(Q33944072)

30 July 2017

title

High throughput screening of a library based on kinase inhibitor scaffolds against Mycobacterium tuberculosis H37Rv (English)

1 reference

Mycobacterium tuberculosis

30 July 2017

main subject

0 references

author name string

Robert C Reynolds

1

1 reference

30 July 2017

Subramaniam Ananthan

2

1 reference

30 July 2017

Ellen Faaleolea

3

1 reference

30 July 2017

Judith V Hobrath

4

1 reference

30 July 2017

Cecil D Kwong

5

1 reference

30 July 2017

Clinton Maddox

6

1 reference

30 July 2017

Lynn Rasmussen

7

1 reference

30 July 2017

Melinda I Sosa

8

1 reference

30 July 2017

Elizabeth Thammasuvimol

9

1 reference

30 July 2017

E Lucile White

10

1 reference

30 July 2017

Wei Zhang

11

1 reference

30 July 2017

John A Secrist

12

1 reference

30 July 2017

publication date

25 June 2011

1 reference

30 July 2017

1 reference

30 July 2017

volume

92

1 reference

30 July 2017

issue

1

1 reference

30 July 2017

page(s)

72-83

1 reference

Division and cell envelope regulation by Ser/Thr phosphorylation: Mycobacterium shows the way.

30 July 2017

cites work

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5 July 2018

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The inhibitor of cyclin-dependent kinases, olomoucine II, exhibits potent antiviral properties.

5 July 2018

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The nuts and bolts of AGC protein kinases

5 July 2018

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Rho-associated kinase II (ROCKII) limits axonal growth after trauma within the adult mouse spinal cord

5 July 2018

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Benzothiazoles as Rho-associated kinase (ROCK-II) inhibitors

5 July 2018

1 reference

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Antituberculosis activity of the molecular libraries screening center network library

5 July 2018

1 reference

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High-throughput screening for inhibitors of Mycobacterium tuberculosis H37Rv

5 July 2018

1 reference

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Identification of N-(5-tert-butyl-isoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea dihydrochloride (AC220), a uniquely potent, selective, and efficacious FMS-like tyrosine kinase-3 (FLT3) inhibitor

5 July 2018

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Discovery and validation of new antitubercular compounds as potential drug leads and probes

5 July 2018

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Uncovering new signaling proteins and potential drug targets through the interactome analysis of Mycobacterium tuberculosis

5 July 2018

1 reference

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Discovery of 2-(5-nitrothiazol-2-ylthio)benzo[d]thiazoles as novel c-Jun N-terminal kinase inhibitors

5 July 2018

1 reference

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Protein-drug interaction studies for development of drugs against Plasmodium falciparum.

5 July 2018

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Targeting cancer with small molecule kinase inhibitors

5 July 2018

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Small molecule p38 MAP kinase inhibitors for the treatment of inflammatory diseases: novel structures and developments during 2006-2008.

5 July 2018

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Discovery of 2-amino-6-carboxamidobenzothiazoles as potent Lck inhibitors

5 July 2018

1 reference

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Benzothiazole based inhibitors of p38alpha MAP kinase

5 July 2018

1 reference

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A novel drug discovery concept for tuberculosis: inhibition of bacterial and host cell signalling.

5 July 2018

1 reference

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Structure-activity relationships of novel heteroaryl-acrylonitriles as cytotoxic and antibacterial agents.

5 July 2018

1 reference

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Synthesis of amide and urea derivatives of benzothiazole as Raf-1 inhibitor.

5 July 2018

1 reference

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EmbR2, a structural homologue of EmbR, inhibits the Mycobacterium tuberculosis kinase/substrate pair PknH/EmbR

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183257

Mycobacterial Ser/Thr protein kinases and phosphatases: physiological roles and therapeutic potential.

