(Q33952921)

30 July 2017

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title

Sp1 and krüppel-like factor family of transcription factors in cell growth regulation and cancer (English)

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30 July 2017

Black AR

1

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30 July 2017

Black JD

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2

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30 July 2017

Azizkhan-Clifford J

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3

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30 July 2017

language of work or name

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1 August 2001

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Journal of Cellular Physiology

30 July 2017

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30 July 2017

188

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30 July 2017

143-160

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30 July 2017

2

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Positive- and negative-acting Kruppel-like transcription factors bind a transforming growth factor beta control element required for expression of the smooth muscle cell differentiation marker SM22alpha in vivo.

30 July 2017

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p21(WAF1/CIP1) is upregulated by the geranylgeranyltransferase I inhibitor GGTI-298 through a transforming growth factor beta- and Sp1-responsive element: involvement of the small GTPase rhoA.

21 January 2018

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Cyclin D1 associates with the TBP-associated factor TAF(II)250 to regulate Sp1-mediated transcription

21 January 2018

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Follicle stimulating hormone-regulated expression of serum/glucocorticoid-inducible kinase in rat ovarian granulosa cells: a functional role for the Sp1 family in promoter activity

21 January 2018

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Neu differentiation factor stimulates phosphorylation and activation of the Sp1 transcription factor

21 January 2018

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Sp3 is a transcriptional repressor of transforming growth factor-beta receptors

21 January 2018

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DNA damage and the DNA-activated protein kinase

21 January 2018

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High Sp1/Sp3 ratios in epithelial cells during epithelial differentiation and cellular transformation correlate with the activation of the HPV-16 promoter.

21 January 2018

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FKLF, a novel Krüppel-like factor that activates human embryonic and fetal beta-like globin genes

21 January 2018

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Transcriptional factors for specific globin genes.

21 January 2018

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Sp1 and Sp3 regulate expression of the neuronal nicotinic acetylcholine receptor beta4 subunit gene.

21 January 2018

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p53 regulates caveolin gene transcription, cell cholesterol, and growth by a novel mechanism

21 January 2018

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Protein kinase C-mediated regulation of the cell cycle

21 January 2018

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Regulation of E2F: a family of transcription factors involved in proliferation control

21 January 2018

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Growth/cell cycle regulation of Sp1 phosphorylation

21 January 2018

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Transcriptional initiation is controlled by upstream GC-box interactions in a TATAA-less promoter

21 January 2018

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A putative binding site for Sp1 is involved in transcriptional regulation of CYP17 gene expression in bovine ovary

21 January 2018

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Transcription factor Sp3 is essential for post-natal survival and late tooth development

21 January 2018

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Efficient TGF-beta induction of the Smad7 gene requires cooperation between AP-1, Sp1, and Smad proteins on the mouse Smad7 promoter

21 January 2018

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A zinc-finger transcription factor induced by TGF-beta promotes apoptotic cell death in epithelial Mv1Lu cells

21 January 2018

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Cooperation of E2F-p130 and Sp1-pRb complexes in repression of the Chinese hamster dhfr gene

21 January 2018

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Functional interaction between c-Jun and promoter factor Sp1 in epidermal growth factor-induced gene expression of human 12(S)-lipoxygenase

21 January 2018

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The retinoblastoma gene product RB stimulates Sp1-mediated transcription by liberating Sp1 from a negative regulator

21 January 2018

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Modulation of human alpha1(I) procollagen gene activity by interaction with Sp1 and Sp3 transcription factors in vitro

21 January 2018

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Transcriptional regulation of endothelial nitric-oxide synthase by an interaction between casein kinase 2 and protein phosphatase 2A.

21 January 2018

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Up-regulation of endothelial nitric-oxide synthase promoter by the phosphatidylinositol 3-kinase gamma /Janus kinase 2/MEK-1-dependent pathway

21 January 2018

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Sp1 binding is inhibited by (m)Cp(m)CpG methylation.

21 January 2018

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A gene encoding an intestinal-enriched member of the Krüppel-like factor family expressed in intestinal epithelial cells

21 January 2018

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Insulin-like growth factor-I regulates transcription of the elastin gene through a putative retinoblastoma control element. A role for Sp3 acting as a repressor of elastin gene transcription.

