(Q33952214)

30 July 2017

title

An observational cohort study of the kynurenine to tryptophan ratio in sepsis: association with impaired immune and microvascular function (English)

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30 July 2017

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7

Nicholas M Anstey

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30 July 2017

Christabelle J Darcy

1

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30 July 2017

Joshua S Davis

2

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30 July 2017

Tonia Woodberry

3

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30 July 2017

Yvette R McNeil

4

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30 July 2017

Dianne P Stephens

5

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30 July 2017

Tsin W Yeo

6

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30 July 2017

language of work or name

English

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publication date

22 June 2011

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30 July 2017

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30 July 2017

volume

6

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30 July 2017

issue

6

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30 July 2017

page(s)

e21185

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Creative Commons Attribution 4.0 International

30 July 2017

copyright license

start time

22 June 2011

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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SOCS3 drives proteasomal degradation of indoleamine 2,3-dioxygenase (IDO) and antagonizes IDO-dependent tolerogenesis

5 July 2018

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Upregulation of indoleamine 2,3-dioxygenase in hepatitis C virus infection

5 July 2018

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HIV inhibits CD4+ T-cell proliferation by inducing indoleamine 2,3-dioxygenase in plasmacytoid dendritic cells

5 July 2018

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Cutting edge: human eosinophils regulate T cell subset selection through indoleamine 2,3-dioxygenase

5 July 2018

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Assessment of peripheral vascular endothelial function with finger arterial pulse wave amplitude.

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120841

Peripheral distribution of kynurenine metabolites and activity of kynurenine pathway enzymes in renal failure.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120841

Decreased tryptophan catabolism by placental indoleamine 2,3-dioxygenase in preeclampsia

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120841

The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome

5 July 2018

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Tryptophan availability selectively limits NO-synthase induction in macrophages.

5 July 2018

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5 July 2018

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Tryptophan deprivation sensitizes activated T cells to apoptosis prior to cell division

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120841

Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120841

Serum tryptophan decrease correlates with immune activation and impaired quality of life in colorectal cancer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120841

Functional expression of indoleamine 2,3-dioxygenase by murine CD8 alpha(+) dendritic cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120841

Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120841

Enhanced tryptophan degradation in systemic lupus erythematosus

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120841

Cytokine mediated regulation of interferon-gamma-induced IDO activation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120841

Prevention of lymphocyte cell death in sepsis improves survival in mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120841

Inhibition of T cell proliferation by macrophage tryptophan catabolism

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120841

Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units: results of a multicenter, prospective study. Working group on "sepsis-related problems" of the European Society of Intensive Care Medicine.

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120841

Interferon-gamma-induced activation of indoleamine 2,3-dioxygenase in cord blood monocyte-derived macrophages inhibits the growth of group B streptococci

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120841

Inhibition of nitric oxide synthase expression and activity in macrophages by 3-hydroxyanthranilic acid, a tryptophan metabolite

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120841

Role of granulocyte colony-stimulating factor in the immune response to acute bacterial infection in the nonneutropenic host: an overview

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120841

Induction of pulmonary indoleamine 2,3-dioxygenase by interferon

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120841

Physiological studies of tryptophan transport and tryptophanase operon induction in Escherichia coli

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120841

Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120841

Adult-population incidence of severe sepsis in Australian and New Zealand intensive care units.

5 July 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0021185

Brain serotonin content: physiological dependence on plasma tryptophan levels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0021185

Upregulation of indoleamine 2,3-dioxygenase in hepatocyte during acute hepatitis caused by hepatitis B virus-specific cytotoxic T lymphocytes in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0021185

Proapoptotic activity of indoleamine 2,3-dioxygenase expressed in renal tubular epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0021185

Potential regulatory function of human dendritic cells expressing indoleamine 2,3-dioxygenase

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0021185

T cell apoptosis by tryptophan catabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0021185

Arginine, citrulline and nitric oxide metabolism in sepsis

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0021185

Human endothelial impairment in sepsis

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0021185

Kynurenines and oxidative status are independently associated with thrombomodulin and von Willebrand factor levels in patients with end-stage renal disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0021185