5 July 2018

1 reference

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Synthesis of some novel thiourea derivatives obtained from 5-[(4-aminophenoxy)methyl]-4-alkyl/aryl-2,4-dihydro-3H-1,2,4-triazole-3-thiones and evaluation as antiviral/anti-HIV and anti-tuberculosis agents

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183257

Protein kinases as targets for antiparasitic chemotherapy drugs.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183257

Molecular recognition of protein kinase binding pockets for design of potent and selective kinase inhibitors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183257

Tyrosine phosphorylation: an emerging regulatory device of bacterial physiology

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183257

Structure/function studies of Ser/Thr and Tyr protein phosphorylation in Mycobacterium tuberculosis

5 July 2018

1 reference

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Ser/Thr/Tyr protein phosphorylation in bacteria - for long time neglected, now well established

5 July 2018

1 reference

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Second-generation kinase inhibitors

5 July 2018

1 reference

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Kinomics: characterizing the therapeutically validated kinase space.

5 July 2018

1 reference

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Strategies for the design of potent and selective kinase inhibitors.

5 July 2018

1 reference

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A comprehensive update of the sequence and structure classification of kinases

5 July 2018

1 reference

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Inhibition of Yersinia tyrosine phosphatase by furanyl salicylate compounds

5 July 2018

1 reference

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Interplay between mycobacteria and host signalling pathways

5 July 2018

1 reference

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Recent kinase and kinase inhibitor X-ray structures: mechanisms of inhibition and selectivity insights

5 July 2018

1 reference

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Kinomics-structural biology and chemogenomics of kinase inhibitors and targets

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183257

Cyclin-dependent kinases as cellular targets for antiviral drugs

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183257

Sequence and structure classification of kinases

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183257

Strategies toward the design of novel and selective protein tyrosine kinase inhibitors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183257

Microplate alamar blue assay versus BACTEC 460 system for high-throughput screening of compounds against Mycobacterium tuberculosis and Mycobacterium avium

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183257

Reactions of cyanomethylbenzimidazoles. Part III. Reaction of cyanomethylbenzimidazoles with isocyanates and isothiocyanates

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183257

Synthesis and antimicrobial activity of some novel oxadiazole derivatives

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183257

2-Thiazolylimino/heteroarylimino-5-arylidene-4-thiazolidinones as new agents with SHP-2 inhibitory action

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183257

ATP competitive inhibitors of D-alanine-D-alanine ligase based on protein kinase inhibitor scaffolds

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183257

Synthesis of new 4-pyrrol-1-yl benzoic acid hydrazide analogs and some derived oxadiazole, triazole and pyrrole ring systems: a novel class of potential antibacterial and antitubercular agents

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183257

Three-dimensional quantitative structure-activity relationship (3 D-QSAR) and docking studies on (benzothiazole-2-yl) acetonitrile derivatives as c-Jun N-terminal kinase-3 (JNK3) inhibitors.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183257

Synthesis and antimycobacterial activity of some alkyl [5-(nitroaryl)-1,3,4-thiadiazol-2-ylthio]propionates

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183257

Design and synthesis of the first generation of novel potent, selective, and in vivo active (benzothiazol-2-yl)acetonitrile inhibitors of the c-Jun N-terminal kinase.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183257

Antimycobacterial activity of new 3-substituted 5-(pyridin-4-yl)-3H-1,3,4-oxadiazol-2-one and 2-thione derivatives. Preliminary molecular modeling investigations

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183257

Synthesis and tuberculostatic activity of some (4-phenylpiperazin-1-ylmethyl)-1,3,4-oxadiazole and (4-phenylpiperazin-1-ylmethyl)-1,2,4-triazole derivatives.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183257

Synthesis and antiproliferative activity of 3-aryl-2-(1H-benzotriazol-1-yl)acrylonitriles. Part III.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183257

Synthesis and antitubercular activity of 3-aryl substituted-2-[1H(2H)benzotriazol-1(2)-yl]acrylonitriles

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183257

Reactions of cyanomethylbenzimidazoles. Part II. Reaction of cyanomethylbenzimidazoles with aldehydes methylketones and nitroso compounds

29 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21708485

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Synthesis and some reactions of 2-cyanomethylimidazo [4,5-b]pyridine. Tuberculostatic investigations of obtained compounds

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21708485

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

[Synthesis and tuberculostatic activity of reaction products 5-(2-,3- and 4-pyridil) -1,3,4-oxadiazol-2-thione with amines]

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21708485

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.TUBE.2011.05.005

1 reference

30 July 2017

1 reference

30 July 2017

1 reference