21 January 2018

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Molecular cloning and characterization of TIEG2 reveals a new subfamily of transforming growth factor-beta-inducible Sp1-like zinc finger-encoding genes involved in the regulation of cell growth

21 January 2018

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Synergistic activation by the glutamine-rich domains of human transcription factor Sp1

21 January 2018

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Isolation and characterization of the cDNA encoding BKLF/TEF-2, a major CACCC-box-binding protein in erythroid cells and selected other cells

21 January 2018

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Novel role for Sp1 in phorbol ester enhancement of human platelet thromboxane receptor gene expression

21 January 2018

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Decreased expression of the gut-enriched Krüppel-like factor gene in intestinal adenomas of multiple intestinal neoplasia mice and in colonic adenomas of familial adenomatous polyposis patients

21 January 2018

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The biology of the mammalian Krüppel-like family of transcription factors

21 January 2018

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Association of p107 with Sp1: genetically separable regions of p107 are involved in regulation of E2F- and Sp1-dependent transcription

21 January 2018

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Regulation of plasminogen activator inhibitor-1 expression by transforming growth factor-beta -induced physical and functional interactions between smads and Sp1.

21 January 2018

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Basic transcription element-binding protein (BTEB) is a thyroid hormone-regulated gene in the developing central nervous system. Evidence for a role in neurite outgrowth.

21 January 2018

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HPV16 E6 oncoprotein stimulates the transforming growth factor-beta 1 promoter in fibroblasts through a specific GC-rich sequence

21 January 2018

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Mechanisms of transcriptional activation of bcl-2 gene expression by 17beta-estradiol in breast cancer cells

21 January 2018

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Control of eukaryotic messenger RNA synthesis by sequence-specific DNA-binding proteins.

21 January 2018

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Stimulation of dihydrofolate reductase promoter activity by antimetabolic drugs

21 January 2018

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Transforming growth factor-beta1 induces interleukin-6 expression via activating protein-1 consisting of JunD homodimers in primary human lung fibroblasts.

21 January 2018

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GLUT1 glucose transporter gene transcription is repressed by Sp3. Evidence for a regulatory role of Sp3 during myogenesis.

21 January 2018

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TGFbeta-inducible early gene (TIEG) also codes for early growth response alpha (EGRalpha): evidence of multiple transcripts from alternate promoters.

21 January 2018

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Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15(Ink4B) transcription in response to TGF-beta

21 January 2018

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Sp1 recognition sites in the proximal promoter of the human vascular endothelial growth factor gene are essential for platelet-derived growth factor-induced gene expression

21 January 2018

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Protein kinase C signaling mediates a program of cell cycle withdrawal in the intestinal epithelium

21 January 2018

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A retinoblastoma susceptibility gene product, RB, targeting protease is regulated through the cell cycle

21 January 2018

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The regulation of cyclin D1 expression in senescent human fibroblasts.

21 January 2018

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Protein phosphatase 2A and phosphatidylinositol 3-kinase regulate the activity of Sp1-responsive promoters

21 January 2018

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A gene for a novel zinc-finger protein expressed in differentiated epithelial cells and transiently in certain mesenchymal cells

21 January 2018

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Transactivation and growth suppression by the gut-enriched Krüppel-like factor (Krüppel-like factor 4) are dependent on acidic amino acid residues and protein-protein interaction

21 January 2018

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Function of fibroblast growth factors and vascular endothelial growth factors and their receptors in angiogenesis

21 January 2018

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The same nuclear proteins bind the proximal CACCC box of the human beta-globin promoter and a similar sequence in the enhancer

21 January 2018

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Tumor necrosis factor-alpha regulates expression of vascular endothelial growth factor receptor-2 and of its co-receptor neuropilin-1 in human vascular endothelial cells.

21 January 2018

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B-lymphocyte quiescence, tolerance and activation as viewed by global gene expression profiling on microarrays

21 January 2018

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Tyrosine dephosphorylation of nuclear proteins mimics transforming growth factor beta 1 stimulation of alpha 2(I) collagen gene expression

21 January 2018

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Sp1 is required for the early response of alpha2(I) collagen to transforming growth factor-beta1.