Randomized, double-blind, placebo-controlled trial of granulocyte colony-stimulating factor in patients with septic shock

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0021185

Effective antiretroviral therapy reduces degradation of tryptophan in patients with HIV-1 infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0021185

Assessment of peripheral vascular endothelial function in the ambulatory setting.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0021185

Influenza-induced expression of indoleamine 2,3-dioxygenase enhances interleukin-10 production and bacterial outgrowth during secondary pneumococcal pneumonia

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0021185

Sputum indoleamine-2, 3-dioxygenase activity is increased in asthmatic airways by using inhaled corticosteroids

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0021185

Co-operative action of interleukin-10 and interferon-gamma to regulate dendritic cell functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0021185

IFN-gamma amplifies IL-6 and IL-8 responses by airway epithelial-like cells via indoleamine 2,3-dioxygenase

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0021185

Inverse correlation between tumoral indoleamine 2,3-dioxygenase expression and tumor-infiltrating lymphocytes in endometrial cancer: its association with disease progression and survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0021185

Caspase inhibitors improve survival in sepsis: a critical role of the lymphocyte

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0021185

Akt decreases lymphocyte apoptosis and improves survival in sepsis

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0021185

Skin cells, but not T cells, are resistant to indoleamine 2, 3-dioxygenase (IDO) expressed by allogeneic fibroblasts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0021185

Increased serum kynurenine/tryptophan ratio correlates with disease progression in lung cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0021185

Enhanced indoleamine 2,3-dioxygenase activity in patients with severe sepsis and septic shock.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0021185

Treatment with granulocyte-macrophage colony-stimulating factor is associated with reduced indoleamine 2,3-dioxygenase activity and kynurenine pathway catabolites in patients with severe sepsis and septic shock.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0021185

High activity of indoleamine 2,3 dioxygenase enzyme predicts disease severity and case fatality in bacteremic patients.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120841

The combined effects of tryptophan starvation and tryptophan catabolites down-regulate T cell receptor zeta-chain and induce a regulatory phenotype in naive T cells

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120841

Enhanced enzymatic degradation of tryptophan by indoleamine 2,3-dioxygenase contributes to the tryptophan-deficient state seen after major trauma.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120841

Serotonin-immune interactions in elderly volunteers and in patients with Alzheimer's disease (DAT): lower plasma tryptophan availability to the brain in the elderly and increased serum interleukin-6 in DAT.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120841

Correlations between endotoxin, interferon-gamma, biopterin and serum phospholipase A2-activities during lethal gram negative sepsis in rats.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3120841

Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction

29 October 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0021185

Reliable endothelial function testing: at our fingertips?

21 January 2018

1 reference

12 December 2020

Bim siRNA decreases lymphocyte apoptosis and improves survival in sepsis

1 reference

12 December 2020

Tryptophane as Precursor of Nicotinamide in Mammals

1 reference

12 December 2020

Reduced citrulline production in sepsis is related to diminished de novo arginine and nitric oxide production

1 reference

12 December 2020

Early circulating lymphocyte apoptosis in human septic shock is associated with poor outcome

1 reference

12 December 2020

Relationships between lower plasma L-tryptophan levels and immune-inflammatory variables in depression

1 reference

12 December 2020

Serum kynurenine-to-tryptophan ratio increases with progressive disease in HIV-infected patients

1 reference

12 December 2020

Prolonged lymphopenia, lymphoid depletion, and hypoprolactinemia in children with nosocomial sepsis and multiple organ failure

1 reference

12 December 2020

In vivo arginine production and intravascular nitric oxide synthesis in hypotensive sepsis

1 reference

12 December 2020

Interactions between nitric oxide and indoleamine 2,3-dioxygenase

1 reference

12 December 2020

Interferon-induced indoleamine 2,3-dioxygenase activity in human mononuclear phagocytes

1 reference

12 December 2020

Tryptophan metabolism and indoleamine 2,3-dioxygenase expression in coeliac disease

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0021185

Identifiers

DOI

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30 July 2017

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30 July 2017

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