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Unbalanced alternative splicing and its significance in cancer

5 July 2018

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Cell motility is controlled by SF2/ASF through alternative splicing of the Ron protooncogene

5 July 2018

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Structural and functional diversity generated by alternative mRNA splicing.

5 July 2018

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Regulation of apoptosis by alternative pre-mRNA splicing

5 July 2018

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Understanding alternative splicing: towards a cellular code

5 July 2018

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Silencers regulate both constitutive and alternative splicing events in mammals

5 July 2018

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Cross-talk between signaling pathways regulates alternative splicing: a novel role for JNK.

5 July 2018

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RS domains contact the pre-mRNA throughout spliceosome assembly

5 July 2018

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Molecular and genetic studies imply Akt-mediated signaling promotes protein kinase CbetaII alternative splicing via phosphorylation of serine/arginine-rich splicing factor SRp40

5 July 2018

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Function of alternative splicing

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3111415

Amiloride augments TRAIL-induced apoptotic death by inhibiting phosphorylation of kinases and phosphatases associated with the P13K-Akt pathway

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3111415

GO::TermFinder--open source software for accessing Gene Ontology information and finding significantly enriched Gene Ontology terms associated with a list of genes

5 July 2018

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A molecular link between SR protein dephosphorylation and mRNA export

5 July 2018

1 reference

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The epithelial sodium channel in hypertension: genetic heterogeneity and implications for treatment with amiloride

5 July 2018

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WebLogo: A Sequence Logo Generator

5 July 2018

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Dissection of the mammalian midbody proteome reveals conserved cytokinesis mechanisms.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3111415

IFN-beta induces caspase-mediated apoptosis by disrupting mitochondria in human advanced stage colon cancer cell lines.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3111415

Immortalization without neoplastic transformation of human mesenchymal stem cells by transduction with HPV16 E6/E7 genes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3111415

JNK regulates HIPK3 expression and promotes resistance to Fas-mediated apoptosis in DU 145 prostate carcinoma cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3111415

Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3111415

The UCSC Table Browser data retrieval tool

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3111415

DAVID: Database for Annotation, Visualization, and Integrated Discovery

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3111415

Mechanisms of alternative pre-messenger RNA splicing

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3111415

Alternative pre-mRNA splicing and proteome expansion in metazoans

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3111415

Alternative splicing: multiple control mechanisms and involvement in human disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3111415

The protein kinase Clk/Sty directly modulates SR protein activity: both hyper- and hypophosphorylation inhibit splicing

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3111415

The subcellular localization of SF2/ASF is regulated by direct interaction with SR protein kinases (SRPKs)

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3111415

Both phosphorylation and dephosphorylation of ASF/SF2 are required for pre-mRNA splicing in vitro

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3111415

Serine/threonine phosphatase 1 modulates the subnuclear distribution of pre-mRNA splicing factors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3111415

A serine kinase regulates intracellular localization of splicing factors in the cell cycle

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3111415

The superfamily of arginine/serine-rich splicing factors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3111415

Selective expression of CD44 messenger RNA splice variants in four high grade human brain tumour cell lines.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3111415

Amiloride directly inhibits growth factor receptor tyrosine kinase activity.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3111415

Expression and role of Bcl-xL in human hepatocellular carcinomas

5 July 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0018643

Truncated RON tyrosine kinase drives tumor cell progression and abrogates cell-cell adhesion through E-cadherin transcriptional repression

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0018643

Phosphorylation of the ASF/SF2 RS domain affects both protein-protein and protein-RNA interactions and is necessary for splicing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0018643

Phosphorylation-dependent and -independent nuclear import of RS domain-containing splicing factors and regulators.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0018643

Tumor invasiveness and liver metastasis of colon cancer cells correlated with cyclooxygenase-2 (COX-2) expression and inhibited by a COX-2-selective inhibitor, etodolac.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0018643

Subcellular and functional proteomic analysis of the cellular responses induced by Helicobacter pylori.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0018643

Detection and measurement of alternative splicing using splicing-sensitive microarrays.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0018643

Protein phosphatase 1 can modulate alternative 5′ splice site selection in a HeLa splicing extract

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0018643

Co-expression and regulation of Met and Ron proto-oncogenes in human hepatocellular carcinoma tissues and cell lines

21 January 2018

1 reference

12 December 2020

Concerted regulation of nuclear and cytoplasmic activities of SR proteins by AKT

1 reference

12 December 2020

Characterization of CD133+ hepatocellular carcinoma cells as cancer stem/progenitor cells

1 reference

12 December 2020

Amiloride modulates alternative splicing in leukemic cells and resensitizes Bcr-AblT315I mutant cells to imatinib

1 reference

12 December 2020

Amiloride. A potassium-sparing natriuretic agent

1 reference

12 December 2020

Properties of the K562 cell line derived from a patient with chronic myeloid leukemia

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0018643

Identifiers

DOI

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30 July 2017

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30 July 2017

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