21 January 2018

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A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening

21 January 2018

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Cloning by recognition site screening of two novel GT box binding proteins: a family of Sp1 related genes

21 January 2018

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Functional analyses of the transcription factor Sp4 reveal properties distinct from Sp1 and Sp3

21 January 2018

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Modulation of Sp1 activity by a cyclin A/CDK complex

21 January 2018

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Mitotic arrest with nocodazole induces selective changes in the level of O-linked N-acetylglucosamine and accumulation of incompletely processed N-glycans on proteins from HT29 cells

21 January 2018

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Modulation of O-linked N-acetylglucosamine levels on nuclear and cytoplasmic proteins in vivo using the peptide O-GlcNAc-beta-N-acetylglucosaminidase inhibitor O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino-N-phenylcarbamate

21 January 2018

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Reduced O glycosylation of Sp1 is associated with increased proteasome susceptibility

21 January 2018

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21 January 2018

The Hallmarks of Cancer

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Sp5, a new member of the Sp1 family, is dynamically expressed during development and genetically interacts with Brachyury

21 January 2018

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Transcription factors Sp1 and Sp3 alter vascular endothelial growth factor receptor expression through a novel recognition sequence

21 January 2018

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Overexpression of a nuclear protein, TIEG, mimics transforming growth factor-beta action in human osteoblast cells

21 January 2018

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Regulated expression of the BTEB2 transcription factor in vascular smooth muscle cells: analysis of developmental and pathological expression profiles shows implications as a predictive factor for restenosis

21 January 2018

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Structure and expression of the promoter for the human type II transforming growth factor-beta receptor.

21 January 2018

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Molecular cloning and functional analysis of the murine bax gene promoter

21 January 2018

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Overlapping pathways mediate the opposing actions of tumor necrosis factor-alpha and transforming growth factor-beta on alpha 2(I) collagen gene transcription

21 January 2018

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O-glycosylation of eukaryotic transcription factors: implications for mechanisms of transcriptional regulation

21 January 2018

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GC box binding induces phosphorylation of Sp1 by a DNA-dependent protein kinase

21 January 2018

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Distinct roles for Sp1 and E2F sites in the growth/cell cycle regulation of the DHFR promoter

21 January 2018

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pRB induces Sp1 activity by relieving inhibition mediated by MDM2.

21 January 2018

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Multiple protein-DNA interactions in the TATAA-less mouse thymidylate synthase promoter

21 January 2018

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Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain

21 January 2018

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c-Jun transactivates the promoter of the human p21(WAF1/Cip1) gene by acting as a superactivator of the ubiquitous transcription factor Sp1.

21 January 2018

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Interaction of Sp1 with the growth- and cell cycle-regulated transcription factor E2F

21 January 2018

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Sp3 encodes multiple proteins that differ in their capacity to stimulate or repress transcription

21 January 2018

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The retinoblastoma gene product regulates Sp1-mediated transcription

21 January 2018

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Transcriptional activation of transforming growth factor beta1 and its receptors by the Kruppel-like factor Zf9/core promoter-binding protein and Sp1. Potential mechanisms for autocrine fibrogenesis in response to injury.

21 January 2018

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Cloning of GT box-binding proteins: a novel Sp1 multigene family regulating T-cell receptor gene expression

21 January 2018

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Ras induces p21Cip1/Waf1 cyclin kinase inhibitor transcriptionally through Sp1-binding sites

21 January 2018

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Serum responsive gene expression mediated by Sp1.

21 January 2018

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Enhanced Sp1 DNA-binding activity in murine keratinocyte cell lines and epidermal tumors

21 January 2018

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The LKLF transcription factor is required for normal tunica media formation and blood vessel stabilization during murine embryogenesis

21 January 2018

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Identification and characterization of the putative retinoblastoma control element of the rat insulin-like growth factor binding protein-2 gene

21 January 2018

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Sp3 and Sp4 can repress transcription by competing with Sp1 for the core cis-elements on the human ADH5/FDH minimal promoter

21 January 2018

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Transforming growth factor-beta up-regulates the beta 5 integrin subunit expression via Sp1 and Smad signaling.

21 January 2018

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Initial sequencing and analysis of the human genome

21 January 2018

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Cyclin D1 is required for transformation by activated Neu and is induced through an E2F-dependent signaling pathway

21 January 2018

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Activation of the insulin-like growth factor II transcription by aflatoxin B1 induced p53 mutant 249 is caused by activation of transcription complexes; implications for a gain-of-function during the formation of hepatocellular carcinoma

21 January 2018

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The core promoter region of the tumor necrosis factor alpha gene confers phorbol ester responsiveness to upstream transcriptional activators.

21 January 2018

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Transforming growth factor beta activates the promoter of cyclin-dependent kinase inhibitor p15INK4B through an Sp1 consensus site

21 January 2018

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Sp1, but not Sp3, functions to mediate promoter activation by TGF-beta through canonical Sp1 binding sites

21 January 2018

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Cell cycle-regulated association of E2F1 and Sp1 is related to their functional interaction

21 January 2018

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Transcriptional activation of human 12-lipoxygenase gene promoter is mediated through Sp1 consensus sites in A431 cells

21 January 2018

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The role of Sp1 in the differential expression of transforming growth factor-beta receptor type II in human breast adenocarcinoma MCF-7 cells

21 January 2018

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Effects of three Sp1 motifs on the transcription of the FGF-4 gene

21 January 2018

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Characterization of the structure and regulation of the murine gene encoding gut-enriched Krüppel-like factor (Krüppel-like factor 4).

21 January 2018

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Sequence analysis of the promoter region of the glioblastoma derived T cell suppressor factor/transforming growth factor (TGF)-beta 2 gene reveals striking differences to the TGF-beta 1 and -beta 3 genes

21 January 2018

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BRCA1 suppresses insulin-like growth factor-I receptor promoter activity: potential interaction between BRCA1 and Sp1.

21 January 2018

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Transcription factor Sp1 is essential for early embryonic development but dispensable for cell growth and differentiation

21 January 2018

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Cloning the cDNA for a new human zinc finger protein defines a group of closely related Krüppel-like transcription factors

21 January 2018

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Constitutive Fas ligand gene transcription in Sertoli cells is regulated by Sp1.

21 January 2018

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Epidermal growth factor stimulation of the human gastrin promoter requires Sp1.

21 January 2018

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p42/p44 MAP kinase module plays a key role in the transcriptional regulation of the vascular endothelial growth factor gene in fibroblasts

21 January 2018

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Role of nitric oxide in cancer biology

21 January 2018

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Epidermal growth factor and okadaic acid stimulate Sp1 proteolysis

21 January 2018

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The von Hippel-Lindau tumor suppressor gene product interacts with Sp1 to repress vascular endothelial growth factor promoter activity

21 January 2018

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A unique cathepsin-like protease isolated from CV-1 cells is involved in rapid degradation of retinoblastoma susceptibility gene product, RB, and transcription factor SP1.

21 January 2018

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Cell-growth regulation of the hamster dihydrofolate reductase gene promoter by transcription factor Sp1.

21 January 2018

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The Krüppel-like transcriptional factors Zf9 and GKLF coactivate the human keratin 4 promoter and physically interact

21 January 2018

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Regulation of erythroid Krüppel-like factor (EKLF) transcriptional activity by phosphorylation of a protein kinase casein kinase II site within its interaction domain.

21 January 2018

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Role of protein kinase Czeta in Ras-mediated transcriptional activation of vascular permeability factor/vascular endothelial growth factor expression

21 January 2018

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GKLF in thymus epithelium as a developmentally regulated element of thymocyte-stroma cross-talk

21 January 2018

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Role of Smad proteins and transcription factor Sp1 in p21(Waf1/Cip1) regulation by transforming growth factor-beta.

21 January 2018

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Sp1 mediates constitutive and transforming growth factor beta-inducible expression of urokinase type plasminogen activator receptor gene in human monocyte-like U937 cells

21 January 2018

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Activator protein-2 mediates transcriptional activation of the CYP11A1 gene by interaction with Sp1 rather than binding to DNA.

21 January 2018

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Molecular cloning and characterization of the cyclic AMP-responsive ovine CYP11A1 (cholesterol side-chain cleavage) gene promoter: DNase 1 protection of conserved consensus elements

21 January 2018

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A tale of three fingers: the family of mammalian Sp/XKLF transcription factors

21 January 2018

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Retinoid-induced apoptosis and Sp1 cleavage occur independently of transcription and require caspase activation

21 January 2018

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Sp1 and Smad proteins cooperate to mediate transforming growth factor-beta 1-induced alpha 2(I) collagen expression in human glomerular mesangial cells

21 January 2018

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Transcription from a TATA-less promoter requires a multisubunit TFIID complex

21 January 2018

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Bcl-3 expression promotes cell survival following interleukin-4 deprivation and is controlled by AP1 and AP1-like transcription factors

21 January 2018

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The transforming growth factor beta(1)-inducible transcription factor TIEG1, mediates apoptosis through oxidative stress

21 January 2018

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Cleavage of transcription factor SP1 by caspases during anti-IgM-induced B-cell apoptosis

21 January 2018

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NF-kappaB inhibits expression of the alpha1(I) collagen gene.

21 January 2018

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Modulation of transcription factor Sp1 by cAMP-dependent protein kinase.

21 January 2018

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O glycosylation of an Sp1-derived peptide blocks known Sp1 protein interactions

21 January 2018

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Transcription factors of the Sp1 family: interaction with E2F and regulation of the murine thymidine kinase promoter

21 January 2018

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Induction of vascular endothelial growth factor by tumor necrosis factor alpha in human glioma cells. Possible roles of SP-1.

21 January 2018

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Expression of the vascular endothelial growth factor gene is inhibited by p73.

21 January 2018

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Involvement of the Sp1 site in ras-mediated downregulation of the RECK metastasis suppressor gene

21 January 2018

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Characterization of the lung Krüppel-like transcription factor gene and upstream regulatory elements

21 January 2018

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Identification of KLF13 and KLF14 (SP6), novel members of the SP/XKLF transcription factor family

21 January 2018

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Klf4 is a transcription factor required for establishing the barrier function of the skin

21 January 2018

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The retinoblastoma-susceptibility gene product binds directly to the human TATA-binding protein-associated factor TAFII250

21 January 2018

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Stimulation of human insulin receptor gene expression by retinoblastoma gene product

21 January 2018

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Isolation and characterization of a gene encoding human Kruppel-like factor 5 (IKLF): binding to the CAAT/GT box of the mouse lactoferrin gene promoter

21 January 2018

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Gut-enriched Krüppel-like factor represses cyclin D1 promoter activity through Sp1 motif

21 January 2018

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Identification of the DNA sequence that interacts with the gut-enriched Krüppel-like factor

21 January 2018

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Identification and characterization of a gene encoding a gut-enriched Krüppel-like factor expressed during growth arrest

21 January 2018

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Expression and regulatory function of the transcription factor Sp1 in the uterine endometrium at early pregnancy: implications for epithelial phenotype

21 January 2018

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RFLAT-1: a new zinc finger transcription factor that activates RANTES gene expression in T lymphocytes

21 January 2018

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Characterization and promoter analysis of the mouse gene for transcription factor Sp4.

21 January 2018

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Sp1 and NF-Y are necessary and sufficient for growth-dependent regulation of the hamster thymidine kinase promoter

21 January 2018

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Transcription factor erythroid Krüppel-like factor (EKLF) is essential for the erythropoietin-induced hemoglobin production but not for proliferation, viability, or morphological maturation

21 January 2018

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Expression of the SRF gene occurs through a Ras/Sp/SRF-mediated-mechanism in response to serum growth signals

21 January 2018

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Inhibition of vascular endothelial growth factor expression in HEC1A endometrial cancer cells through interactions of estrogen receptor alpha and Sp3 proteins

21 January 2018

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Identification of a novel TGF-beta-regulated gene encoding a putative zinc finger protein in human osteoblasts

21 January 2018

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Intestinal-enriched Krüppel-like factor (Krüppel-like factor 5) is a positive regulator of cellular proliferation

21 January 2018

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Sp4, a member of the Sp1-family of zinc finger transcription factors, is required for normal murine growth, viability, and male fertility.

21 January 2018

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Overexpression of the TGFbeta-regulated zinc finger encoding gene, TIEG, induces apoptosis in pancreatic epithelial cells

21 January 2018

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Target Detection Assay (TDA): a versatile procedure to determine DNA binding sites as demonstrated on SP1 protein

21 January 2018

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Expression of the gut-enriched Krüppel-like factor gene during development and intestinal tumorigenesis

21 January 2018

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Induction of Sp1 activity by prolactin and interleukin-2 in Nb2 T-cells: differential association of Sp1-DNA complexes with Stats

21 January 2018

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The tax protein of human T-cell leukemia virus type 1 mediates the transactivation of the c-sis/platelet-derived growth factor-B promoter through interactions with the zinc finger transcription factors Sp1 and NGFI-A/Egr-1.

21 January 2018

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Additive effect of Sp1 and Sp3 in regulation of the ED-L1E promoter of the EBV LMP 1 gene in human epithelial cells.

21 January 2018

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Cloning and characterization of mCtBP2, a co-repressor that associates with basic Krüppel-like factor and other mammalian transcriptional regulators

21 January 2018

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Basic Krüppel-like factor functions within a network of interacting haematopoietic transcription factors

21 January 2018

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Mammalian Krüppel-like transcription factors: more than just a pretty finger

21 January 2018

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Sp-1 binds promoter elements regulated by the RB protein and Sp-1-mediated transcription is stimulated by RB coexpression

21 January 2018

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Functional interactions between the retinoblastoma (Rb) protein and Sp-family members: superactivation by Rb requires amino acids necessary for growth suppression

21 January 2018

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The role of Sp family members, basic Kruppel-like factor, and E box factors in the basal and IFN-gamma regulated expression of the human complement C4 promoter

21 January 2018

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Gene structure, cDNA sequence, and expression of murine Bak, a proapoptotic Bcl-2 family member

21 January 2018

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Transcriptional activation of the porcine P450 11A insulin-like growth factor response element in MCF-7 breast cancer cells

21 January 2018

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The promyelocytic leukemia protein interacts with Sp1 and inhibits its transactivation of the epidermal growth factor receptor promoter

21 January 2018

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The Sequence of the Human Genome

21 January 2018

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A Sp1 binding site of the tumor necrosis factor alpha promoter functions as a nitric oxide response element

21 January 2018

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Isolation and molecular characterization of the 5'-upstream region of the human TRAIL gene

21 January 2018

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cDNA isolation, genomic structure, regulation, and chromosomal localization of human lung Kruppel-like factor

21 January 2018

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Lung Kruppel-like factor, a zinc finger transcription factor, is essential for normal lung development

21 January 2018

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BTEB2, a Krüppel-like transcription factor, regulates expression of the SMemb/Nonmuscle myosin heavy chain B (SMemb/NMHC-B) gene

21 January 2018

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Transcriptional regulation of neurofilament expression by protein kinase A.

21 January 2018

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The multifaceted roles of nitric oxide in cancer.

21 January 2018

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Antioxidant treatment induces transcription and expression of transforming growth factor beta in cultured renal proximal tubular cells

21 January 2018

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Human EZF, a Krüppel-like zinc finger protein, is expressed in vascular endothelial cells and contains transcriptional activation and repression domains

21 January 2018

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Genomic organization and chromosomal mapping of the bovine Fas/APO-1 gene.

21 January 2018

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Involvement of interleukin-8, vascular endothelial growth factor, and basic fibroblast growth factor in tumor necrosis factor alpha-dependent angiogenesis

21 January 2018

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Mechanism of initiator-mediated transcription: evidence for a functional interaction between the TATA-binding protein and DNA in the absence of a specific recognition sequence

21 January 2018

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Acetylation and modulation of erythroid Krüppel-like factor (EKLF) activity by interaction with histone acetyltransferases

21 January 2018

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The gut-enriched Krüppel-like factor suppresses the activity of the CYP1A1 promoter in an Sp1-dependent fashion

21 January 2018

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The gut-enriched Kruppel-like factor (Kruppel-like factor 4) mediates the transactivating effect of p53 on the p21WAF1/Cip1 promoter

21 January 2018

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Synergistic cooperation between Sp1 and Smad3/Smad4 mediates transforming growth factor beta1 stimulation of alpha 2(I)-collagen (COL1A2) transcription

21 January 2018

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Activation of apolipoprotein AI gene expression by protein kinase A and kinase C through transcription factor, Sp1.

21 January 2018

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Identification of a mouse homolog of the human BTEB2 transcription factor as a beta-catenin-independent Wnt-1-responsive gene

21 January 2018

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Transcriptional Regulation of the p21(WAF1/CIP1)Gene

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/JCP.1111

1 reference

30 July 2017

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